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04-21-2008, 09:36 AM
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#1
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Senior Member
Join Date: Apr 2006
Location: Wilmington, Del.
Posts: 1,126
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Arimidex - Another side effect
I've posted about the cognitive side effects I've been experiencing. I was talking about them to my BC survivor friend who is taking Arimidex. She told me about her eye troubles -- she feels her eyeballs are swelling - or that there is a lot of pressure on her eyeballs. I was surprised, because I have the same eye trouble. It didn't occur to me it might be Arimidex. I had a checkup at the opthamologist less than a year ago and all was fine. I was ready to make an appointment again with him. Has anyone else on Arimidex had feelings of pressure - swelling in the eyes?
__________________
MJO
IDC, Stage I, Grade 2
Oncotype DX Score 32
Her2++ E+P+, Node Neg.
Lumpectomy 11/04/05 Clear Margins
3 Dose dense AC (Couldn't tolerate 4)
4 Dose dense Taxol & Herc. (Tolerated well)
36 weeks Herceptin (Could not complete one year due to decrease in MUGA score)
2 years of Arimidex, then three years of Femara
Finished Femara May 2011
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04-21-2008, 09:58 AM
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#2
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Senior Member
Join Date: Sep 2005
Location: Stockton, NJ
Posts: 4,179
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I have (and do) but I also did on Tamoxifen. Perhaps it is a side effect of diminshing estrogen levels (or sub levels as theoretically, estrogen should be lower than norm for a postmenopausal woman).
__________________
Kind regards
Becky
Found lump via BSE
Diagnosed 8/04 at age 45
1.9cm tumor, ER+PR-, Her2 3+(rt side)
2 micromets to sentinel node
Stage 2A
left 3mm DCIS - low grade ER+PR+Her2 neg
lumpectomies 9/7/04
4DD AC followed by 4 DD taxol
Used Leukine instead of Neulasta
35 rads on right side only
4/05 started Tamoxifen
Started Herceptin 4 months after last Taxol due to
trial results and 2005 ASCO meeting & recommendations
Oophorectomy 8/05
Started Arimidex 9/05
Finished Herceptin (16 months) 9/06
Arimidex Only
Prolia every 6 months for osteopenia
NED 18 years!
Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"
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04-21-2008, 11:57 AM
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#3
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Senior Member
Join Date: Aug 2006
Posts: 3,380
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There was an Abstract at the last SABCS
about increased frequency of retinal hemorrage among anastrozole users:
http://www.abstracts2view.com/sabcs/...u=SABCS07L_109
Before anyone gets over-alarmed by this title, the authors were starting from the assumption that many ocular problems are menopause related, as there are estrogen receptors in the eye. The premise was that estrogen deprivation, whether natural or chemically induced, would have a similar effect.
The results showed the prevalence rate for hemorrage was significantly greater for anastrozole users than tamoxifen users, with a 95% likelihood the anastrozole prevalence rate was equal to or greater than 4%.
Hopeful |
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04-21-2008, 07:40 PM
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#4
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Senior Member
Join Date: Mar 2006
Posts: 4,783
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at the 2005 SABCS I seem to remember someone from the
Opthalmology Dept of the University of Oregon (I think) who had a poster regarding increased intraocular pressure resulting from the use of AIs, if I recall correctly
Hope this points you in the right direction
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04-22-2008, 12:06 AM
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#5
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Senior Member
Join Date: Mar 2007
Location: Hilo, Hawaii
Posts: 1,867
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I would recommend she go in for a complete eye examination.
Tamoxifen has a rare chance of causing Tamoxifen retinopathy. A toxic reaction to the retina due to the med.
__________________
*** MARYANNE *** aka HARRIECANARIE
1993: right side DCIS, lumpectomy, rads
1999: left side DCIS, lumpectomy, rads, tamoxifen
2006:
BRCA 2 positive
Stage I, invasive DCIS (6mm x 5mm)
Grade: intermediate
sentinal node biopsy: neg
HER2/neu amplified 4.7
ER+/PR+
TOPO II neg
Oncotype dx 20
Bilat mastectomy with DIEP flap reconstruction
oophorectomy
2007:
6 cycles TCH (taxotere, carboplatin, herceptin)
finished 1 yr herceptin 05/07
Arimidex, stopped after almost 1 yr
Femara
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04-22-2008, 05:28 AM
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#6
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Senior Member
Join Date: Apr 2006
Location: Wilmington, Del.
Posts: 1,126
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Thank you. The women at this site have once again given me information I need. I have a checkup with my oncologist next week. I will talk to him about my eyes. He is going to discuss with me going on a clinical trial with Femara that may or may not keep me on AIs for 10 years. I don't know if my eyes and brain can take seven more years of AIs.
__________________
MJO
IDC, Stage I, Grade 2
Oncotype DX Score 32
Her2++ E+P+, Node Neg.
Lumpectomy 11/04/05 Clear Margins
3 Dose dense AC (Couldn't tolerate 4)
4 Dose dense Taxol & Herc. (Tolerated well)
36 weeks Herceptin (Could not complete one year due to decrease in MUGA score)
2 years of Arimidex, then three years of Femara
Finished Femara May 2011
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