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05-15-2008, 03:16 PM
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#1
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Senior Member
Join Date: Sep 2005
Posts: 182
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any Stage IV ever have benign liver lesions
I am so scared, just got a message that my 6mo routine CT scan shows two 15mm liver lesions in my remaining right lobe. They are described as hypodense indeterminate. I have a PET scheduled for monday morning.
Has anyone ever had this not be a recurrence? This will now be the third time I have gotten the "dreaded" call. I've been 15 months NED since my liver resection and I really thought I had beat the beast, as I had almost made it 4 years on only Herceptin and and an AI without it showing up anywhere else other than the original left lobe which they removed. My CTC's have remained at 0 the entire time so I was really thinking we were keeping everything mopped up. How these stinking cells can hibernate for so long is really amazing.
I keep hoping that maybe it is some type of scare tissue or something.....or could I develop a simple cyst in the regenerated lobe. It's hard to be positive given my track record......so if you ever had a Pet for liver lesions and had it be fine after all I would sooooo much love to hear from you.
I guess I need to start following the latest trials again too, so let me here what's new for liver mets.
I am so sad tonight but I know I will somehow find a way to pick myself up and battle this yet again.
take care all
kk1
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KK1
April 2004 de novo metastatic left breast 1.5cm her2++,er+/pr+ with 2 small liver mets
weekly taxotere,herceptin, xeloda
Sept 2004 NED-3 herceptin, zoladex,aromasin
Dec 2006 recurrence in liver
Feb. 2007 liver resection left lobe removed-herceptin, zoladex, switch to Arimidex
NED 16 months added zometa
May 2008 new lesion in liver 15mm Tykerb/Xeloda/Herceptin
July 2008 stable...yeah!
Sept 2008 NED again !!!
Jan 2009 fell off the wagon again spot back in the liver and fell out of menopause.
Feb 2009 RFA and 2nd liver resection to remove spot ---back on the NED wagon again continue Tykerb, Herceptin.
March 2009- oophrectomy added Femara and bi-annual Zometa
May 2009- scans clear but suspect lung nodule
June 2009- Lung VAT wedge resection to remove nodule---fungus ball not cancer!! phew
Aug 2009- NED
Nov 2009-scans again clear YAHOO!
March 2010- scans clear continue Tykerb, Herceptin, Femara, Zometa Q6mo
Nov 2009-Nov 2019 scans clear done every 6 months
Feb 2020 - Fell out of the NED wagon hard! single liver lesions and large infect cyst. 3 weeks in ICU.
March 2021- 5 cycles perjeta, herceptin, navelbine. lesion stable.
June 2021 - 3rd liver resection to remove single liver lesion. Continued perjeta, herceptin.
Nov. 2021- PET scan show 5 hot nodes near liver. 9 cycles Kadcyla
June 2021- PET scan shows progression. nodes size unchanged but even more SUV uptake.
July 2021- start ENHERTU
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05-15-2008, 07:05 PM
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#2
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Senior Member
Join Date: Oct 2007
Posts: 1,851
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In 2005 I had a CT scan of chest, abdomen and liver which showed a nodule in my liver. The report recommended a follow-up MRI of the liver, which showed the nodule to be focal fatty tissue.
I had had previous CT scans of the abdomen, but the liver never showed any nodules.
I can understand your concern, but it could be something like a fatty nodule especially since you've been taking a lot of anti-cancer drugs.
My liver counts, etc. were normal.
I'm praying that all will be well for you and you'll continue to be NED.
__________________
Diagnosed stage 2b in July 2003 (2.3 cm, HER2+, ER-/PR-, 7+ nodes). Treated with mastectomy (with immediate DIEP flap reconstruction), AC + T/Herceptin (off label). Cancer advanced to lung in Jan. 2007 (1 cm nodule). Started Herceptin every 3 weeks. Lung wedge resection April 2007. Cancer recurred in lung April 2008. RFA of lung in August 2008. 2nd annual brain MRI in Oct. 2008 discovered 2.6 cm cystic tumor in left frontal lobe. Craniotomy Oct. 2008 (ER-/PR-/HER2-) followed by targeted radiation (IMRT). Coughing up blood Feb. 2009. Thoractomy July 2009 to cut out fungal ball of common soil fungus (aspergillus) that grew in the RFA cavity (most likely inhaled while gardening). No cancer, only fungus. Removal of tiny melanoma from upper left arm, plus sentinel lymph node biopsy in Feb. 2016. Guardant Health liquid biopsy in Feb. 2016 showed mutations in 4 subtypes of TP53. Repeat of Guardant Health biopsy in Jana. 2021 showed 3 TP53 mutations, BRCA1 mutation and CHEK2 mutation. Invitae genetic testing showed negative for all of these. Living with MBC since 2007. Stopped Herceptin Hylecta (injection) treatment in March 2020. Recent 2021 annual CT of chest, abdomen and pelvis and annual brain MRI showed NED. Praying for NED forever!!
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05-15-2008, 09:51 PM
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#3
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Senior Member
Join Date: Sep 2005
Location: Central Coast, CA
Posts: 3,207
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Sorry, I'm not a poster child for the result you are hoping for on the PET, but try not to panic. It could be a cyst or something else not cancer related. I see you suggest that it might be "scare" tissue - I know that's a typo, but it is an accurate description anyway, isn't it.
Whatever news you get with the next scan, it is information you need - either that you can breathe easy again, or that you need to suit up again for the battle. If that's the case, you've been there before and you of course know that you have lots of options.
Several people here have been researching a new treatment which involves radioactive spheres placed in the liver (I think it's called SIRT), there's also RFA and of course lots of "chemical weapons". If need be, you will be able to find out about all of that.
Based on what has been seen on the CT, your oncologist will probably say you have "minimal disease" - that drives me crazy because of course from my perspective even one cancer cell is too many - but this means you have options and time to consider them.
Hang in there...and please let us know what you learn.
love,
Chris
__________________
Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial
5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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05-16-2008, 11:21 PM
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#4
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Junior Member
Join Date: Mar 2007
Posts: 3
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Hi, I also had "something" on my liver according to CT scans for about 9-12 months. It is now gone.
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05-20-2008, 09:09 AM
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#5
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Senior Member
Join Date: Sep 2005
Posts: 182
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it's back
My dancing partner left me again ;(.
Got the PET results, the good news is that only 1 of the 2 lesions showed activity. The strange news is that they see activity on my Thyroid too. I am guessing it's relatd to my Hyshimoto disease where my immune system attacks my throid....bit they are not sure so I am now off to see an endocrinologist too.
It will be Tykerb/Xeloda for me.
__________________
KK1
April 2004 de novo metastatic left breast 1.5cm her2++,er+/pr+ with 2 small liver mets
weekly taxotere,herceptin, xeloda
Sept 2004 NED-3 herceptin, zoladex,aromasin
Dec 2006 recurrence in liver
Feb. 2007 liver resection left lobe removed-herceptin, zoladex, switch to Arimidex
NED 16 months added zometa
May 2008 new lesion in liver 15mm Tykerb/Xeloda/Herceptin
July 2008 stable...yeah!
Sept 2008 NED again !!!
Jan 2009 fell off the wagon again spot back in the liver and fell out of menopause.
Feb 2009 RFA and 2nd liver resection to remove spot ---back on the NED wagon again continue Tykerb, Herceptin.
March 2009- oophrectomy added Femara and bi-annual Zometa
May 2009- scans clear but suspect lung nodule
June 2009- Lung VAT wedge resection to remove nodule---fungus ball not cancer!! phew
Aug 2009- NED
Nov 2009-scans again clear YAHOO!
March 2010- scans clear continue Tykerb, Herceptin, Femara, Zometa Q6mo
Nov 2009-Nov 2019 scans clear done every 6 months
Feb 2020 - Fell out of the NED wagon hard! single liver lesions and large infect cyst. 3 weeks in ICU.
March 2021- 5 cycles perjeta, herceptin, navelbine. lesion stable.
June 2021 - 3rd liver resection to remove single liver lesion. Continued perjeta, herceptin.
Nov. 2021- PET scan show 5 hot nodes near liver. 9 cycles Kadcyla
June 2021- PET scan shows progression. nodes size unchanged but even more SUV uptake.
July 2021- start ENHERTU
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05-20-2008, 11:18 AM
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#6
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Senior Member
Join Date: Jul 2007
Location: Northern California
Posts: 764
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Dear KK1,
Sorry it came back. But you beat if before and you can do it again. I hear Xeloda and Tykerb is a very good combo.
Take care,
Tonya
__________________
DX 02/01/07
2.5 cm, Er/Pr-, Her2+++
18/20 Nodes
03/07 CT & Bone scan - Clear
AC x 4, Taxol x 4, Added Herceptin
Radiation until 09/07
Herceptin every 3 weeks until 06/08
01/10/08 local recurrence -IBC
01/28/08 CT & Brain MRI - clear
02/08 - Navelbine & Herceptin
05/08 -MRM
05/08 - Gemzar & Herceptin - didn't work
09/08 - Hyperthermia rads
03/09 - Tykerb/Xeloda
05/10 - Tram flap to fix wound
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05-20-2008, 02:18 PM
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#7
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Senior Member
Join Date: Nov 2005
Location: Ireland
Posts: 3,463
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I'm sorry too this was not the news you wanted to hear and just wanted to wish you well as you face this new "bump"...I hope the regime you're starting will have you back to NED in no time.
__________________
Tricia
Dx July '05 IDC 1.9cm Triple positive 3/9 nodes positive
A/C X 4 ..Taxol/Herceptin x 12 wks then herceptin 1 yr
Rads x 36 ..oophorectomy August '06
Currently taking Arimidex..
June 2011 osteopenia/ zometa x1 yearly- stopped Zometa 2015 as Dexa show normal bone density.
Stopped Arimidex July 2014- Restarted Arimidex 2015 for a further two years on the advice of my Onc.
2014 Normal Dexa scan
2018 Mammo all clear, still NED!
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05-23-2008, 08:07 AM
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#8
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Senior Member
Join Date: Jan 2007
Location: UK
Posts: 617
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Dearest KK1,
I am so so sorry about your terrible news. I take this very personally indeed.
There was an article not so long ago that showed how laser treatment were as effective as surgery (but as you know from seeing me) much less invasive and could be out of the hospital the same day. It may be something you may wish to consider once tumours under control with chemo combo.
Lots of love and a big hug
__________________
35 y/o
June 06: BC stage I
Grade 3; ER/PR neg
Her-2+++; lumpectomies
Aug 06: Stage IV
liver mets: 6 tumours
July 06 to Jan 07: 2*FEC+6*Taxotere; 3*TACE; LITT
March 07- Sept 07: Vaccination trial (phase 2, peptide based) at the UW (Seattle).
Herceptin since 2006
NED til Oct 09
Recurrence Oct 2009: to internal mammary gland since October 2009 missed on Oct and March 2010 scan.. palpable nodes in May 2010 when I realised..
Nov 2011:7 mets to lungs progressing fast failed hercp/tykerb/xeloda combo..
superior vena cava blocked: stent but face remains puffy
April 2012: Teresa Trial, randomised to TDM1
Nov 2012 progressing on TDM1
Dec 2012 blockage of my airways by tumours, obliteration of these blocking tumours breathing better but hoping for more- at mo too many tumours to count in the lungs and nodes.
Dec 2012 Starting new trial S-222611 phase 1b dual egfr her2+ inhibitor.
'Under no circumstances should you lose hope..' Dalai Lama
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05-23-2008, 10:54 AM
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#9
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Senior Member
Join Date: May 2006
Posts: 3,142
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liver lesions
Hi,
Hang in there. By the way, maybe you will want to ask the doc about your liver enzymes in your blood chemistry (CMP) blood test. If something not so nice is going on in your liver the liver enzymes might be abnormal.
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