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Old 11-17-2009, 05:39 PM   #1
Mariam
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Join Date: Nov 2009
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Herceptin without Chemo???

Hello,
I feel that I'm losing my mind. There have been differing opinions regarding my treatment with Herceptin. I wondered if anyone has experience or thoughts to help.

I'm 44, at 32 I had breast cancer (infiltrating ductal carcinoma)one lymph node positive- lumpectomy, chemo, and radiation. ER positive negated 5 years of Tamoxifen, 5 years Lupron/Zoladez injections with Arimidex pills.

Recurrence seen by mammogram this August. I had a masectomy. The tumor size is small .6mm but now HER 2 positive. Two cancers now infiltrating and insitu ductal carcinoma (They did not have HER2 testing previously) Oncologist wants to treat with hormone and Herceptin without chemo. HAS ANYONE had Herceptin treatment without chemo? Another oncologist indicated that it wasn't as effective. PLEASE HELP.
Mariam
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Old 11-17-2009, 07:55 PM   #2
BonnieR
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Re: Herceptin without Chemo???

It has been done. That was an option I was offered at one point. But in researching further it seemed a big grey area and we chose to do the full deal. All the experts I spoke with recommended the chemo in conjunction with Herceptin. What is your doctor's reasoning?
ETA: Keep the faith
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Bonnie

Post menopause
May 2007 Core biopsy, Rt breast
ER+, Pr-, HER2 +++, Grade 3
Ki-67: 90%
"suspicious area" left breast
Bilateral mastectomy, (NED on left) May 2007
Sentinel Node Neg
Stage 1, DCIS with microinvasion, 3 mm, mostly removed during the biopsy....
Femara (discontinued 7/07) Resumed 10/07
OncoType score 36 (July 07)
Began THC 7/26/07 (d/c taxol and carboplatin 10/07)
Began Herceptin alone 10/07
Finished Herceptin July /08
D/C Femara 4/10 (joint pain/trigger thumb!)
5/10 mistakenly dx with lung cancer. Middle rt lobe removed!
Aromasin started 5/10
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Old 11-17-2009, 08:28 PM   #3
Barbara H.
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Location: Newton, MA
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Re: Herceptin without Chemo???

I would get a second opinion. There are many possible combinations. Sometimes patients just receive Herceptin with Taxol.
Best wishes,
Barbara H.
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Old 11-17-2009, 08:33 PM   #4
Chelee
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Location: Southern, CA
Posts: 2,511
Re: Herceptin without Chemo???

I'm with Barbara on this one...get another opinion. I just had a recurrence and the two 2nd opinions I had wanted to add Navelbine or Taxotere to the Herceptin.

I highly suggest you take the time to go see one more onc...and one that specializes in breast cancer and is up on Her2 cancer. Your doing a great job already by checking it out here. Hang in there and keep us updated on what you find out.

Chelee
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DX: 12-20-05 - Stage IIIA, Her2/Neu, 3+++,Er & Pr weakly positive, 5 of 16 pos nodes.
Rt. MRM on 1-3-06 -- No Rads due to compromised lungs.
Chemo started 2-7-06 -- TCH - - Finished 6-12-06
Finished yr of wkly herceptin 3-19-07
3-15-07 Lt side prophylactic simple mastectomy. -- Ooph 4-05-07
9-21-09 PET/CT "Recurrence" to Rt. axllia, Rt. femur, ilium. Possible Sacrum & liver? Now stage IV.
9-28-09 Loading dose of Herceptin & started Zometa
9-29-09 Power Port Placement
10-24-09 Mass 6.4 x 4.7 cm on Rt. femur head.
11-19-09 RT. Femur surgery - Rod placed
12-7-09 Navelbine added to Herceptin/Zometa.
3-23-10 Ten days of rads to RT femur. Completed.
4-05-10 Quit Navelbine--Herceptin/Zometa alone.
5-4-10 Appt. with Dr. Slamon to see what is next? Waiting on FISH results from femur biopsy.
Results to FISH was unsuccessful--this happens less then 2% of the time.
7-7-10 Recurrence to RT axilla again. Back to UCLA for options.
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