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I had serious kidney problems after 18 months on Avastin. Because it was so successful against my cancer, I think we stretched the rules somewhat -- if the protein in my urine was too high when I arrived at the onc's office, I'd hydrate for a while and then measure it again. By the time I stopped, I was really not in great shape -- primarily tremendous fatigue and edema. I was also on Abraxane, which was tough in its own way. It took me about 6 months to start feeling good again, and I've been warned by a nephrologist against going back on Avastin.
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