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10-05-2007, 12:02 PM
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#1
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Senior Member
Join Date: Feb 2006
Location: Acworth, GA
Posts: 2,104
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Chemo Cancelled Again
Yesterday I went for my chemo treatment (Taxol/Carboplatin/Herceptin) and chemo was cancelled again due to low blood counts. I did get my Herceptin. Seems that even with the Nupogen shots and Arsnsep shots my counts continue to drop. My hemoglobin was 9.2 and my white count was below 1 so therefore no chemo this week. This is the second time this has happened since I started my treatment. First round no problems but the last two rounds the third week my counts have been too low to get the chemo. Has this happend to anyone else? What can I do to get my counts up? I've been getting the injections, doing the standard supplements and eating more protein. Any suggestions from anyone to get my counts up would be appreciated.
Also I'm scheduled for my Brain MRI and chest scan on Monday so I would appreciate your prayers. If he chemo is kicking my blood counts so bad I can only hope that it is also doing it's job on kicking butt on the cancer cells. I'll have the results of my tests October 11th.
__________________
Kate
Stage IIIC Diagnosed Oct 25, 2005 (age 58)
ER/PR-, HER2+++, grade 3, Ploidy/DNA index: Aneuploid/1.61, S-phase: 24.2%
Neoadjunct chemo: 4 A/C; 4 Taxatore
Bilateral mastectomy June 8, 2006
14 of 26 nodes positive
Herceptin June 22, 2006 - April 20, 2007
Radiation (X35) July 24-September 11, 2006
BRCA1/BRCA2 negative
Stage IV lung mets July 13, 2007 - TCH
Single brain met - August 6, 2007 -CyberKnife
Oct 2007 - clear brain MRI and lung mets shrinking.
March 2008 lung met progression, brain still clear - begin Tykerb/Xeloda/Ixempra
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10-05-2007, 12:34 PM
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#2
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Senior Member
Join Date: Mar 2007
Location: CHARLOTTE NC USA
Home town (ECUADOR) South America
Posts: 542
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count on me for the prayers Kate and for the white cell from my simple opinion just relax, rest ...and eat right ....let this question for our other sister ....to answer
__________________
Lily Diag April/06 5 months after give birth my son Max stage IV mets on liver (5 tumors) 38 year old, her2+++ and ER+PR+ from32 nodes 4 positives mastectomy right breast chemo before surgery herceptin/carboplatin/taxotere ,clear and surgery have radiation 20, `& then herceptin and tamoxifen NED until Aug/07 body only then 'n June 04-06-07 .1 lesion of 1.6 cm on cerebellum ...novalis ,open sugery 5m.m brain met again novalis, 4mm.In the liver. Waiting 2 months now 3 tumors enroll on T-MCC trial start first infusion Nov 5/07 at Dec 17 scan show one tumor despair the 2nd and 3th diminish Doc said great results until March/08 ct scan show progression 03-05-08 start tykerb & xeloda
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10-05-2007, 12:54 PM
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#3
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Senior Member
Join Date: Sep 2005
Location: Central Florida
Posts: 503
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Oh I hope you can get those counts back up !! I am visualizing those cancer cells getting their nasty hineys whupped... too bad your little hiney gets whupped too. Hang in there!
Eat right, rest, and think positive. I am sending you sunny vibes from Florida.
Maria
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10-05-2007, 02:45 PM
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#4
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Senior Member
Join Date: Oct 2005
Posts: 3,519
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Hi Kate - Are you getting Neupogen or Neulasta? When I was on TCH, I had to switch to Neulasta when Neupogen stopped doing the trick. And a friend of mine who Aranesp has stopped working for has started getting occasional transfusions and those help her stay on track with her chemo...
Sorry this is happening!
__________________
Brenda
NOV 2012 - 9 yr anniversary
JULY 2012 - 7 yr anniversary stage IV (of 50...)
Nov'03~ dX stage 2B
Dec'03~ Rt side mastectomy, Her2+, ER/PR+, 10 nodes out, one node positive
Jan'04~ Taxotere/Adria/Cytoxan x 6, NED, no Rads, Tamox. 1 year, Arimadex 3 mo., NED 14 mo.
Sept'05~ micro mets lungs/chest nodes/underarm node, Switched to Aromasin, T/C/H x 7, NED 6 months - Herceptin only
Aug'06~ micro mets chest nodes, & bone spot @ C3 neck, Added Taxol to Herceptin
Feb'07~ Genetic testing, BRCA 1&2 neg
Apr'07~ MRI - two 9mm brain mets & 5 punctates, new left chest met, & small increase of bone spot C3 neck, Stopped Aromasin
May'07~ Started Tykerb/Xeloda, no WBR for now
June'07~ MRI - stable brain mets, no new mets, 9mm spots less enhanced, CA15.3 down 45.5 to 9.3 in 10 wks, Ty/Xel working magic!
Aug'07~ MRI - brain mets shrunk half, NO NEW BRAIN METS!!, TMs stable @ 9.2
Oct'07~ PET/CT & MRI show NED
Apr'08~ scans still show NED in the head, small bone spot on right iliac crest (rear pelvic bone)
Sept'08~ MRI shows activity in brain mets, completed 5 fractions/5 consecutive days of IMRT to zap the pesky buggers
Oct'08~ dropped Xeloda, switched to tri-weekly Herceptin in combo with Tykerb, extend to tri-monthly Zometa infusion
Dec'08~ Brain MRI- 4 spots reduced to punctate size, large spot shrunk by 3mm, CT of torso clear/pelvis spot stable
June'09~ new 3-4mm left cerrebellar spot zapped with IMRT targeted rads
Sept'09~ new 6mm & 1 cm spots in pituitary/optic chiasm area. Rx= 25 days of 3D conformal fractionated targeted IMRT to the tumors.
Oct'09~ 25 days of low dose 3D conformal fractionated targeted IMRT to the bone mets spot on rt. iliac crest that have been watching for 2 years. Added daily Aromasin back into treatment regimen.
Apr'10~ Brain MRI clear! But, see new small spot on adrenal gland. Change from Aromasin back to Tamoxifen.
June'10~ Tumor markers (CA15.3) dropped from 37 to 23 after one month on Tamoxifen. Continue to monitor adrenal gland spot. Remain on Tykerb/Herceptin/Tamoxifen.
Nov'10~ Radiate positive mediastinal node that was pressing on recurrent laryngeal nerve, causing paralyzed larynx and a funny voice.
Jan'11~ MRI shows possible activity or perhaps just scar tissue/necrotic increase on 3 previously treated brain spots and a pituitary spot. 5 days of IMRT on 4 spots.
Feb'11~ Enrolled in T-DM1 EAP in Denver, first treatment March 25, 2011.
Mar'11~ Finally started T-DM1 EAP in Denver at Rocky Mountain Cancer Center/Rose on Mar. 25... hallelujah.
"I would rather be anecdotally alive than statistically dead."
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10-05-2007, 02:50 PM
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#5
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Senior Member
Join Date: Sep 2005
Location: Central Coast, CA
Posts: 3,207
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Kate, I'm so sorry you are having to deal with this. My only thought would be, why not do the chemo weekly - it is a lower dose and may be easier on the blood counts.
Beyond that, I'm sure you are doing what you can from a nutritional standpoint (lots of protein, iron, etc.). Are you able to get any exercise? Also, during chemo I got regular "energy work" done - mainly accupressure type stuff but I believe acupuncture may also help.
I'll be thinking about you on monday - I guess it's official scan day as I have one, too. I see it's also columbus day and Thanksgiving (in Canada).
hang in there
Chris
__________________
Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial
5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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10-05-2007, 02:54 PM
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#6
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Senior Member
Join Date: Mar 2007
Location: CHARLOTTE NC USA
Home town (ECUADOR) South America
Posts: 542
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kATE I remenber now that when my white cells was extremy low ...I got transfucion next day ...and that is it ...I took my quemo next day
__________________
Lily Diag April/06 5 months after give birth my son Max stage IV mets on liver (5 tumors) 38 year old, her2+++ and ER+PR+ from32 nodes 4 positives mastectomy right breast chemo before surgery herceptin/carboplatin/taxotere ,clear and surgery have radiation 20, `& then herceptin and tamoxifen NED until Aug/07 body only then 'n June 04-06-07 .1 lesion of 1.6 cm on cerebellum ...novalis ,open sugery 5m.m brain met again novalis, 4mm.In the liver. Waiting 2 months now 3 tumors enroll on T-MCC trial start first infusion Nov 5/07 at Dec 17 scan show one tumor despair the 2nd and 3th diminish Doc said great results until March/08 ct scan show progression 03-05-08 start tykerb & xeloda
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10-05-2007, 03:02 PM
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#7
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Senior Member
Join Date: Jun 2006
Location: San Antonio, TX
Posts: 2,357
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Hi Kate!
I took Neulasta which worked for me, but I haven't had the others. I'll surely be thinking of you on Monday and hoping for super good results for you. I'm getting Herceptin and see the onc that same day. I'll be requesting scans and a brain MRI. I'm praying for you and thinking really good thoughts for ya. ma
__________________
MA in TX.
Grateful for each and every day....
Diag. 12/05 at age 60
Stage II, Grade 3, 4.5 cm primary tumor
ER/PR- Her2 +3 strongly positive
Her2 by FISH 7.7 amplified
vascular invasion
Ki67 20% borderline
Jan - March '06 Taxotere/Adriamycin X 3 to try to shrink tumor - it grew
April '06 Rt Modified Radical Mas, 7 of 9 nodes positive
April - Aug. '06 Herceptin/Taxol/Carboplatin X 8 (dose dense)
Sept - Dec. '06 Navelbine/Herceptin x 8 (dose dense)
Radiation & Herceptin Jan. 22 - March 1, 2007
Finished Herceptin Dec. 10 '08! One extra year.
Port removed August, 2012.
8 1/2 years since diagnosis! 5 1/2 Years NED!
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10-05-2007, 03:27 PM
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#8
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Senior Member
Join Date: Aug 2003
Location: Morris, IL
Posts: 3,507
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Oh Kate
I wish your counts would improve...maybe a blood transfusion will get them back up so they can regenerate quicker...or maybe switching to Neulasta....or Procrit....I wish I could give you some of mine to give you a boost...i am always astonished that all the nosebleeds I have on this that my counts are still good....keeping you in my prayers dear Kate...sending you a big hug and lots of love...think RED!!!!!
__________________
"Be kinder than necessary, for everyone you meet is fighting some kind of battle."
Hugs & Blessings
Sheila
Diagnosed at age 49.99999 2/21/2002 via Mammography (Calcifications)
Core Biopsy 2/22/02
L. Mastectomy 2/25/2002
Stage 1, 0.7cm IDC, Node Neg from 19 nodes Her2+++ ER PR Neg
6/2003 Reconstruction W/ Tissue Expander, Silicone Implant
9/2003 Stage IV with Mets to Supraclavicular nodes
9/2003 Began Herceptin every 3 weeks
3/2006 Xeloda 2500mg/Herceptin for recurrence to neck nodes
3/2007 Added back the Xeloda with Herceptin for continued mets to nodes
5/2007 Taken Off Xeloda, no longer working
6/14/07 Taxol/Herceptin/Avastin
3/26 - 5/28/08 Taxol Holiday Whopeeeeeeeee
5/29 2008 Back on Taxol w Herceptin q 2 weeks
4/2009 Progression on Taxol & Paralyzed L Vocal Cord from Nodes Pressing on Nerve
5/2009 Begin Rx with Navelbine/Herceptin
11/09 Progression on Navelbine
Fought for and started Tykerb/Herceptin...nodes are melting!!!!!
2/2010 Back to Avastin/Herceptin
5/2010 Switched to Metronomic Chemo with Herceptin...Cytoxan and Methotrexate
Pericardial Window Surgery to Drain Pericardial Effusion
7/2010 Back to walking a mile a day...YEAH!!!!
9/2010 Nodes are back with a vengence in neck
Qualified for TDM-1 EAP
10/6/10 Begin my miracle drug, TDM-1
Mixed response, shrinking internal nodes, progression skin mets after 3 treatments
12/6/10 Started Halaven (Eribulen) /Herceptin excellent results in 2 treatments
2/2011 I CELEBRATE my 9 YEAR MARK!!!!!!!!!!!!!
7/5/11 begin Gemzar /Herceptin for node progression
2/8/2012 Gemzar stopped, Continue Herceptin
2/20/2012 Begin Tomo Radiation to Neck Nodes
2/21/2012 I CELEBRATE 10 YEARS
5/12/2012 BeganTaxotere/ Herceptin is my next miracle for new node progression
6/28/12 Stopped Taxotere due to pregression, Started Perjeta/Herceptin
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10-05-2007, 03:59 PM
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#9
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Senior Member
Join Date: Jul 2006
Posts: 869
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Kate, Will be thinking of you with prayers for positive results! Cathy aka Ceesun
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10-05-2007, 04:19 PM
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#10
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Senior Member
Join Date: Feb 2006
Location: Acworth, GA
Posts: 2,104
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To answer some questions that were raised:.
My chemo (Taxol/Carboplatin) is weekly with 3 weeks on 1 week off. I'm on the neupogen shots for 3 days after each chemo and since my chemo is weekly therefore I can't get Neulasta. Since the Arnasep shots don't ssem to be working we now switched to Procrit as of this week.
__________________
Kate
Stage IIIC Diagnosed Oct 25, 2005 (age 58)
ER/PR-, HER2+++, grade 3, Ploidy/DNA index: Aneuploid/1.61, S-phase: 24.2%
Neoadjunct chemo: 4 A/C; 4 Taxatore
Bilateral mastectomy June 8, 2006
14 of 26 nodes positive
Herceptin June 22, 2006 - April 20, 2007
Radiation (X35) July 24-September 11, 2006
BRCA1/BRCA2 negative
Stage IV lung mets July 13, 2007 - TCH
Single brain met - August 6, 2007 -CyberKnife
Oct 2007 - clear brain MRI and lung mets shrinking.
March 2008 lung met progression, brain still clear - begin Tykerb/Xeloda/Ixempra
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10-05-2007, 05:15 PM
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#11
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Senior Member
Join Date: Oct 2006
Location: Louisville KY
Naples FL
Posts: 665
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Prayers are coming your way. The wait on these test is enough to cause
anxiety attacks. I wish they would just sit down and read them immediately. Lots of luck.
patb
__________________
patb
Diagnosed June, 06, Stage I, Grade3, ER+PR- Her2positive, No Nodes. A/C X 4. Radiation 33 with boost, Herceptin every two weeks until Nov.
07, Arimedex for 5 years. Mugas and Echo and chest xRay. Bone scan of whole Body, and Back of Brain and spine MRI.
CT scan of Lungs every six months
due to two small places. December
2009, bone scan due to bone pain.
Follow up test in 2010.
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10-05-2007, 05:42 PM
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#12
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Senior Member
Join Date: Sep 2005
Posts: 556
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Lukine
Hi Kate,
Have you asked for Lukine shots, they are like Neupogen given everyday.
I am pretty sure that your scans are going to be good. Wishing you all the best.
Julie
__________________
Diagnosed in Sept 2004 while pregnant with the second child. Stage 3b, tumor 4.5cm, 4 auxillary and supraclav node positive. Her2+++ FISH 9.4 and er-,pr-.
Had dose dense neoadjuvant AC,Taxol then mastectomy,radiation+xeloda+Herceptin.
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10-05-2007, 05:43 PM
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#13
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Senior Member
Join Date: Aug 2006
Location: Sheboygan, WI
Posts: 2,582
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Hi Kate,
No idea where my first post went to you but here goes again. I drowned myself with water when I was going through chemo. I drank and drank and drank the days after chemo. I also received a Neulasta shot. I always would envision all the water as a way of flushing the crap out of my body. Not sure if it helped or not BUT my counts never dropped off.
Prayers are with you Kate. I'm sorry the numbers are down.
God's Peace,
Mary Jo
__________________
"Be still and know that I am God." Psalm 46:10
Dx. 6/24/05 age 45 Right Breast IDC ER/PR. Neg., - Her2+++ RB Mast. - 7/28/05 - 4 cm. tumor Margins clear - 1 microscopic cell 1 sent. node No Vasucular Invasion 4 DD A/C - 4 DD Taxol & Herceptin 1 full year of Herceptin received every 3 weeks 28 rads prophylactic Mast. 3/2/06
17 Years NED
<>< Romans 8:28
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10-05-2007, 06:00 PM
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#14
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Senior Member
Join Date: Aug 2006
Location: Franklin, MA
Posts: 131
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Kate,
I am currently on Navelbine and Herceptin (Navelbine is 3 weeks on/1 week off) and the Herceptin is once every 3 weeks. The Herceptin does not impact my counts, but the Navelbine does. I normally get 3 Neupogen shots after each of the 1st 2 weeks of Navelbine and after the 3rd week (going into the 1 week off), I get the stronger Neulasta shot. This has seemed to work well for me.
Good luck with your upcoming scans.
__________________
Diagnosed 10-03-2005 (34 wks pregnant, 38 yrs old)
Lumpectomy Nov-2005. 10/18 Lymph Nodes impacted
Mets to liver, spine & femurs (thus being stage IV right from the get-go)
ER-, PR-, HER2+
Taxol/Herceptin/Zometa started Dec-2005. 11 cycles of Taxol.
Sept-2006: PET/CT scan of mets to liver, spine and femurs - Stable. Activity in R breast & mediastinum (not seen in prior scans).
Navelbine (3 wks on/1 wk off) as of Oct--2006 & continued Herceptin (every 3 wks) & Zometa (every 6 wks)
Jan-2007: PET/CT Scan - Stable. Continued Nav. through March-2007, then Herc./Zom. only after that.
June-2007: PET/CT Scan - activity in mediastinum. Back on Navelbine as of July-2007.
Scanned Quarterly since Oct-2007 - a few small scares, but otherwise stable due to continuing weekly Navelbine, Herceptin and Quarterly Zometa.
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10-05-2007, 06:08 PM
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#15
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Senior Member
Join Date: Sep 2005
Location: Mountains of Virginia
Posts: 2,267
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Kate,
I'm so sorry to hear that you are going thru this again. Would adding liver/beets other high iron foods help any? Just a thought, you've probably got the diet thing down pat.
Keeping you in my thoughts and prayers. Sending you strength and courage.
__________________
Rhonda (Sassy)
dx age 45
DX 2/15/05 Stage IIb (at surgery)restaged IIIa
Left mast .9cm tumor 5 of 14 nodes
Triple Positive
4 DD A/C
12 Taxol/Herceptin
33Rads
Strange infect mast site one year aft surg, hosp 1 wk
Herceptin for total of 18 months
Lupron Monthly 4 yrs
Neurontin for aches, pains and hot flashes(It works!)
Ovaries removed 11/09 stop Lupron and Neurontin
Arimidex 6 yrs (tried Femara, no SE improvement)
Tried Exemestane-hips got so bad could hardly walk
Back to Arimidex for year seven
Zometa 2X Annual for 7years, Lasix
Stop Arimidex 5/13
Stop Zometa 7/13-Bi-lateral Stress Fractures in Femurs from Zometa
5/14 Start Tamoxifen
3/15 Stem cell transplant to stimulate femur bone growth/healing
5/15 Complete fracture of right femur/Titanium rods both femurs
9/16 Start Evista stopTamoxifen
3/17 Stop Evista--unwelcome side effects!
NED and no meds.......
14 YEARS NED!
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10-05-2007, 06:55 PM
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#16
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Senior Member
Join Date: Sep 2006
Location: Houston, Texas
Posts: 624
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I am sorry that you had to have your chemo cancelled and I hope you are feeling better soon. I had my chemo cancelled today, also, but because my oncologist thinks that I am dehydrated. She gave me a big bag of fluids instead. I will give more details in another post, but I hope your counts get back up soon and I will keep you in my prayers. Best wishes on Monday!
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10-05-2007, 08:13 PM
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#17
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Senior Member
Join Date: Jan 2007
Location: Thornhill, Ontario
Canada
Posts: 2,320
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Kate,
Sorry to hear this. I hope your blood counts go up ASAP. Hopefully the Procrit will do the trick and your counts will be back up pronto.
all the best
caya
__________________
ER90%+/PR 50%+/HER 2+
1.7 cm and 1.0 cm.
Stage 1, grade 2, Node Negative (16 nodes tested)
MRM Dec.18/06
3 x FEC, 3 x Taxotere
Herceptin - every 3 weeks for a year, finished May 8/08
Tamoxifen - 2 1/2 years
Femara - Jan. 1, 2010 - July 18, 2012
BRCA1/BRCA2 Negative
Dignosed 10/16/06, age 48 , premenopausal
Mild lymphedema diagnosed June 2009 - breast surgeon and lymph. therapist think it's completely reversible - hope so.
Reclast infusion January 2012
Oopherectomy October 2013
15 Years NED!!
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10-05-2007, 09:12 PM
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#18
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Member
Join Date: Jan 2007
Location: San Clemente, California
Posts: 14
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remedy for low white count
Hi Kate,
Several times my counts dropped low like yours during chemo. I got Neulasta shots. Also, my husband would bake a whole chicken, take the meat off the bones, crack the bones and boil them to make a broth for soup. It sounds wierd. My naturopath told us to do that. I was able to take all my chemo on schedule and ate a lot of good soup!
I will pray for you.
Connie
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10-05-2007, 09:22 PM
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#19
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Senior Member
Join Date: Dec 2006
Location: Oregon
Posts: 715
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Kate,
Wish I could help, but will be praying for better counts and chemo soon.
My experience is only with AC and then after that 4 weeks Taxol. I do remember getting the Neulasta and the Procrit. I like the chicken soup routine. Let's get her husband's phone number. My husband was a good cook while I was on chemo, not sure he would go so far as to make homemade soup tho. Try all the tricks you can and we will pray all we can.
Friends of yours and friends of Tiptoe's,(Couldn't resist mentioning our little mascot)
Hugs to you, Catherine
__________________
Catherine
Found my own lump in the shower
April 2006 at the age of 58
Stage IIB, ER- PR- HER2+++ multi focal tumors, largest 2.3cm
Chemo first: AC/Taxol over 16 weeks
Bilateral mastectomy Sep 06
33 rads after the surgery
1 year of Herceptin completed Dec 07
15 years and no recurrence as of April 2021
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10-05-2007, 10:41 PM
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#20
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Senior Member
Join Date: Oct 2005
Location: New Jersey
Posts: 3,154
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Hi Kate,
I was on the TCH but it was every 3 weeks. Therefor I had the Nuelasta
shots which kept my count going. Make sure you are getting enough
rest - east smaller meals more often. Good quality snacks, like yogurt
and whole grains.
Wishing you all the best !
Jean
__________________
Stage 1, Grade 1, 3/30/05
Lumpectomy 4/15/05 - 6MM IDC
Node Neg. (Sentinel node)
ER+ 90% / PR-, Her2+++ by FISH
Ki-67 40%
Arimidex 5/05
Radiation 32 trt, 5/30/05
Oncotype DX test 4/17/06, 31% high risk
TOPO 11 neg. 4/06
Stopped Arimidex 5/06
TCH 5/06, 6 treatments
Herceptin 5/06 - for 1 yr.
9/06 Completed chemo
Started Femara Sept. 2006
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