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05-14-2008, 06:34 PM
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#1
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Senior Member
Join Date: Sep 2005
Posts: 589
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T-DM1: 1st scans, tm's and side effect
TM's came down close to 50% and CAT showed about 30% reduction!!! We're happy with the start and hope and pray it continues to get better and better.
On the not so great side, Caryn had to miss todays treatment due to high liver function and her eyes are really bothering her. The opthamologist said that the treatment has caused some bumps on her cornea that is causing some bad burning. Not typical for this treatment but it's there for her. She's a trooper and the good news makes it more tolerable.
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05-14-2008, 06:42 PM
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#2
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Senior Member
Join Date: Oct 2007
Posts: 1,851
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Eric, I'm praying that Caryn will be NED and that her eyes will be okay. Best, Joan
__________________
Diagnosed stage 2b in July 2003 (2.3 cm, HER2+, ER-/PR-, 7+ nodes). Treated with mastectomy (with immediate DIEP flap reconstruction), AC + T/Herceptin (off label). Cancer advanced to lung in Jan. 2007 (1 cm nodule). Started Herceptin every 3 weeks. Lung wedge resection April 2007. Cancer recurred in lung April 2008. RFA of lung in August 2008. 2nd annual brain MRI in Oct. 2008 discovered 2.6 cm cystic tumor in left frontal lobe. Craniotomy Oct. 2008 (ER-/PR-/HER2-) followed by targeted radiation (IMRT). Coughing up blood Feb. 2009. Thoractomy July 2009 to cut out fungal ball of common soil fungus (aspergillus) that grew in the RFA cavity (most likely inhaled while gardening). No cancer, only fungus. Removal of tiny melanoma from upper left arm, plus sentinel lymph node biopsy in Feb. 2016. Guardant Health liquid biopsy in Feb. 2016 showed mutations in 4 subtypes of TP53. Repeat of Guardant Health biopsy in Jana. 2021 showed 3 TP53 mutations, BRCA1 mutation and CHEK2 mutation. Invitae genetic testing showed negative for all of these. Living with MBC since 2007. Stopped Herceptin Hylecta (injection) treatment in March 2020. Recent 2021 annual CT of chest, abdomen and pelvis and annual brain MRI showed NED. Praying for NED forever!!
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05-14-2008, 08:16 PM
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#3
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Senior Member
Join Date: Mar 2007
Location: CHARLOTTE NC USA
Home town (ECUADOR) South America
Posts: 542
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the important things here is the tumors markets when down 50% and 30% of reduction .....great ...and the fever soon is going to be bye bye too ....
__________________
Lily Diag April/06 5 months after give birth my son Max stage IV mets on liver (5 tumors) 38 year old, her2+++ and ER+PR+ from32 nodes 4 positives mastectomy right breast chemo before surgery herceptin/carboplatin/taxotere ,clear and surgery have radiation 20, `& then herceptin and tamoxifen NED until Aug/07 body only then 'n June 04-06-07 .1 lesion of 1.6 cm on cerebellum ...novalis ,open sugery 5m.m brain met again novalis, 4mm.In the liver. Waiting 2 months now 3 tumors enroll on T-MCC trial start first infusion Nov 5/07 at Dec 17 scan show one tumor despair the 2nd and 3th diminish Doc said great results until March/08 ct scan show progression 03-05-08 start tykerb & xeloda
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05-14-2008, 08:58 PM
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#4
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Senior Member
Join Date: Sep 2005
Location: Central Coast, CA
Posts: 3,207
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Eric, that's great news! This stuff is pretty darn powerful, and I know you must be really heartened by the results so far.
I also have been dealing with elevated liver markers since starting this trial. They have never come back to anywhere near normal, but are now at least back in a "grade 1" toxicity range. I've not had to skip a treatment (not yet anyway!) but I know that one of the options in the trial is that your doctor can decide that a 28 day cycle would be safer and go with that. It might give a little more time to recover.
Interesting comment on the eye problems. I've also had problems with one eye since starting this, they thought it was maybe some conjunctivitis, but it sounds like a visit to the eye doctor is in order. So, it seems Caryn and I may both have stumbled upon a lesser known side effect.
I hope Caryn continues to feel well and can get back on a treatment schedule soon. You didn't mention fever in this post, but my experience has been I would feel feverish about 1-2 says after treatment, but this diminished with each treatment. Last week I couldn't get that lousy thermometer over 98.4. So no more laying around collecting sympathy for me!
Thanks for posting your update!
__________________
Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial
5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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05-14-2008, 09:10 PM
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#5
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Senior Member
Join Date: Jan 2007
Location: Thornhill, Ontario
Canada
Posts: 2,320
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Great news Eric - Thanks for sharing, as we LOVE to hear good news. I hope Caryn's eye and liver function problems improve ASAP.
all the best
caya
__________________
ER90%+/PR 50%+/HER 2+
1.7 cm and 1.0 cm.
Stage 1, grade 2, Node Negative (16 nodes tested)
MRM Dec.18/06
3 x FEC, 3 x Taxotere
Herceptin - every 3 weeks for a year, finished May 8/08
Tamoxifen - 2 1/2 years
Femara - Jan. 1, 2010 - July 18, 2012
BRCA1/BRCA2 Negative
Dignosed 10/16/06, age 48 , premenopausal
Mild lymphedema diagnosed June 2009 - breast surgeon and lymph. therapist think it's completely reversible - hope so.
Reclast infusion January 2012
Oopherectomy October 2013
15 Years NED!!
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05-15-2008, 10:36 AM
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#6
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Senior Member
Join Date: Sep 2005
Posts: 556
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Great news Eric. Wishing continuous improvement and total NED by the end of the trial.
Julie
__________________
Diagnosed in Sept 2004 while pregnant with the second child. Stage 3b, tumor 4.5cm, 4 auxillary and supraclav node positive. Her2+++ FISH 9.4 and er-,pr-.
Had dose dense neoadjuvant AC,Taxol then mastectomy,radiation+xeloda+Herceptin.
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05-15-2008, 01:46 PM
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#7
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Senior Member
Join Date: Sep 2007
Location: Tampa, FL
Posts: 43
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I to just had my 4th T-DM1 treatment. All is going well, my tumors have gone away completly. Interesting regarding the eyes. I have been having trouble as well. I'm 45, and I just thought maybe my age was the problem. Guess I better make an appointment and get this checked out.
Thanks for sharing.
-Verna
__________________
stage IV, diagnosed Nov.11,2005
mets to spine,hips,pelvic,femur
4 a/c
mastectomy Feb.14,2006
4 taxol
mets to liver
5 weeks radiation
Herceptin/Zometa
reconstruction Feb.14,2007 (DEIP)
Tykerb/Xeloda
TDM1 study
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05-15-2008, 08:03 PM
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#8
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Senior Member
Join Date: Nov 2004
Posts: 190
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Eric,
I was thinking about you guys. I'm glad things are going well!!! I'm sending positive vibes
Kim
__________________
8/98 dx right breast
5/2003 tram flap right breast
8/2004 dx new primary left breast with inflammatory bc
er/pr-, her2neu+++
8/19 taxotere and herceptin
1/15/2005 Navelbine/Herceptin
4/2005 radiation and Herceptin
5/15/2005 Herceptin alone
2/12/2008 skin biopsy positive
2/14/2008 met to sternum, possibly right breast
2/27/08 Start omitarg, herceptin, taxotere trial
3/17/08 Kicked off trial because I started too close to my last herceptin
3/19 start tykerb xeloda
Right breast confirmed met
5/15/08 skin mets gone, no hypermetabolic activity in breast, sternum healing
8/24/08 scans still look good. sternum still active with scarring. No evidence of progression
10/08 Progression in sternum
12/08 Start TDM1 trial
1/09 Scans show stable
12/09 1 year on TDM1 still stable
10/10 progression in chest and liver
11/10 false positive of liver mets; tykerb and herceptin
4/11 Tykerb/Herceptin/Xgeva
4/11 Rads to Sternum
5/12/12 NED Herceptin/Zometa
3/16/19 still NED Herceptin/Zometa very 6months
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05-15-2008, 11:10 PM
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#9
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Senior Member
Join Date: Oct 2005
Posts: 3,519
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Yeah RunDMC1 trial! So what are the components in the trial besides Herceptin?
__________________
Brenda
NOV 2012 - 9 yr anniversary
JULY 2012 - 7 yr anniversary stage IV (of 50...)
Nov'03~ dX stage 2B
Dec'03~ Rt side mastectomy, Her2+, ER/PR+, 10 nodes out, one node positive
Jan'04~ Taxotere/Adria/Cytoxan x 6, NED, no Rads, Tamox. 1 year, Arimadex 3 mo., NED 14 mo.
Sept'05~ micro mets lungs/chest nodes/underarm node, Switched to Aromasin, T/C/H x 7, NED 6 months - Herceptin only
Aug'06~ micro mets chest nodes, & bone spot @ C3 neck, Added Taxol to Herceptin
Feb'07~ Genetic testing, BRCA 1&2 neg
Apr'07~ MRI - two 9mm brain mets & 5 punctates, new left chest met, & small increase of bone spot C3 neck, Stopped Aromasin
May'07~ Started Tykerb/Xeloda, no WBR for now
June'07~ MRI - stable brain mets, no new mets, 9mm spots less enhanced, CA15.3 down 45.5 to 9.3 in 10 wks, Ty/Xel working magic!
Aug'07~ MRI - brain mets shrunk half, NO NEW BRAIN METS!!, TMs stable @ 9.2
Oct'07~ PET/CT & MRI show NED
Apr'08~ scans still show NED in the head, small bone spot on right iliac crest (rear pelvic bone)
Sept'08~ MRI shows activity in brain mets, completed 5 fractions/5 consecutive days of IMRT to zap the pesky buggers
Oct'08~ dropped Xeloda, switched to tri-weekly Herceptin in combo with Tykerb, extend to tri-monthly Zometa infusion
Dec'08~ Brain MRI- 4 spots reduced to punctate size, large spot shrunk by 3mm, CT of torso clear/pelvis spot stable
June'09~ new 3-4mm left cerrebellar spot zapped with IMRT targeted rads
Sept'09~ new 6mm & 1 cm spots in pituitary/optic chiasm area. Rx= 25 days of 3D conformal fractionated targeted IMRT to the tumors.
Oct'09~ 25 days of low dose 3D conformal fractionated targeted IMRT to the bone mets spot on rt. iliac crest that have been watching for 2 years. Added daily Aromasin back into treatment regimen.
Apr'10~ Brain MRI clear! But, see new small spot on adrenal gland. Change from Aromasin back to Tamoxifen.
June'10~ Tumor markers (CA15.3) dropped from 37 to 23 after one month on Tamoxifen. Continue to monitor adrenal gland spot. Remain on Tykerb/Herceptin/Tamoxifen.
Nov'10~ Radiate positive mediastinal node that was pressing on recurrent laryngeal nerve, causing paralyzed larynx and a funny voice.
Jan'11~ MRI shows possible activity or perhaps just scar tissue/necrotic increase on 3 previously treated brain spots and a pituitary spot. 5 days of IMRT on 4 spots.
Feb'11~ Enrolled in T-DM1 EAP in Denver, first treatment March 25, 2011.
Mar'11~ Finally started T-DM1 EAP in Denver at Rocky Mountain Cancer Center/Rose on Mar. 25... hallelujah.
"I would rather be anecdotally alive than statistically dead."
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05-16-2008, 07:10 AM
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#10
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Senior Member
Join Date: Jun 2006
Location: San Antonio, TX
Posts: 2,357
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Wonderful news today! Can't wait to hear even more good news from you Eric about Caryn! ma
__________________
MA in TX.
Grateful for each and every day....
Diag. 12/05 at age 60
Stage II, Grade 3, 4.5 cm primary tumor
ER/PR- Her2 +3 strongly positive
Her2 by FISH 7.7 amplified
vascular invasion
Ki67 20% borderline
Jan - March '06 Taxotere/Adriamycin X 3 to try to shrink tumor - it grew
April '06 Rt Modified Radical Mas, 7 of 9 nodes positive
April - Aug. '06 Herceptin/Taxol/Carboplatin X 8 (dose dense)
Sept - Dec. '06 Navelbine/Herceptin x 8 (dose dense)
Radiation & Herceptin Jan. 22 - March 1, 2007
Finished Herceptin Dec. 10 '08! One extra year.
Port removed August, 2012.
8 1/2 years since diagnosis! 5 1/2 Years NED!
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05-16-2008, 11:39 AM
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#11
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Senior Member
Join Date: Sep 2005
Location: Central Coast, CA
Posts: 3,207
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Hutchibk - run dmc1 trial info
Hi Brenda,
Ha ha, I thought I was the only one who called it that! Well, maybe Flori, too - she even had a rap about it...
The drug itself is a herceptin molecule linked to a toxin called DM1. The "linker" molecule is called MCC. So the full name of this crazy ass wonder drug is
Trastuzumab-MCC-DM1.
So, there are 3 components but only one actual drug. Sort of like a reeses peanut butter cup but not as tasty.
The MCC is important because it is the first one that actually worked in the sense of "hanging on" to the toxin long enough to get it into the cancer cells - as opposed to releasing it into the general bloodstream. A critical factor, as the DM1 has had limited usefulness in the past because it is umm TOO TOXIC.
DM1 is in a class of drugs called maytansinoid. It is supposed to be 100x as strong as Vincristine. I heard that during the poster presentation at San Antonio.
It's given in a 1/2 hour infusion but it actually takes an hour because they have to do a blood draw 30 minutes post infusion.
Overall, there seems to me to be a TON of data being collected...weekly labs and lots of blood tests to determine how much of the drug is in the bloodstream (hopefully a lot) and how much "free DM1" is in the bloodstream (hopefully not much). Other than that and the odd bit of liver and platelet toxicity, it's pretty tolerable.
__________________
Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial
5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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05-16-2008, 12:22 PM
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#12
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Senior Member
Join Date: Oct 2005
Location: New Jersey
Posts: 3,154
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Eric and Chrisy,
This trial sounds so hopeful...
Please keep all of us updated and my prayers and healing wishes are with both of you.
Hugs,
Jean
__________________
Stage 1, Grade 1, 3/30/05
Lumpectomy 4/15/05 - 6MM IDC
Node Neg. (Sentinel node)
ER+ 90% / PR-, Her2+++ by FISH
Ki-67 40%
Arimidex 5/05
Radiation 32 trt, 5/30/05
Oncotype DX test 4/17/06, 31% high risk
TOPO 11 neg. 4/06
Stopped Arimidex 5/06
TCH 5/06, 6 treatments
Herceptin 5/06 - for 1 yr.
9/06 Completed chemo
Started Femara Sept. 2006
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05-16-2008, 06:22 PM
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#13
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Senior Member
Join Date: Oct 2005
Posts: 3,519
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Thanks Chrisy... this is one of the things in the 'pipeline' that is on my back burner, should I lose favor with Tykerb/Xeloda...
I am happy to have the info. Does anyone here know the details and status of the Herceptin/Tykerb trials?
__________________
Brenda
NOV 2012 - 9 yr anniversary
JULY 2012 - 7 yr anniversary stage IV (of 50...)
Nov'03~ dX stage 2B
Dec'03~ Rt side mastectomy, Her2+, ER/PR+, 10 nodes out, one node positive
Jan'04~ Taxotere/Adria/Cytoxan x 6, NED, no Rads, Tamox. 1 year, Arimadex 3 mo., NED 14 mo.
Sept'05~ micro mets lungs/chest nodes/underarm node, Switched to Aromasin, T/C/H x 7, NED 6 months - Herceptin only
Aug'06~ micro mets chest nodes, & bone spot @ C3 neck, Added Taxol to Herceptin
Feb'07~ Genetic testing, BRCA 1&2 neg
Apr'07~ MRI - two 9mm brain mets & 5 punctates, new left chest met, & small increase of bone spot C3 neck, Stopped Aromasin
May'07~ Started Tykerb/Xeloda, no WBR for now
June'07~ MRI - stable brain mets, no new mets, 9mm spots less enhanced, CA15.3 down 45.5 to 9.3 in 10 wks, Ty/Xel working magic!
Aug'07~ MRI - brain mets shrunk half, NO NEW BRAIN METS!!, TMs stable @ 9.2
Oct'07~ PET/CT & MRI show NED
Apr'08~ scans still show NED in the head, small bone spot on right iliac crest (rear pelvic bone)
Sept'08~ MRI shows activity in brain mets, completed 5 fractions/5 consecutive days of IMRT to zap the pesky buggers
Oct'08~ dropped Xeloda, switched to tri-weekly Herceptin in combo with Tykerb, extend to tri-monthly Zometa infusion
Dec'08~ Brain MRI- 4 spots reduced to punctate size, large spot shrunk by 3mm, CT of torso clear/pelvis spot stable
June'09~ new 3-4mm left cerrebellar spot zapped with IMRT targeted rads
Sept'09~ new 6mm & 1 cm spots in pituitary/optic chiasm area. Rx= 25 days of 3D conformal fractionated targeted IMRT to the tumors.
Oct'09~ 25 days of low dose 3D conformal fractionated targeted IMRT to the bone mets spot on rt. iliac crest that have been watching for 2 years. Added daily Aromasin back into treatment regimen.
Apr'10~ Brain MRI clear! But, see new small spot on adrenal gland. Change from Aromasin back to Tamoxifen.
June'10~ Tumor markers (CA15.3) dropped from 37 to 23 after one month on Tamoxifen. Continue to monitor adrenal gland spot. Remain on Tykerb/Herceptin/Tamoxifen.
Nov'10~ Radiate positive mediastinal node that was pressing on recurrent laryngeal nerve, causing paralyzed larynx and a funny voice.
Jan'11~ MRI shows possible activity or perhaps just scar tissue/necrotic increase on 3 previously treated brain spots and a pituitary spot. 5 days of IMRT on 4 spots.
Feb'11~ Enrolled in T-DM1 EAP in Denver, first treatment March 25, 2011.
Mar'11~ Finally started T-DM1 EAP in Denver at Rocky Mountain Cancer Center/Rose on Mar. 25... hallelujah.
"I would rather be anecdotally alive than statistically dead."
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05-16-2008, 07:12 PM
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#14
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Senior Member
Join Date: Sep 2005
Posts: 589
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Sorry for the following not so great news but I think it's important to share as someone else might benefit...
Some good news, some not such good news and some positive news...
* Good news: Caryn's 1st scan results came back reinforcing the positive story her tumor markers told us last week. The drugs not only kept the cancer from growing but showed about a 30% shrinkage in certain areas. A GREAT start that everyone's very happy with. YEAAAAHHHH!!!
* Not such good news: Caryn's been having a TERRIBLE time with the treatment. She's had burning in her eyes that has gotten worse over the few weeks and she ended up in the ER last night with terrible chest pain. All tests in the hospital revealed no abnormality in her heart and lungs. Additionally, she had a recent physical where they were concerned about her breathing capacity and recommended that she see a pulmonologist. Between feeling badly physically and the stress and time investment for going into the city each and every week, it's no wonder that Caryn is not a happy camper these days. She has had a difficult time in light and has spent a good deal of time sleeping due to fatigue and the pain in her eyes. The doctor at Sloan heading up this trial hasn't seen this kind of reaction and really had no idea of what was going on so she recommended going to a cardiologist in addition to the pulmonologist.
* Positive news: Caryn went to an Opthamologist for her eyes. This Dr. saw bumps around her corneas but wasn't sure how to proceed so she referred Caryn to a Cornea Specialist. We saw the specialist today who id'd the bumps and feels that they can be managed while continuing her treatment. While still at this specialist, Caryn asked me to call the cardiologist to schedule a stress test and call her primary Onc to get the name of a good pulmonologist. Upon hearing about the series of events and how badly Caryn had been feeling, the Onc INSISTED that Caryn come right in. Thankfully, he seems to have put the pieces together. It appears that the treatment is causing inflamation in Caryn's system. He wants to put her on a brief steroid regimen to reduce the inflamation and prevent any lung damage. He agrees with the decision to see a Pulmonologist and has given her a name. He has also confident that there is no need for a stress test. For now we continue on treatment full steam ahead!
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05-17-2008, 10:35 AM
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#15
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Senior Member
Join Date: Sep 2005
Location: Central Coast, CA
Posts: 3,207
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Eric,
Thanks for the update, I hope Caryn feels better soon. I think this is one of the downsides of early trials - they just don't know what to expect in terms of side effects, so neither do we. Your sharing this is very helpful to those currently in or considering this trial, as it gives us one more piece of information.
Nice to hear Caryn doesn't need a stress test. I think you've had enough stress testing over the past few weeks already.
Hugs
Chris
__________________
Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial
5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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05-18-2008, 12:08 AM
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#16
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Senior Member
Join Date: Nov 2007
Location: Connecticut
Posts: 2,077
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Eric, wow, I feel for you, brother, and Caryn, as well. You both are in my thoughts and prayers. I'm glad to hear about the TM results, but sorry to hear about the eye troubles from you and the other Ladies. Regarding the steroid "thing", Nikki was on Dexamethasone for awhile, and her glucose levels went up to where she required insulin shots, so keep an eye on that, too. She had one failed port removed, and another one installed "next door", and the removal site never healed properly, until she had a few insulin injections, and then she healed right up. Keep fighting the good fight!
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