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09-13-2010, 12:45 PM
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#1
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Member
Join Date: Nov 2009
Location: UK
Posts: 24
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Liver Function Test
Dear friends
Please help me. Haven't been having any treatment for 8 weeks - waiting for Lapatinib to be allowed for me. Didn't get it, got Femara on its own. Started 10 days ago.
All that time my CA been stadily rising.And now my blood test, which was fine, show change in LFT. ALT and Alkaline Prosphotase increased greatly ( Bilirubin, etc. are normal).I know Alk. Pros. may be connected to my bones problem - don't care much. It's ALT that worries me. Is it definite sign of cancer progression or may be an other reason? I tried Google without much success.
I appriciate any response.You amazing fighters always give me strength and hope.
Be blessed
Galina
__________________
Dx 11/06 age 60
2.8cm Grade 2
ER+++/PR+/HER2+++
R. mast., 5 FEC, 6 Taxotere, 35 radiation
11 mth Herceptin
while on Arimidex 11/09 recurrence to bones (widespread), liver
5 rad. on spine, 6 Taxotere, Herceptin, Zometa
while on this, progression
Xeloda, Zometa every 3 weeks
07/10 stopped Xeloda - doesn't work
having just Zometa, waiting for another treatment
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09-13-2010, 12:55 PM
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#2
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Senior Member
Join Date: Jan 2008
Location: "Love never fails."
Posts: 5,809
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Re: Liver Function Test
Galina,
This link from National Library of Medicine explains what ALT is:
http://www.nlm.nih.gov/medlineplus/e...cle/003473.htm
Looks like they are just checking on your liver function.
__________________
Jackie07
http://www.kevinmd.com/blog/2011/06/doctors-letter-patient-newly-diagnosed-cancer.html
http://www.asco.org/ASCOv2/MultiMedi...=114&trackID=2
NICU 4.4 LB
Erythema Nodosum 85
Life-long Central Neurocytoma 4x5x6.5 cm 23 hrs 62090 semi-coma 10 d PT OT ST 30 d
3 Infertility tmts 99 > 3 u. fibroids > Pills
CN 3 GKRS 52301
IDC 1.2 cm Her2 +++ ER 5% R. Lmptmy SLNB+1 71703 6 FEC 33 R Tamoxifen
Recc IIB 2.5 cm Bi-L Mast 61407 2/9 nds PET
6 TCH Cellulitis - Lymphedema - compression sleeve & glove
H w x 4 MUGA 51 D, J 49 M
Diastasis recti
Tamoxifen B. scan
Irrtbl bowel 1'09
Colonoscopy 313
BRCA1 V1247I
hptc hemangioma
Vertigo
GI - > yogurt
hysterectomy/oophorectomy 011410
Exemestane 25 mg tab 102912 ~ 101016 stopped due to r. hip/l.thigh pain after long walk
DEXA 1/13
1-2016 lesions in liver largest 9mm & 1.3 cm onco. says not cancer.
3-11 Appendectomy - visually O.K., a lot of puss. Final path result - not cancer.
Start Vitamin D3 and Calcium supplement （600mg x2)
10-10 Stopped Exemestane due to r. hip/l.thigh pain OKed by Onco 11-08-2016
7-23-2018 9 mm groundglass nodule within the right lower lobe with indolent behavior. Due to possible adenocarcinoma, Recommend annual surveilence.
7-10-2019 CT to check lung nodule.
1-10-2020 8mm stable nodule on R Lung, two 6mm new ones on L Lung, a possible lymph node involvement in inter fissule.
"I WANT TO BE AN OUTRAGEOUS OLD WOMAN WHO NEVER GETS CALLED AN OLD LADY. I WANT TO GET SHARP EDGED & EARTH COLORED, TILL I FADE AWAY FROM PURE JOY." Irene from Tampa
Advocacy is a passion .. not a pastime - Joe
Last edited by Jackie07; 09-13-2010 at 01:13 PM..
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09-14-2010, 12:57 AM
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#3
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Senior Member
Join Date: May 2010
Location: Melbourne, Australia
Posts: 434
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Re: Liver Function Test
It is really hard to know. Some liver function tests reflect changes as a result of chemo. I don't know if ALT is one or if Femara can be responsible for the change. Tests aside I hope you are feeling well. Wishing you the best.
Trish
__________________
5/2004 (R) 30mm bre gr3 infiltrating ductal ca 16/18nodes er (2+) pr (3+) HER2 (3+)
6/2004 6 cycles(FEC), Oct 40 rads, Tamoxifen
5/2006 oopherectomy, Arimedex
12/2006 liver mets largest 9cm
1/2007 Herceptin,
3/2007 Taxol + Herc
1/2008 Herc alone
4/2008 Multiple bone mets,Zometa
7/2008 Herc + Gemcitabine
8/2008 Herc+Navelbine/vinoralbine
10/2008 Herc+Carboplatin+Taxol
12/2008 Tykerb+Xeloda
2/2010 Herceptin + trial drug
5/2010 Herceptin+Tykerb
8/2010 Tykerb+Abraxane
9/2010 Abraxane
12/2010 Abraxane+Tyk+Herc
4/2011 Tyk+Herc+Femara
6/2011 Liver and bone mets prog.Abraxane continue Herceptin,Tykerb,Femara and Zometa
8/2011 Probable liver progression and increased neuropathy. Xeloda with Tyk+Herc. Zometa 6 weekly.
9/2011 Liver progression,TM +++. Cyclophosphamide and Methotrexate metro Herc Zometa
10/2011 liver mets prog.Herc, 3 Tykerb +2mg decodron daily,Zometa
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09-14-2010, 12:40 PM
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#4
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Member
Join Date: Nov 2009
Location: UK
Posts: 24
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Re: Liver Function Test
Jackie and Trish, thank you for your kind replies. I know it doesn't look good, but yes Trish I feel well, just terrified.
Next week CT scan will have the answer.
Thank you again for your support.
With love
Galina
__________________
Dx 11/06 age 60
2.8cm Grade 2
ER+++/PR+/HER2+++
R. mast., 5 FEC, 6 Taxotere, 35 radiation
11 mth Herceptin
while on Arimidex 11/09 recurrence to bones (widespread), liver
5 rad. on spine, 6 Taxotere, Herceptin, Zometa
while on this, progression
Xeloda, Zometa every 3 weeks
07/10 stopped Xeloda - doesn't work
having just Zometa, waiting for another treatment
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09-16-2010, 02:05 PM
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#5
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Member
Join Date: Nov 2009
Location: UK
Posts: 24
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Re: Liver Function Test
Hi all
Just let you know, the cause of elevated LFT had apparently not much to do with ca. I've been experimenting with some supplements while waiting for treatment. One of them I suspected could affect those figures and when I stoped taking it four days ago they just dropped.
Don't know what CT will show it's still sort of relief for now, thank God.
With love
Galina
__________________
Dx 11/06 age 60
2.8cm Grade 2
ER+++/PR+/HER2+++
R. mast., 5 FEC, 6 Taxotere, 35 radiation
11 mth Herceptin
while on Arimidex 11/09 recurrence to bones (widespread), liver
5 rad. on spine, 6 Taxotere, Herceptin, Zometa
while on this, progression
Xeloda, Zometa every 3 weeks
07/10 stopped Xeloda - doesn't work
having just Zometa, waiting for another treatment
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09-18-2010, 11:02 PM
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#6
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Senior Member
Join Date: May 2010
Location: Melbourne, Australia
Posts: 434
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Re: Liver Function Test
That is fantastic news. Thanks for letting us know. I have been wondering how you are getting on.
Trish
__________________
5/2004 (R) 30mm bre gr3 infiltrating ductal ca 16/18nodes er (2+) pr (3+) HER2 (3+)
6/2004 6 cycles(FEC), Oct 40 rads, Tamoxifen
5/2006 oopherectomy, Arimedex
12/2006 liver mets largest 9cm
1/2007 Herceptin,
3/2007 Taxol + Herc
1/2008 Herc alone
4/2008 Multiple bone mets,Zometa
7/2008 Herc + Gemcitabine
8/2008 Herc+Navelbine/vinoralbine
10/2008 Herc+Carboplatin+Taxol
12/2008 Tykerb+Xeloda
2/2010 Herceptin + trial drug
5/2010 Herceptin+Tykerb
8/2010 Tykerb+Abraxane
9/2010 Abraxane
12/2010 Abraxane+Tyk+Herc
4/2011 Tyk+Herc+Femara
6/2011 Liver and bone mets prog.Abraxane continue Herceptin,Tykerb,Femara and Zometa
8/2011 Probable liver progression and increased neuropathy. Xeloda with Tyk+Herc. Zometa 6 weekly.
9/2011 Liver progression,TM +++. Cyclophosphamide and Methotrexate metro Herc Zometa
10/2011 liver mets prog.Herc, 3 Tykerb +2mg decodron daily,Zometa
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09-18-2010, 11:29 PM
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#7
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Senior Member
Join Date: Feb 2008
Location: South East Wisconsin
Posts: 3,431
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Re: Liver Function Test
What supplement(s)?
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09-19-2010, 02:09 PM
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#8
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Member
Join Date: Nov 2009
Location: UK
Posts: 24
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Re: Liver Function Test
The supplement is Rhodiola Rosea. It was really good from the start. With the help of RR I
1. was able to drop antidepressants I been taking for 9 mns.
2.my arthritis I been having for ages and which become very bad from all my treatment - just gone.
3.generally I felt really well, like never before.
It was said RR help in case of liver cancer.I took a risk as I hate to do nothing when something should be done as I haven't been having any treatment for weeks.
The fact that RR affected my LFT (and probably made ca in my liver worse - CT will show) I think is down to hormons. My ca is ER+++, and there is strong connection between RR and hormons as said it improves sex life( last thing I would think of in my situation).
It just shows we have to be very careful using those good supplements as they might give unwanted side effects depending on individual case.
Thank you for your kind replies.
With love
Galina
__________________
Dx 11/06 age 60
2.8cm Grade 2
ER+++/PR+/HER2+++
R. mast., 5 FEC, 6 Taxotere, 35 radiation
11 mth Herceptin
while on Arimidex 11/09 recurrence to bones (widespread), liver
5 rad. on spine, 6 Taxotere, Herceptin, Zometa
while on this, progression
Xeloda, Zometa every 3 weeks
07/10 stopped Xeloda - doesn't work
having just Zometa, waiting for another treatment
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09-24-2010, 02:35 PM
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#9
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Member
Join Date: Nov 2009
Location: UK
Posts: 24
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Re: Liver Function Test
Just to say I probably was wrong blaming RR, as blood test today shows ALT still increasing.
I'm taking Femara as well and so many factors might possibly affect those results that difficult to say which one is real cause.
With love
g.
__________________
Dx 11/06 age 60
2.8cm Grade 2
ER+++/PR+/HER2+++
R. mast., 5 FEC, 6 Taxotere, 35 radiation
11 mth Herceptin
while on Arimidex 11/09 recurrence to bones (widespread), liver
5 rad. on spine, 6 Taxotere, Herceptin, Zometa
while on this, progression
Xeloda, Zometa every 3 weeks
07/10 stopped Xeloda - doesn't work
having just Zometa, waiting for another treatment
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09-24-2010, 03:48 PM
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#10
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Senior Member
Join Date: Jan 2008
Location: "Love never fails."
Posts: 5,809
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Re: Liver Function Test
Have you told your doctor about RR?
__________________
Jackie07
http://www.kevinmd.com/blog/2011/06/doctors-letter-patient-newly-diagnosed-cancer.html
http://www.asco.org/ASCOv2/MultiMedi...=114&trackID=2
NICU 4.4 LB
Erythema Nodosum 85
Life-long Central Neurocytoma 4x5x6.5 cm 23 hrs 62090 semi-coma 10 d PT OT ST 30 d
3 Infertility tmts 99 > 3 u. fibroids > Pills
CN 3 GKRS 52301
IDC 1.2 cm Her2 +++ ER 5% R. Lmptmy SLNB+1 71703 6 FEC 33 R Tamoxifen
Recc IIB 2.5 cm Bi-L Mast 61407 2/9 nds PET
6 TCH Cellulitis - Lymphedema - compression sleeve & glove
H w x 4 MUGA 51 D, J 49 M
Diastasis recti
Tamoxifen B. scan
Irrtbl bowel 1'09
Colonoscopy 313
BRCA1 V1247I
hptc hemangioma
Vertigo
GI - > yogurt
hysterectomy/oophorectomy 011410
Exemestane 25 mg tab 102912 ~ 101016 stopped due to r. hip/l.thigh pain after long walk
DEXA 1/13
1-2016 lesions in liver largest 9mm & 1.3 cm onco. says not cancer.
3-11 Appendectomy - visually O.K., a lot of puss. Final path result - not cancer.
Start Vitamin D3 and Calcium supplement （600mg x2)
10-10 Stopped Exemestane due to r. hip/l.thigh pain OKed by Onco 11-08-2016
7-23-2018 9 mm groundglass nodule within the right lower lobe with indolent behavior. Due to possible adenocarcinoma, Recommend annual surveilence.
7-10-2019 CT to check lung nodule.
1-10-2020 8mm stable nodule on R Lung, two 6mm new ones on L Lung, a possible lymph node involvement in inter fissule.
"I WANT TO BE AN OUTRAGEOUS OLD WOMAN WHO NEVER GETS CALLED AN OLD LADY. I WANT TO GET SHARP EDGED & EARTH COLORED, TILL I FADE AWAY FROM PURE JOY." Irene from Tampa
Advocacy is a passion .. not a pastime - Joe
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09-26-2010, 12:52 PM
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#11
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Member
Join Date: Nov 2009
Location: UK
Posts: 24
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Re: Liver Function Test
I had no chance yet, but from my past experience he wasn't interested in supplements I'm taking and haven't heard of RR when I tried to ask him before.
__________________
Dx 11/06 age 60
2.8cm Grade 2
ER+++/PR+/HER2+++
R. mast., 5 FEC, 6 Taxotere, 35 radiation
11 mth Herceptin
while on Arimidex 11/09 recurrence to bones (widespread), liver
5 rad. on spine, 6 Taxotere, Herceptin, Zometa
while on this, progression
Xeloda, Zometa every 3 weeks
07/10 stopped Xeloda - doesn't work
having just Zometa, waiting for another treatment
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03-16-2011, 06:20 PM
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#12
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Senior Member
Join Date: Jan 2008
Location: "Love never fails."
Posts: 5,809
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Re: Liver Function Test
Vera,
Haven't heard from you since October. Wondered how you are doing. Have you tried other combination after Zometa?
__________________
Jackie07
http://www.kevinmd.com/blog/2011/06/doctors-letter-patient-newly-diagnosed-cancer.html
http://www.asco.org/ASCOv2/MultiMedi...=114&trackID=2
NICU 4.4 LB
Erythema Nodosum 85
Life-long Central Neurocytoma 4x5x6.5 cm 23 hrs 62090 semi-coma 10 d PT OT ST 30 d
3 Infertility tmts 99 > 3 u. fibroids > Pills
CN 3 GKRS 52301
IDC 1.2 cm Her2 +++ ER 5% R. Lmptmy SLNB+1 71703 6 FEC 33 R Tamoxifen
Recc IIB 2.5 cm Bi-L Mast 61407 2/9 nds PET
6 TCH Cellulitis - Lymphedema - compression sleeve & glove
H w x 4 MUGA 51 D, J 49 M
Diastasis recti
Tamoxifen B. scan
Irrtbl bowel 1'09
Colonoscopy 313
BRCA1 V1247I
hptc hemangioma
Vertigo
GI - > yogurt
hysterectomy/oophorectomy 011410
Exemestane 25 mg tab 102912 ~ 101016 stopped due to r. hip/l.thigh pain after long walk
DEXA 1/13
1-2016 lesions in liver largest 9mm & 1.3 cm onco. says not cancer.
3-11 Appendectomy - visually O.K., a lot of puss. Final path result - not cancer.
Start Vitamin D3 and Calcium supplement （600mg x2)
10-10 Stopped Exemestane due to r. hip/l.thigh pain OKed by Onco 11-08-2016
7-23-2018 9 mm groundglass nodule within the right lower lobe with indolent behavior. Due to possible adenocarcinoma, Recommend annual surveilence.
7-10-2019 CT to check lung nodule.
1-10-2020 8mm stable nodule on R Lung, two 6mm new ones on L Lung, a possible lymph node involvement in inter fissule.
"I WANT TO BE AN OUTRAGEOUS OLD WOMAN WHO NEVER GETS CALLED AN OLD LADY. I WANT TO GET SHARP EDGED & EARTH COLORED, TILL I FADE AWAY FROM PURE JOY." Irene from Tampa
Advocacy is a passion .. not a pastime - Joe
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