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Old 03-12-2008, 03:38 PM   #1
Joe
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Serum HER2/neu Test

Here is a link to the latest info on the HER2 Serum Test:

http://www.medical.siemens.com/webap...Id~e_10001.htm



Regards
Joe
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Old 03-12-2008, 04:25 PM   #2
TSund
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Is this test available now or in the future?

Is it something that might be worthwhile doing on some kind of regular basis for a non-metastatic patient? Perhaps as an alternative to scans?
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Terri, spouse of Ruth, Dallas/Ft. Worth area
Ruth dx 05/01/07 (age 50) Filipino
multifocal, several tumors .5 -2.5 cm, large area
Breast MRI showed 2 enlarged nodes, not palpable
100%ER+, 95%PR+, HER2+++
6x pre-surgery TCH chemo finished 9/15/7 Dramatic tumor shrinkage
1 year Herceptin till 6/08
MRM 10/11/07, SNB: 0/4 nodes + Path: tumors reduced to only a few "scattered cells"
now 50% ER+, PR- ???
Rads finished 1/16/08
Added Tamoxifen,
Finished Herceptin 05/08
NOW is the time to appreciate life to the fullest.
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Old 03-12-2008, 05:26 PM   #3
Lolly
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Thanks Joe, I bookmarked the site....and hey, our Christine is quoted!
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Sept.'99 - Dx.Stage IIIB, IDC ER/PR-, HER2+++ by IHC, confirmed '04 by FISH. Left MRM, AC x's 4, Taxol x's 4, 33 Rads, finishing Tx May 2000. Jan.'01 - local/regional recurrence, Stage IV. Herceptin/Navelbine weekly till NED August 2001, then maintenance Herceptin. Right Mast. April 2002. Local/Regional recurrence April '04, Herceptin plus/minus chemo until May '07. Gemzar added from Feb.'07-April '07; Tykerb/Abraxane until August '07, back on Herceptin plus Taxotere and Xeloda Sept. '07. Stopped T/X Nov. '07, stopped Herceptin Dec. '07, started Avastin/Taxol/Carboplatin Dec. '07. Progression in chest skin, stopped TAC March '03, started radiation.

Herceptin has served as the "Backbone" of my treatment strategy for over 6 years, giving me great quality of life. In 2005, I was privileged to participate in the University of Washington/Seattle HER2 Vaccine Trial.
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Old 03-12-2008, 07:04 PM   #4
Jean
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Yes,

Tsund,
The test is available now and most onc. discourage the test unless you have spread of disease...not so...while in SA we had dinner with the dr.
who invented the test...and he told me early stagers can and should have the test as a base line.

Regards,
Jean
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Stage 1, Grade 1, 3/30/05
Lumpectomy 4/15/05 - 6MM IDC
Node Neg. (Sentinel node)
ER+ 90% / PR-, Her2+++ by FISH
Ki-67 40%
Arimidex 5/05
Radiation 32 trt, 5/30/05
Oncotype DX test 4/17/06, 31% high risk
TOPO 11 neg. 4/06
Stopped Arimidex 5/06
TCH 5/06, 6 treatments
Herceptin 5/06 - for 1 yr.
9/06 Completed chemo
Started Femara Sept. 2006
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Old 03-12-2008, 10:36 PM   #5
TSund
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test

Jean,

Is this a blood test?

THX!


Terri
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Terri, spouse of Ruth, Dallas/Ft. Worth area
Ruth dx 05/01/07 (age 50) Filipino
multifocal, several tumors .5 -2.5 cm, large area
Breast MRI showed 2 enlarged nodes, not palpable
100%ER+, 95%PR+, HER2+++
6x pre-surgery TCH chemo finished 9/15/7 Dramatic tumor shrinkage
1 year Herceptin till 6/08
MRM 10/11/07, SNB: 0/4 nodes + Path: tumors reduced to only a few "scattered cells"
now 50% ER+, PR- ???
Rads finished 1/16/08
Added Tamoxifen,
Finished Herceptin 05/08
NOW is the time to appreciate life to the fullest.
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Old 03-13-2008, 04:32 AM   #6
tousled1
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This is the test that has successsfully diagnosed my progression - not once but twice. Tumor marker tests have never been reliable for me but my oncologist and I have found that the HER2 test is extremely reliable ata least in my case.
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Kate
Stage IIIC Diagnosed Oct 25, 2005 (age 58)
ER/PR-, HER2+++, grade 3, Ploidy/DNA index: Aneuploid/1.61, S-phase: 24.2%
Neoadjunct chemo: 4 A/C; 4 Taxatore
Bilateral mastectomy June 8, 2006
14 of 26 nodes positive
Herceptin June 22, 2006 - April 20, 2007
Radiation (X35) July 24-September 11, 2006
BRCA1/BRCA2 negative
Stage IV lung mets July 13, 2007 - TCH
Single brain met - August 6, 2007 -CyberKnife
Oct 2007 - clear brain MRI and lung mets shrinking.
March 2008 lung met progression, brain still clear - begin Tykerb/Xeloda/Ixempra
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Old 03-13-2008, 03:12 PM   #7
Chelee
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Jean, I wish that doctor that invented it would send out a "memo" to all the cancer centers telling them this test IS recommended for early stagers too. (I know he won't...I'm joking of course.)

On a serious note I did ask my oncologist about this test back when Kate 1st mentioned how it worked for her when they found her lung mets. I wanted to see if I could talk my onc into a baseline and continue doing it? She said, "No, we don't use that test". Implying to me...not even for stage IV's?

Then when I went up to the City Of Hope to my 2nd opinion onc that I like so well...she too said they don't use the Her2 serum test. That really surprised me. I still believe in the sooner you find mets the better regardless of what some say. Since we are Her2 which is more aggressive I think all tools should be made availble to us if we are comfortable having them done. (Which I one of them.) So your right Jean, most onc's DO discourage them...I've asked both my onc's now, and both said no.

Chelee
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DX: 12-20-05 - Stage IIIA, Her2/Neu, 3+++,Er & Pr weakly positive, 5 of 16 pos nodes.
Rt. MRM on 1-3-06 -- No Rads due to compromised lungs.
Chemo started 2-7-06 -- TCH - - Finished 6-12-06
Finished yr of wkly herceptin 3-19-07
3-15-07 Lt side prophylactic simple mastectomy. -- Ooph 4-05-07
9-21-09 PET/CT "Recurrence" to Rt. axllia, Rt. femur, ilium. Possible Sacrum & liver? Now stage IV.
9-28-09 Loading dose of Herceptin & started Zometa
9-29-09 Power Port Placement
10-24-09 Mass 6.4 x 4.7 cm on Rt. femur head.
11-19-09 RT. Femur surgery - Rod placed
12-7-09 Navelbine added to Herceptin/Zometa.
3-23-10 Ten days of rads to RT femur. Completed.
4-05-10 Quit Navelbine--Herceptin/Zometa alone.
5-4-10 Appt. with Dr. Slamon to see what is next? Waiting on FISH results from femur biopsy.
Results to FISH was unsuccessful--this happens less then 2% of the time.
7-7-10 Recurrence to RT axilla again. Back to UCLA for options.
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Old 03-13-2008, 06:11 PM   #8
TSund
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Does anyone know why dr's aren't using this test? Unfamiliarity, expense, conflicted feelings about usefulness, etc?

Jean do you know if standard insurance is covering it, and do you know the cost of it on a cash basis?

THX

TRS
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Terri, spouse of Ruth, Dallas/Ft. Worth area
Ruth dx 05/01/07 (age 50) Filipino
multifocal, several tumors .5 -2.5 cm, large area
Breast MRI showed 2 enlarged nodes, not palpable
100%ER+, 95%PR+, HER2+++
6x pre-surgery TCH chemo finished 9/15/7 Dramatic tumor shrinkage
1 year Herceptin till 6/08
MRM 10/11/07, SNB: 0/4 nodes + Path: tumors reduced to only a few "scattered cells"
now 50% ER+, PR- ???
Rads finished 1/16/08
Added Tamoxifen,
Finished Herceptin 05/08
NOW is the time to appreciate life to the fullest.
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Old 03-13-2008, 06:26 PM   #9
Jean
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TSund,
Will find out costs...tomorrow and post.
Yes, it is a blood test. I have learned that msot onc. are slow are on the draw with new test, (remeber when the Oncotype DX test came out)?
Sloan, Mt. Sini, and Cornell in New York were not using it since it was ot
"gold seal" this was only back in 2005...now those very hospital are using the test for the last year. Seem that Her 2 Serum test is having the same
reception. Bet ya, in 2 years it will be standard. That is why this site,
and our information is always cutting edge and out in front.

The dr. told me for those of us that are early stagers we should have a base line so we can track our levels. He said every 6 months.

Chelee this may sound strange for major cancer centers but I have learned that even they can be behind cutting edge. Maybe those centers do have a lab to perform the test.

Regards,
Jean
__________________
Stage 1, Grade 1, 3/30/05
Lumpectomy 4/15/05 - 6MM IDC
Node Neg. (Sentinel node)
ER+ 90% / PR-, Her2+++ by FISH
Ki-67 40%
Arimidex 5/05
Radiation 32 trt, 5/30/05
Oncotype DX test 4/17/06, 31% high risk
TOPO 11 neg. 4/06
Stopped Arimidex 5/06
TCH 5/06, 6 treatments
Herceptin 5/06 - for 1 yr.
9/06 Completed chemo
Started Femara Sept. 2006
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Old 03-13-2008, 06:46 PM   #10
TSund
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Jean, Thank-you for this info.

"Gold Seal" are words I've come to dislike. For some oncs it seems the "safe" way out and permission not to be informed on the latest advances. Our 1st Onc last May didn't know anything about TCH and told us we were bonkers for pursuing anything but the "golden standard". (AC + TH) I believe to this day that the path Ruth took was the right one for her and hopefully will diminish the chances of cardiac toxicity.

How can a test hurt? Why would they oppose it>? Baffles my mind. The "gold standard" pre-made flow chart determines all...(rolling my eyes)
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Terri, spouse of Ruth, Dallas/Ft. Worth area
Ruth dx 05/01/07 (age 50) Filipino
multifocal, several tumors .5 -2.5 cm, large area
Breast MRI showed 2 enlarged nodes, not palpable
100%ER+, 95%PR+, HER2+++
6x pre-surgery TCH chemo finished 9/15/7 Dramatic tumor shrinkage
1 year Herceptin till 6/08
MRM 10/11/07, SNB: 0/4 nodes + Path: tumors reduced to only a few "scattered cells"
now 50% ER+, PR- ???
Rads finished 1/16/08
Added Tamoxifen,
Finished Herceptin 05/08
NOW is the time to appreciate life to the fullest.
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Old 03-13-2008, 07:48 PM   #11
Joe
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The serum test is a blood test. The cost is about $300.00 so most insurances do cover it.

Regards
Joe
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