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05-24-2008, 05:00 PM
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#1
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Senior Member
Join Date: Jul 2005
Location: Ft. Collins, Colorado
Posts: 546
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to worry or not to worry
Hi guys, it is me, the nuthead. I saw the onc on thursday and my last CMP showed an elevation in alk phos and a slight elevation in AST or ALT now can't remember which, the other is normal as is everything else. I was pretty upset about it as they have been all normal for so long. Would any of you know if these could be affected by oophorectomy, faslodex, hormonal flare, herceptin, and or zometa? My hopeful self wants to think that some of the elevation has to do with the hormonal flare as I did have some pain in bone spots shortly after beginning this treatment. Can't seem to find a lot out there about that though. I really hope it is not progression related. And I know that faslodex can take 8 weeks to work, we just don't want to lose any windows of time in case I can do DM-1.
I could really use your brains as I know you are all so wise. Thank you and happy long weekend!
__________________
with love and gratitude,
joy
dx stage I 2/2000*er/pr+; her- per IHC*lumpectomy*4 rounds A/C*30 rads*tamoxifen*dx stage 4 5/2002*huge mets to liver*tiny mets to lungs*stopped tamoxifen*5/02 taxotere/xeloda*her 2 checked with FiSH-her2+++herceptin *2/03 stopped chemo femara w/herceptin*zolodex*04 switched to aromasin w/herceptin*05 high estrogen tx*11/05taxol/carbo*7/06 stopped chemo; megace/herceptin*9/06navelbine/herceptin*5/07tykerb/xeloda great response*4/08 progression in liver; ooph/ faslodex /herceptin
6/08 began Herceptin DM-1
9/08 progression
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05-24-2008, 09:59 PM
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#2
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Senior Member
Join Date: Nov 2007
Location: Connecticut
Posts: 2,077
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Hey Little Sis! I'm sorry I can't help with your question, but I know someone here can. Try not to worry too much, honey, alot of meds. can cause fluctuations in the liver enzymes. Love ya, Brother Bill
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05-24-2008, 10:15 PM
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#3
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Senior Member
Join Date: Jun 2007
Posts: 2,210
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I can't answer your question. But don't call yourself a "nuthead" because you are worrying. It is what we do best sometimes. Especially over long weekends.
I am sure someone here will be able to offer some insights for you.
Keep the faith.
__________________
Bonnie
Post menopause
May 2007 Core biopsy, Rt breast
ER+, Pr-, HER2 +++, Grade 3
Ki-67: 90%
"suspicious area" left breast
Bilateral mastectomy, (NED on left) May 2007
Sentinel Node Neg
Stage 1, DCIS with microinvasion, 3 mm, mostly removed during the biopsy....
Femara (discontinued 7/07) Resumed 10/07
OncoType score 36 (July 07)
Began THC 7/26/07 (d/c taxol and carboplatin 10/07)
Began Herceptin alone 10/07
Finished Herceptin July /08
D/C Femara 4/10 (joint pain/trigger thumb!)
5/10 mistakenly dx with lung cancer. Middle rt lobe removed!
Aromasin started 5/10
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05-25-2008, 06:53 AM
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#4
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Senior Member
Join Date: Jul 2007
Location: BridgeView IL
Posts: 116
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Hi Joy,
My Internist explained to me that when the Alk Phos is elevated it is due to bone problems-in my case it seems to be degenerative arthritis in my knees. Mine has remained high for 4 months now. He ordered a GGTP-blood test to futher check the liver. I hope this helps a little. Take Care.
Tamara
Invasive Ductal Carcinoma 10/2006 HER2+
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05-25-2008, 11:49 AM
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#5
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Senior Member
Join Date: Sep 2005
Location: Mountains of Virginia
Posts: 2,267
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Joy,
I'm not a propeller head, but since zometa affects the bones, it may have something to do with it.
Hope you can enjoy the weekend.
__________________
Rhonda (Sassy)
dx age 45
DX 2/15/05 Stage IIb (at surgery)restaged IIIa
Left mast .9cm tumor 5 of 14 nodes
Triple Positive
4 DD A/C
12 Taxol/Herceptin
33Rads
Strange infect mast site one year aft surg, hosp 1 wk
Herceptin for total of 18 months
Lupron Monthly 4 yrs
Neurontin for aches, pains and hot flashes(It works!)
Ovaries removed 11/09 stop Lupron and Neurontin
Arimidex 6 yrs (tried Femara, no SE improvement)
Tried Exemestane-hips got so bad could hardly walk
Back to Arimidex for year seven
Zometa 2X Annual for 7years, Lasix
Stop Arimidex 5/13
Stop Zometa 7/13-Bi-lateral Stress Fractures in Femurs from Zometa
5/14 Start Tamoxifen
3/15 Stem cell transplant to stimulate femur bone growth/healing
5/15 Complete fracture of right femur/Titanium rods both femurs
9/16 Start Evista stopTamoxifen
3/17 Stop Evista--unwelcome side effects!
NED and no meds.......
14 YEARS NED!
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05-25-2008, 03:43 PM
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#6
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Senior Member
Join Date: Sep 2005
Location: Central Coast, CA
Posts: 3,207
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Joy,
Lots of things can cause these to fluctuate, and if bone stuff causes the Alk Phos to elevate, I'd say you may have found the culprit. You didn't say how high, or what your doctor had to say about it. I find that lots of times I freak and the doctor just laughs. I never want to see any * on my bloodwork! So, since this is easy to say, I'll say it: Don't freak unless your doctor tells you to!
By the way, should you get into a T-DM1 trial, be forewarned that it does cause elevation of these
__________________
Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial
5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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05-25-2008, 07:44 PM
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#7
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Senior Member
Join Date: Jun 2006
Location: Bradenton,FL
Posts: 977
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Chrisy...I have to comment on your "I never want to see any * on my bloodwork".... I think we should get T-shirts made up to that effect ! Its so true! I just got my results back last week from my 6 mo check up and I immediately looked for those "*"!
JOY , you are anything BUT a nutcase, hope you figure this out with your Oncs help!
Marcia
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05-25-2008, 09:07 PM
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#8
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Senior Member
Join Date: Mar 2007
Location: Hilo, Hawaii
Posts: 1,867
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Joy, my bilirubin total and sometimes my bilirubin direct, had fluctuations for about a yr after my chemo. It would go just a bit above the range of normal. For example if the range was 0-0.9, mine would be 1.3. I would look at the bottoms of my hands and feet and would swear it looked a bit too yellow. Maybe it was in my head and normal since I am Asian. My oncologist was not a bit alarmed and sure enough, I finally got within the normal range after a while.
I don't know if this info helped, but take it for what its worth.
__________________
*** MARYANNE *** aka HARRIECANARIE
1993: right side DCIS, lumpectomy, rads
1999: left side DCIS, lumpectomy, rads, tamoxifen
2006:
BRCA 2 positive
Stage I, invasive DCIS (6mm x 5mm)
Grade: intermediate
sentinal node biopsy: neg
HER2/neu amplified 4.7
ER+/PR+
TOPO II neg
Oncotype dx 20
Bilat mastectomy with DIEP flap reconstruction
oophorectomy
2007:
6 cycles TCH (taxotere, carboplatin, herceptin)
finished 1 yr herceptin 05/07
Arimidex, stopped after almost 1 yr
Femara
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