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05-22-2008, 08:59 AM
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#1
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Senior Member
Join Date: Oct 2005
Location: New Jersey
Posts: 3,154
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Stress Can Be Usefull (never thought I would say that)
Sharing a thought:
Stress can help us, sounds strange but consider the following, cavemen depended upon their physcial reaction to stress in order to survive. When confronted with anything that posed a threat the body's reaction to stress allowed the cavemen to be alert, focused and ready to "fight"...(is this sounding familiar to anyone)?
It is this survival response to stess that we still feel today when forced to deal with stress. Stress can be usefull (never thought I would say that).
Consider this: In nature, the continual wind on a tree can cause it to become very strong. This ever present stress forces the tree to stay grounded and dig deep to remain firmly planted in the ground.
Wanted to share this thought to all - especially to those memebers who are feeling high levels of stress. Our members are certainly strong fighters.
Love to all,
Jean
__________________
Stage 1, Grade 1, 3/30/05
Lumpectomy 4/15/05 - 6MM IDC
Node Neg. (Sentinel node)
ER+ 90% / PR-, Her2+++ by FISH
Ki-67 40%
Arimidex 5/05
Radiation 32 trt, 5/30/05
Oncotype DX test 4/17/06, 31% high risk
TOPO 11 neg. 4/06
Stopped Arimidex 5/06
TCH 5/06, 6 treatments
Herceptin 5/06 - for 1 yr.
9/06 Completed chemo
Started Femara Sept. 2006
Last edited by Jean; 05-22-2008 at 09:29 AM..
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05-22-2008, 12:18 PM
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#2
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Senior Member
Join Date: Apr 2007
Location: LA LA Land
Posts: 1,607
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I always say that if stress kills you I'd be long dead.
I mean that with all sincerity. I am fired up-a live wire-type A+++passionate-I over react-I worry-I stress-I drey-I agonize-but I also get things accomplished!
Have I mellowed in 50 years? I sure hope so but I've co-existed with stress my whole life. To me - life is kind of stressful (what an understatement).
That's my story and I'm stickin' to it 
__________________
1996 cancer WTF?! 1.3 cm lumpectomy Er/Pr neg. Her2+ (20nodes NEGATIVE) did CMF + rads. NED.
2002 recurrence. Bilateral mastectomy w/TFL autologous recon. Then ACx2. Skin lymphatic rash. Taxotere w/Herceptin x4. Herceptin/Xeloda. Finally stops spreading.
2003 - Back to surgery, remove skin mets, and will have surgery one week later when pathology can confirm margins.
‘03 latisimus dorsi flap to remove skin mets. CLEAN MARGINS. Continue single agent Herceptin thru 4/04. NED.
‘04 '05 & 06 tiny recurrences - scar line. surgery to cut out. NED each time.
1/2006 Rads again, to scar line. NED.
3/07 Heartbreaking news - mets! lungs.sternum. Try Tykerb/Xeloda. Tykerb/Carbo/Gemzar. Switch Oncs.
12/07 Herceptin.Tykerb. Markers go stable.
2/8/08 gamma knife 13mm stupid brain met.
3/08 Herceptin/tykerb/avastin/zometa.
3/09 brain NED. Lungs STABLE.
4/09 attack sternum (10 daysPHOTONS.5 days ELECTRONS)
9/09 MARKERS normal!
3/10 PET/CT=manubrium intensely metabolically active but stable. NEDhead.
Wash out 5/10 for tdm1 but 6/10 CT STABLE, PET improving. Markers normal. Brain NED. Resume just Herceptin plus ZOMETA
Dec 2010 Brain NED, lungs/sternum stable. markers normal.
MAR 2011 stop Herceptin/allergy! Go back on Tykerb and switch to Xgeva.
May-Aug 2011 Tykerb Herceptin Xgeva.
Sept 2011 Tykerb, Herceptin, Zometa, Avastin.
April 2012 sketchy drug trial in NYC. 6 weeks later I’m NED!
OCT 2012 PET/CT shows a bunch of freakin’ progression. Back to LA and Herceptin.avastin.zometa.
12/20/12 add in PERJETA!
March 2013 – 5 YEARS POST continue HAPZ
APRIL 2013 - 6 yrs stage 4. "FAILED" PETscan on 4/2/13
May 2013: rePetted - improvement in lungs, left adrenal stable, right 6th rib inactive, (must be PERJETA avastin) sternum and L1 fruckin'worsen. Drop zometa. ADD Xgeva. Doc says get rads consultant for L1 and possible biopsy of L1. I say, no thanks, doc. Lets see what xgeva brings to the table first. It's summer.
June-August 2013HAPX Herceptin Avastin Perjeta xgeva.
Sept - now - on chemo hold for calming tummy we hope. Markers stable for 2 months.
Nov 2013 - Herceptin-Perjeta-Avastin-Xgeva (collageneous colitis, which explains tummy probs, added Entocort)
December '13 BRAIN MRI ned in da head.
Jan 2014: CONTINUING on HAPX…
FEB 2014 PetCT clinical “impression”: 1. newbie nodule - SUV 1.5 right apical nodule, mildly hypermetabolic “suggestive” of worsening neoplastic lesion. 2. moderate worsening of the sternum – SUV 5.6 from 3.8
3. increasing sclerosis & decreasing activity of L1 met “suggests” mild healing. (SUV 9.4 v 12.1 in May ‘13)
4. scattered lung nodules, up to 5mm in size = stable, no increased activity
5. other small scattered sclerotic lesions, one in right iliac and one in thoracic vertebral body similar in appearance to L1 without PET activity and not clearly pathologic
APRIL 2014 - 6 YRS POST GAMMA ZAP, 7 YRS MBC & 18 YEARS FROM ORIGINAL DX!
October 2014: hold avastin, continue HPX
Feb 2015 Cancer you lost. NEDHEAD 7 years post gamma zap miracle, 8 years ST4, +19 yrs original diagnosis.
Continue HPX. Adding back Avastin
Nov 2015 pet/ct is mixed result. L1 SUV is worse. Continue Herceptin/avastin/xgeva. Might revisit Perjeta for L1. Meantime going for rads consult for L1
December 2015 - brain stable. Continue Herceptin, Perjeta, Avastin and xgeva.
Jan 2016: 5 days, 20 grays, Rads to L1 and continue on HAPX. I’m trying to "save" TDM1 for next line. Hope the rads work to quiet L1. Sciatic pain extraordinaire :((
Markers drop post rads.
2/24/16 HAP plus X - markers are down
SCIATIC PAIN DEAL BREAKER.
3/23/16 Laminectomy w/coflex implant L4/5. NO MORE SCIATIC PAIN!!! Healing.
APRIL 2016 - 9 YRS MBC
July 2016 - continue HAP plus Xgeva.
DEC 2016 - PETCT: mets to sternum, lungs, L1 still about the same in size and PET activity. Markers not bad. Not making changes if I don't need to. Herceptin/Perjeta/Avastin/Xgeva
APRIL 2017 10 YEARS MBC
December 2017 - Progression - gonna switch it up
FEB 2018 - Kadcyla 3 cycles ---->progression :(
MAY30th - bronchoscopy, w/foundation1 - her2 enriched
Aug 27, 2018 - start clinical trial ZW25
JAN 2019 - ZW25 seems to be keeping me stable
APRIL 2019 - ONE DOZEN YEARS LIVING METASTATIC
MAY 2019 - progression back on herceptin add xeloda
JUNE 2019 - "6 mos average survival" LMD & CNS new single brain met - one zap during 5 days true beam SBRT to cord met
10/30/19 - stable brain and cord. progression lungs and bones. washing out. applying for ds8201a w nivolumab. hope they take me.
12/27/19 - begin ds8401a w nivolumab. after 2nd cycle nodes melt away. after 3rd cycle chest scan shows Improvement, brain MRI shows improvement, resolved areas & nothing new. switch to plain ENHERTU. after 4th cycle, PETscan shows mostly resolved or improved results. Markers near normal. I'm stunned but grateful.
10/26/20 - June 2021 Tucatinib/xeloda/herceptin - stable ish.
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05-22-2008, 05:59 PM
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#3
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Senior Member
Join Date: Apr 2007
Posts: 292
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You are absolutely correct on the caveman thing--people been stressing for centuries!
When I started having panic attacks, I needed to know what caused them. So, I looked up the parasympathetic and sympathetic nervous systems and how they worked. A caveman's flight or flight response was how it was explained...
Legs feeling like jell-o? Rushing blood so that you could run away faster (from the T-Rex--okay, I am not sure that cavemen and T-Rexs co-existed, but it's a good visual).
Eyesight getting funky? Cornea opening to let in more light so that you can see where you are running!
Hands getting sweaty? Harder for a saber-toothed tiger to hold on to your arm.
Heart beating 90 miles a minute? A rush of adrenaline to, once again, help you run away (from the pteradactyl this time).
It's funny how it all works, and pretty interesting. For me, knowing what the systems were doing and how they worked with each other, helped me to stop being anxious about being anxious!
I swear, a panic attack is the most cardiac workout I get these days. Tee-hee.
__________________
Krista
Diagnosed 3/29/2007 @ age 34
Stage 1, Node Neg. (SNB), Grade 2, 1.4 cm. IDC
ER/PR 90%+ HER2 +
6 TCH started 5/25/2007, ended after #5 due to steroid "reactions" and neuropathy in feet and hands
BUT--#6 CH w/o Taxotere
Begin Herceptin alone 9/28/2007
30 rads completed 12/19/2007
Finish Herceptin 5/9/2008
Stopped Tamoxifen early--HATED it.
Married 17 years
13-year old son
3 embies on ice (from 1999)
GA, USA
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05-22-2008, 06:15 PM
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#4
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Senior Member
Join Date: Nov 2007
Location: Connecticut
Posts: 2,077
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Really good post, Jean. Got us thinking, and I think you are right. Flori and Krista, you guys have made very good points, too. Interesting. Peace and Love, Bill
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05-23-2008, 12:32 AM
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#5
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Senior Member
Join Date: Mar 2007
Location: Hilo, Hawaii
Posts: 1,867
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I think there is a difference between acute stress and chronic stress. With acute stress I feel there are physiological changes that occur giving a person added energy, mental sharpness and strength. I think chronic stress has the potential of becoming physiologically debilitating and immune compromising. Therefore, I think it is wise to be able to analyse the acute stress in a way in which it does not become chronic if possible.
__________________
*** MARYANNE *** aka HARRIECANARIE
1993: right side DCIS, lumpectomy, rads
1999: left side DCIS, lumpectomy, rads, tamoxifen
2006:
BRCA 2 positive
Stage I, invasive DCIS (6mm x 5mm)
Grade: intermediate
sentinal node biopsy: neg
HER2/neu amplified 4.7
ER+/PR+
TOPO II neg
Oncotype dx 20
Bilat mastectomy with DIEP flap reconstruction
oophorectomy
2007:
6 cycles TCH (taxotere, carboplatin, herceptin)
finished 1 yr herceptin 05/07
Arimidex, stopped after almost 1 yr
Femara
Last edited by harrie; 05-23-2008 at 12:35 AM..
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05-23-2008, 06:00 AM
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#6
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Senior Member
Join Date: Apr 2007
Posts: 292
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Haaay, Harrie!
I agree. Mine used to be "normal", then "problematic", then "normal", then "uh-oh problematic" (that's the BC diagnosis), and now it's just part of life and seems pretty normal for all that I worry about!
Take care,
__________________
Krista
Diagnosed 3/29/2007 @ age 34
Stage 1, Node Neg. (SNB), Grade 2, 1.4 cm. IDC
ER/PR 90%+ HER2 +
6 TCH started 5/25/2007, ended after #5 due to steroid "reactions" and neuropathy in feet and hands
BUT--#6 CH w/o Taxotere
Begin Herceptin alone 9/28/2007
30 rads completed 12/19/2007
Finish Herceptin 5/9/2008
Stopped Tamoxifen early--HATED it.
Married 17 years
13-year old son
3 embies on ice (from 1999)
GA, USA
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05-23-2008, 07:41 AM
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#7
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Senior Member
Join Date: Jan 2007
Location: UK
Posts: 617
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humm ..sorry but I will have to add to your thoughts from a biologist point of view:
In biology the stress stimulus which causes teh 'fight or flight' answer is indeed a useful survival tool..except that in todays society we are not fighting nor flying away instead we internalise...and that is not good (chronic stress). Sport is a good release .
Wind "stress" is a physical force, when you train at the gym you become physically stronger. It has nothing to do with psychological stress.
__________________

35 y/o
June 06: BC stage I
Grade 3; ER/PR neg
Her-2+++; lumpectomies
Aug 06: Stage IV
liver mets: 6 tumours
July 06 to Jan 07: 2*FEC+6*Taxotere; 3*TACE; LITT
March 07- Sept 07: Vaccination trial (phase 2, peptide based) at the UW (Seattle).
Herceptin since 2006
NED til Oct 09
Recurrence Oct 2009: to internal mammary gland since October 2009 missed on Oct and March 2010 scan.. palpable nodes in May 2010 when I realised..
Nov 2011:7 mets to lungs progressing fast failed hercp/tykerb/xeloda combo..
superior vena cava blocked: stent but face remains puffy
April 2012: Teresa Trial, randomised to TDM1
Nov 2012 progressing on TDM1
Dec 2012 blockage of my airways by tumours, obliteration of these blocking tumours breathing better but hoping for more- at mo too many tumours to count in the lungs and nodes.
Dec 2012 Starting new trial S-222611 phase 1b dual egfr her2+ inhibitor.
'Under no circumstances should you lose hope..' Dalai Lama
Last edited by fullofbeans; 05-23-2008 at 07:58 AM..
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05-23-2008, 08:37 AM
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#8
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Senior Member
Join Date: Oct 2005
Location: New Jersey
Posts: 3,154
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Fullofbeans,
Yes, of course you are correct - from a biologist point of view....
My post was purely inspirational - the members have expierenced so much loss in the past few weeks and
it has been very sad and stressful to all. My post was meant to be inspirational in nature ...to help lighten up
the heavy hearts of many of us and those who are fighting so hard each day.
I do believe that even in todays world (cancer dx. or not) people face many problems and not everyone internalises stress. There are those who are motivated by it, become stronger, even angry which is a good emotion, like I am angry at cancer - and want to kick it in the pants for good.
As Flori stated she lives with stress as part of life (cancer or not) maybe Darwins
therory must be employed a bit also....in any event, it is an interesting topic
how different people respond to stress. Some fight back while others maybe more fragile in temperment do not? In life and business I see many different forms and levels of stress. Some handle it better than others...as I said my post was intended for pure inspirational intentions. Also my admiration to those members who are our heros....and are like the tree that digs in deep and stands strong and tall.
Jean
__________________
Stage 1, Grade 1, 3/30/05
Lumpectomy 4/15/05 - 6MM IDC
Node Neg. (Sentinel node)
ER+ 90% / PR-, Her2+++ by FISH
Ki-67 40%
Arimidex 5/05
Radiation 32 trt, 5/30/05
Oncotype DX test 4/17/06, 31% high risk
TOPO 11 neg. 4/06
Stopped Arimidex 5/06
TCH 5/06, 6 treatments
Herceptin 5/06 - for 1 yr.
9/06 Completed chemo
Started Femara Sept. 2006
Last edited by Jean; 05-23-2008 at 10:05 AM..
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05-23-2008, 11:13 AM
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#9
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Senior Member
Join Date: Mar 2007
Location: Hilo, Hawaii
Posts: 1,867
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Krista, to me that was the roller coaster ride. Going from "normal" to crisis, then dealing with the problem, then accepting or working with the situation ( the point when attitude plays an active role in determining whether the situation is acute stress or chronic stress or a recognizable situation that is being dealt with)
__________________
*** MARYANNE *** aka HARRIECANARIE
1993: right side DCIS, lumpectomy, rads
1999: left side DCIS, lumpectomy, rads, tamoxifen
2006:
BRCA 2 positive
Stage I, invasive DCIS (6mm x 5mm)
Grade: intermediate
sentinal node biopsy: neg
HER2/neu amplified 4.7
ER+/PR+
TOPO II neg
Oncotype dx 20
Bilat mastectomy with DIEP flap reconstruction
oophorectomy
2007:
6 cycles TCH (taxotere, carboplatin, herceptin)
finished 1 yr herceptin 05/07
Arimidex, stopped after almost 1 yr
Femara
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05-23-2008, 11:51 PM
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#10
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Senior Member
Join Date: Mar 2007
Location: Hilo, Hawaii
Posts: 1,867
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Fullofbeans, a response to your post about psychological vs physiological stress....
Would you not agree though that psychological stress certainly has a physiological impact on the body? Like for example, under stress, different chemicals are released in various parts of the body, not to mention impacting the immune system. Also, muscles and circulation are effected by mental stress.
I agree, the stress one's body endures during workouts in the gym is a type of stress on the body, but to me that does not mean that psychological, mental, stress does not have its own physiological impaction.
What do you think?
__________________
*** MARYANNE *** aka HARRIECANARIE
1993: right side DCIS, lumpectomy, rads
1999: left side DCIS, lumpectomy, rads, tamoxifen
2006:
BRCA 2 positive
Stage I, invasive DCIS (6mm x 5mm)
Grade: intermediate
sentinal node biopsy: neg
HER2/neu amplified 4.7
ER+/PR+
TOPO II neg
Oncotype dx 20
Bilat mastectomy with DIEP flap reconstruction
oophorectomy
2007:
6 cycles TCH (taxotere, carboplatin, herceptin)
finished 1 yr herceptin 05/07
Arimidex, stopped after almost 1 yr
Femara
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