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Old 12-17-2007, 10:00 AM   #1
Lani
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for Jean and others with very small tumors--her2status trumps size

in predicting prognosis:

http://www.mayoclinic.org/news2007-jax/4385.html
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Old 12-17-2007, 10:02 AM   #2
Lani
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poster presentation number

SABCS 2007: ABSTRACT #6024: Prognosis and clinical outcome of patients with node negative ≤1cm breast cancer
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Old 12-17-2007, 10:45 AM   #3
suzan w
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thank you for this info. Very important!!
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Suzan W.
age 54 at diagnosis
5/05 suspicious mammogram-left breast
5/05 biopsy-invasive lobular carcinoma with LCIS,8mm tumor,stage 1 grade 2, ER+ PR+ Her2+++
6/14/05 bilateral mastectomy, node neg. all scans neg.
Oncotype DX-high risk
8/05-10/05 4 rounds A/C
10/05 -10/06 1 yr. herceptin
arimidex-5 years
2/14/08 started daily self administered injections..FORTEO for severe osteoporosis
7/28/09 BRCA 1 negative BRCA2 POSITIVE
8/17/09 prophylactic salpingo-oophorectomy
10/15/10 last FORTEOinjection
RECLAST infusion(ostoeporosis)
6/14/10 5 year cancerversary!
8/2010-18%increase in bone density!
no further treatments
Oncologist says, "Go do the Happy Dance"
I say,"What a long strange trip its been"
'One day at a time'
6-14-2015. 10 YEAR CANCERVERSARY!
7-16 to 9-16. Extensive (and expensive) dental work done to save teeth. Damage from osteoporosis and chemo and long term bisphosphonate use
6-14-16. 11 YEAR CANCERVERSARY!!
7-20-16 Prolia injection for severe osteoporosis
2 days later, massive hive outbreak. This led to an eventual dx of Chronic Ideopathic Urticaria, an auto-immune disease from HELL.
6-14-17 12 YEAR CANCERVERSARY!!
still suffering from CIU. 4 hospitilizations in the past year

as of today, 10-31-17 in remission from CIU and still, CANCER FREE!!!
6-14-18 13 YEAR CANCERVERSARY!! NED!!
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Old 12-17-2007, 03:07 PM   #4
MJo
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I'm glad I was aggressive. The woman in the office next to recently was diagnosed with a small tumor, but larger than mine was. She is Her2neg and ER/PR positive. She showed me her Oncotype score, and I got Onco Envy. Her score was 12; mine was 32. It reminded me again that Her2 is nasty. We will cure it. We will also find a way to destroy all Stage IV cells. I am sure of it.
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IDC, Stage I, Grade 2
Oncotype DX Score 32
Her2++ E+P+, Node Neg.
Lumpectomy 11/04/05 Clear Margins
3 Dose dense AC (Couldn't tolerate 4)
4 Dose dense Taxol & Herc. (Tolerated well)
36 weeks Herceptin (Could not complete one year due to decrease in MUGA score)
2 years of Arimidex, then three years of Femara
Finished Femara May 2011
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Old 12-17-2007, 04:36 PM   #5
harrie
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Very interesting ariticle. Thank you for sharing with us.
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*** MARYANNE *** aka HARRIECANARIE

1993: right side DCIS, lumpectomy, rads
1999: left side DCIS, lumpectomy, rads, tamoxifen

2006:
BRCA 2 positive
Stage I, invasive DCIS (6mm x 5mm)
Grade: intermediate
sentinal node biopsy: neg
HER2/neu amplified 4.7
ER+/PR+
TOPO II neg
Oncotype dx 20
Bilat mastectomy with DIEP flap reconstruction
oophorectomy

2007:
6 cycles TCH (taxotere, carboplatin, herceptin)
finished 1 yr herceptin 05/07
Arimidex, stopped after almost 1 yr
Femara
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Old 12-18-2007, 01:34 AM   #6
Jean
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Just returned from S.A.

It appears that the Dr.'s are STILL unsure how to treat those with small tumors under 1CM....even through Dr. Slamon has said over and over
that anyone with Her2 positive should have Herceptin...and herceptin with Taxol...is best. I attended an evening session called "Second Opinion" Dr. Neil Love was chairing the panel...Dr. C. Hudis from Sloan stated at his hosptial it was still not standard of care to treat with chemo/herceptin
with small tumors. Dr. Hudis believes in lumpectomy, radiaiton, AI/or
tamoxifen. It is mixed between the dr. in this area, due to lack of data. Most dr. want proven data before changing their protectal.

I believe that ALL tests should be available for ALL women - so then
they can make educated and knowledgable decsions regarding their
treatments.

That is another reason to see more than one dr. before making treatment decsions, along with doing your homework.

Jean
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Stage 1, Grade 1, 3/30/05
Lumpectomy 4/15/05 - 6MM IDC
Node Neg. (Sentinel node)
ER+ 90% / PR-, Her2+++ by FISH
Ki-67 40%
Arimidex 5/05
Radiation 32 trt, 5/30/05
Oncotype DX test 4/17/06, 31% high risk
TOPO 11 neg. 4/06
Stopped Arimidex 5/06
TCH 5/06, 6 treatments
Herceptin 5/06 - for 1 yr.
9/06 Completed chemo
Started Femara Sept. 2006

Last edited by Jean; 12-18-2007 at 04:39 PM..
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