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05-22-2010, 06:51 PM
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#1
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Senior Member
Join Date: Oct 2009
Posts: 98
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Infusion times?
Went for my herceptin "cocktail" yesterday. They said a bunch of words I don't remember (I was looking forward to a nap)...but something about some study ?...the docs all reviewed it and agreed that 30 minute infusion times versus 1.5 hours is appropriate.
Anyone else hear, experience this that can explain?
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05-22-2010, 07:07 PM
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#2
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Senior Member
Join Date: Apr 2009
Location: La Quinta, Ca
Posts: 253
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Re: Infusion times?
All of the infusion centers I use infuse a three week dose of Herceptin over 30 minutes. For the longest time I insisted on having it over 1.5 hrs----part of my reasoning was superstition I guess. But I asked Dr. Slamon's office and was told only the first infusion needs to be over 1.5 hrs. From then on 30 minutes is fine. In reality, it always takes them longer than 30 minutes.
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05-22-2010, 08:47 PM
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#3
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Senior Member
Join Date: Jan 2007
Location: Thornhill, Ontario
Canada
Posts: 2,320
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Re: Infusion times?
Patricia, after the initial loading dose, when I went for the regular every 3 week infusion, they started me at 30 minutes. However, after the first one, I felt a bit "shaky" afterwards, and due to the advice of members of this website, I was advised to ask for a 60 minute infusion. I did ask for a 60 minute infusion, and all the remaining ones were fine.
all the best
caya
__________________
ER90%+/PR 50%+/HER 2+
1.7 cm and 1.0 cm.
Stage 1, grade 2, Node Negative (16 nodes tested)
MRM Dec.18/06
3 x FEC, 3 x Taxotere
Herceptin - every 3 weeks for a year, finished May 8/08
Tamoxifen - 2 1/2 years
Femara - Jan. 1, 2010 - July 18, 2012
BRCA1/BRCA2 Negative
Dignosed 10/16/06, age 48 , premenopausal
Mild lymphedema diagnosed June 2009 - breast surgeon and lymph. therapist think it's completely reversible - hope so.
Reclast infusion January 2012
Oopherectomy October 2013
15 Years NED!!
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05-23-2010, 06:10 AM
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#4
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Senior Member
Join Date: Oct 2005
Posts: 823
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Re: Infusion times?
My first infusion was done in 90 minutes and then I went to weekly and they did them in 30 minutes, I asked to have it done slower and then went to an hour and I did feel much better after that, I also had them run saline after the infusion was done. I seemed to have less problems when it was done over an hour.
__________________
Vicki
Texas
Biopsy Dx'd 3-23-05 Age 48
MRM 4-5-05 w/ 2 tumor's 5cm, and 6 cm (right side)
IDC (poorly differentiated infiltrating ductual carcinoma)
5+/16 nodes
Stage III A
Grade 3
ER/PR-, Her2/neu ++
Ki67 78%
Begin Chemo 5-2-05 4XAC Dose Dense , 4X Abraxane Dose Dense (ended August 05)
28 Rad's ended October 13 2005
Started Herceptin Weekly August 2005 for one year
Had a Simple mastectomy left side after Mamo showed incresed micro-calcifications. Jan. 17 2006.
Brain MRI Feb.2006--All Clear
August 28, 2006 Last Weekly Herceptin.
October 2006--Colonoscopy, 6 Polyp's removed--all B9
PET Scan July 2007
Abdominal MRI Oct. 2007---2 Right Kidney Cysts
Core Biopsy-- Lump on Scar Line 1-10-08---B9
Brain MRI 6-2008--All Clear
PET/CT Scan 6-2008
Sept. 8 2008, 4CM area removed from mastectomy scar line. Proved to be B9.
PET/CT Scan-- July 2009 --All clear
August 17,2009 ---Had Port Removed
6 Years NED -- April 5,2011
DX'd with Melanoma left arm 10-10-2011
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05-23-2010, 06:53 AM
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#5
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Senior Member
Join Date: Feb 2009
Posts: 1,526
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Re: Infusion times?
Hi
Here in England it's usually given over half an hour. I try to have mine slower (45-60 MINS) as i found I had less joint pains afterwards. I mentioned this to my onc and he was fine about it. His reasoning was that it took longer to metabolise if given slower which might explain less side effects.
Ellie
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05-23-2010, 01:28 PM
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#6
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Senior Member
Join Date: Oct 2009
Posts: 98
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Re: Infusion times?
Hmmm...I'm almost done and this is the first they've said anything about lesser times. Maybe my facility is not so cutting edge, but tried and true, which might not be a bad thing?
thanks everyone.
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05-23-2010, 01:41 PM
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#7
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Senior Member
Join Date: Sep 2005
Location: Newton, MA
Posts: 951
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Re: Infusion times?
I have always had it for 30 minutes. The loading dose was longer. I have not had side effects with Herceptin.
Barbara H.
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05-23-2010, 03:01 PM
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#8
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Senior Member
Join Date: Nov 2005
Location: Ireland
Posts: 3,463
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Re: Infusion times?
I always had the longer dose Patricia, but just as i finished my year the nurse told me they were bringing in the thirty minute infusion but did'nt have it myself.
__________________
Tricia
Dx July '05 IDC 1.9cm Triple positive 3/9 nodes positive
A/C X 4 ..Taxol/Herceptin x 12 wks then herceptin 1 yr
Rads x 36 ..oophorectomy August '06
Currently taking Arimidex..
June 2011 osteopenia/ zometa x1 yearly- stopped Zometa 2015 as Dexa show normal bone density.
Stopped Arimidex July 2014- Restarted Arimidex 2015 for a further two years on the advice of my Onc.
2014 Normal Dexa scan
2018 Mammo all clear, still NED!
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05-23-2010, 05:04 PM
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#9
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Senior Member
Join Date: Feb 2010
Location: TN
Posts: 175
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Re: Infusion times?
Similar to the experience of the other commenters, I get my weekly infusion of Herceptin over a 30 minute interval. That rate works well for me with no ill effects afterward. I get 173 mg of H. each time. In fact, I go in the morning for number 44. Eight to go.
bird
__________________
Male Breast Cancer, DX 5/15/09, IDC, STAGE 1, 1.7 cm, HER2+++, ER+(95%)/PR+(75%), Ki67 40%, grade 3, 0/5 nodes, TX: mastectomy, TCH finished 7/19/10, radiation 6 wks., Tamoxifen on going, bisphosphonate 24 mos.
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05-24-2010, 06:00 PM
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#10
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Senior Member
Join Date: Oct 2007
Posts: 1,851
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Re: Infusion times?
Patrice,
My Herceptin infusion is 30 minutes.
Joan
__________________
Diagnosed stage 2b in July 2003 (2.3 cm, HER2+, ER-/PR-, 7+ nodes). Treated with mastectomy (with immediate DIEP flap reconstruction), AC + T/Herceptin (off label). Cancer advanced to lung in Jan. 2007 (1 cm nodule). Started Herceptin every 3 weeks. Lung wedge resection April 2007. Cancer recurred in lung April 2008. RFA of lung in August 2008. 2nd annual brain MRI in Oct. 2008 discovered 2.6 cm cystic tumor in left frontal lobe. Craniotomy Oct. 2008 (ER-/PR-/HER2-) followed by targeted radiation (IMRT). Coughing up blood Feb. 2009. Thoractomy July 2009 to cut out fungal ball of common soil fungus (aspergillus) that grew in the RFA cavity (most likely inhaled while gardening). No cancer, only fungus. Removal of tiny melanoma from upper left arm, plus sentinel lymph node biopsy in Feb. 2016. Guardant Health liquid biopsy in Feb. 2016 showed mutations in 4 subtypes of TP53. Repeat of Guardant Health biopsy in Jana. 2021 showed 3 TP53 mutations, BRCA1 mutation and CHEK2 mutation. Invitae genetic testing showed negative for all of these. Living with MBC since 2007. Stopped Herceptin Hylecta (injection) treatment in March 2020. Recent 2023 annual CT of chest, abdomen and pelvis and annual brain MRI showed NED. Praying for NED forever!!
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