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Old 06-12-2007, 03:37 PM   #1
Sheila
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Another Change For Me

Well just like the insurance company to call the shots on chemo....my insurance company WOULD NOT approve Abraxane...just Taxol, so I will be getting Taxol Avastin with the Herceptin.....guess I need to get a wig after all. Start popping Decadron...my first treatment is Thursday for 5 hours for the 2. Wish me luck.
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is fighting some kind of battle."



Hugs & Blessings
Sheila
Diagnosed at age 49.99999 2/21/2002 via Mammography (Calcifications)
Core Biopsy 2/22/02
L. Mastectomy 2/25/2002
Stage 1, 0.7cm IDC, Node Neg from 19 nodes Her2+++ ER PR Neg
6/2003 Reconstruction W/ Tissue Expander, Silicone Implant
9/2003 Stage IV with Mets to Supraclavicular nodes
9/2003 Began Herceptin every 3 weeks
3/2006 Xeloda 2500mg/Herceptin for recurrence to neck nodes
3/2007 Added back the Xeloda with Herceptin for continued mets to nodes
5/2007 Taken Off Xeloda, no longer working
6/14/07 Taxol/Herceptin/Avastin
3/26 - 5/28/08 Taxol Holiday Whopeeeeeeeee
5/29 2008 Back on Taxol w Herceptin q 2 weeks
4/2009 Progression on Taxol & Paralyzed L Vocal Cord from Nodes Pressing on Nerve
5/2009 Begin Rx with Navelbine/Herceptin
11/09 Progression on Navelbine
Fought for and started Tykerb/Herceptin...nodes are melting!!!!!
2/2010 Back to Avastin/Herceptin
5/2010 Switched to Metronomic Chemo with Herceptin...Cytoxan and Methotrexate
Pericardial Window Surgery to Drain Pericardial Effusion
7/2010 Back to walking a mile a day...YEAH!!!!
9/2010 Nodes are back with a vengence in neck
Qualified for TDM-1 EAP
10/6/10 Begin my miracle drug, TDM-1
Mixed response, shrinking internal nodes, progression skin mets after 3 treatments
12/6/10 Started Halaven (Eribulen) /Herceptin excellent results in 2 treatments
2/2011 I CELEBRATE my 9 YEAR MARK!!!!!!!!!!!!!
7/5/11 begin Gemzar /Herceptin for node progression
2/8/2012 Gemzar stopped, Continue Herceptin
2/20/2012 Begin Tomo Radiation to Neck Nodes
2/21/2012 I CELEBRATE 10 YEARS
5/12/2012 BeganTaxotere/ Herceptin is my next miracle for new node progression
6/28/12 Stopped Taxotere due to pregression, Started Perjeta/Herceptin
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Old 06-12-2007, 03:57 PM   #2
Mary Anne in TX
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Oh Sheila, isn't it just like an insurance company to think they know best!

Well, maybe the rats are right and it's the nasty ol' Taxol that is needed to kill those cancer cells. That's what I'll be believing and praying for you. Is it time for new hair?

Here's to Thursday's treatment being a good adventure for you. May those dasterdly little cells beware. Lots of love to you, ma
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Grateful for each and every day....

Diag. 12/05 at age 60
Stage II, Grade 3, 4.5 cm primary tumor
ER/PR- Her2 +3 strongly positive
Her2 by FISH 7.7 amplified
vascular invasion
Ki67 20% borderline
Jan - March '06 Taxotere/Adriamycin X 3 to try to shrink tumor - it grew
April '06 Rt Modified Radical Mas, 7 of 9 nodes positive
April - Aug. '06 Herceptin/Taxol/Carboplatin X 8 (dose dense)
Sept - Dec. '06 Navelbine/Herceptin x 8 (dose dense)
Radiation & Herceptin Jan. 22 - March 1, 2007
Finished Herceptin Dec. 10 '08! One extra year.
Port removed August, 2012.
8 1/2 years since diagnosis! 5 1/2 Years NED!
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Old 06-12-2007, 04:02 PM   #3
chrisy
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Well POOH! Any chance you can appeal this decision? I know you want/need to get started on treatment but the lower toxicity of Abraxane would certainly be welcome. We get very spoiled - as we should - by being able to live relatively free from side effects (at least compared to the sordid history and reputation of chemotherapy). Keeping you strong for the battle is so important.

However, I can see that you are ready to take on the fight, and you know that Taxol will do the job. I certainly wish you well, sister!
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June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial

5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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Old 06-12-2007, 04:12 PM   #4
doh2pa
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Hi Sheila,

Well, I'd like to think you were meant to get Taxol instead of Abraxane for this battle. I will keep a good thought, say a prayer, wish you luck and love and I know you will do well. You are an inspiration to us all. Keep us all posted.

Donna
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Diagnosed 2/04 - Invasive ductal - no clean margins
node negative - er+pr+, her2++
Mastectomy 4/04 - 4 rounds AC
9/05 - mets to liver treated with carbo/ixabipelone/herceptin
3/06 - complete remission
9/06 - new liver mets, starting Taxotere/Herceptin
1/07 -Liver mets stable, staying on Herceptin
5/07 - Liver, lung progression - starting T/X
12/07 - Liver, lung progression - starting weekly Navilbene/Herceptin
4/08 - Liver progression - started Abraxane, Carbo, Tykerb and Herceptin
7/08 - Liver Progression - started Gemzar, Avastin and Tykerb
10/08 - Liver progression - starting Doxil
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Old 06-12-2007, 04:58 PM   #5
Patb
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Best of luck to you with your treatment. Don't we just love insurance companies.

patb
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Diagnosed June, 06, Stage I, Grade3, ER+PR- Her2positive, No Nodes. A/C X 4. Radiation 33 with boost, Herceptin every two weeks until Nov.
07, Arimedex for 5 years. Mugas and Echo and chest xRay. Bone scan of whole Body, and Back of Brain and spine MRI.
CT scan of Lungs every six months
due to two small places. December
2009, bone scan due to bone pain.
Follow up test in 2010.
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Old 06-12-2007, 05:12 PM   #6
jones7676
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Good Luck

Darn insurance companies.....I believe this will work for you, it is in the same family. Think of how nice and "cool" your head will be.
Good Luck
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Old 06-12-2007, 05:17 PM   #7
Margerie
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Sheila,

It is such a shame the insurance companies can dictate treatment!! I remembered the taxol was realtively inexpensive, but abraxane isn't unfortunately.

http://uuhsc.utah.edu/pharmacy/bulletins/abraxane.html

I hope your triple combo does the trick!
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Are we there yet?


Dx 10/05 IDC, multi-focal, triple +, 5 nodes+
MRM, 4 DD A/C, 12 weekly taxol + herceptin
rads concurrent with taxol/herceptin
finished herceptin 01/08
ooph, Arimidex, bilateral DIEP reconstruction
NED
Univ. of WA, Seattle vaccine trial '07
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Old 06-12-2007, 05:17 PM   #8
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Well, I'm thinking it will be fine, so don't lose any sleep over it...btw, my hair is really, really thinning on Abraxane/Tykerb and I'm not sure which one is the culprit. Maybe both! Anyway, best wishes for Thursday, I know you can and will rise to the challenge!

<3 Lolly
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Sept.'99 - Dx.Stage IIIB, IDC ER/PR-, HER2+++ by IHC, confirmed '04 by FISH. Left MRM, AC x's 4, Taxol x's 4, 33 Rads, finishing Tx May 2000. Jan.'01 - local/regional recurrence, Stage IV. Herceptin/Navelbine weekly till NED August 2001, then maintenance Herceptin. Right Mast. April 2002. Local/Regional recurrence April '04, Herceptin plus/minus chemo until May '07. Gemzar added from Feb.'07-April '07; Tykerb/Abraxane until August '07, back on Herceptin plus Taxotere and Xeloda Sept. '07. Stopped T/X Nov. '07, stopped Herceptin Dec. '07, started Avastin/Taxol/Carboplatin Dec. '07. Progression in chest skin, stopped TAC March '03, started radiation.

Herceptin has served as the "Backbone" of my treatment strategy for over 6 years, giving me great quality of life. In 2005, I was privileged to participate in the University of Washington/Seattle HER2 Vaccine Trial.
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Old 06-12-2007, 05:33 PM   #9
DonnaD
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Dear Sheila,
I have faith in your onc that this treatment is just as good. I only wish my treatment was the same day so we could keep each other company.

Got a great place to look at wigs, it is in Willowbrook. The gal that helped me had treatment at the same place we are several years ago.

You are in my prayers daily, I'll say an extra special one for you dear friend on Thursday.
Love,
Donna
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Crystal Lake, IL
Diagnosed 8/4/06 at age 54
Lumpectomy 8/30/06
Stage llA, grade 3, ER/PR-, Her2++
1.7 cm tumor, 1+ lymph node out of 9
Completed 4 A/C, & 4 Taxol with Herceptin
36 rads completed 5/16/07
Mammograms, 7/07 clear
fractured ribs in radiated area 10/07
Finished Herceptin 12/27/07
Mammogram,CT,tumor markers 1/08 - small lung nodules in radiated area, repeated tests 3/08 stable
Mammogram,CT ,tumor markers 6/08 stable
NED 2 years!!
3 years !!!
4years!!!!
4 years, 10 months and 8 day NED, calling it 5 years!!!
Official 5 years 8/30/2011
8/31/ 2012 - 6 years!!!!!!
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Old 06-12-2007, 05:53 PM   #10
Chelee
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Shelia, I'm sorry to hear your insurance company stuck their nose where it doesn't belong. Its not right, yet it happens far to often! As mentioned by someone else...is there anyway you can appeal this or would it take too long? I know with my insurance company they have an expedited appeal if its needed asap. (They have 72 hrs if its expedited.) Either way...sending you positive thoughts & wishing nothing but the best for you.

Chelee
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DX: 12-20-05 - Stage IIIA, Her2/Neu, 3+++,Er & Pr weakly positive, 5 of 16 pos nodes.
Rt. MRM on 1-3-06 -- No Rads due to compromised lungs.
Chemo started 2-7-06 -- TCH - - Finished 6-12-06
Finished yr of wkly herceptin 3-19-07
3-15-07 Lt side prophylactic simple mastectomy. -- Ooph 4-05-07
9-21-09 PET/CT "Recurrence" to Rt. axllia, Rt. femur, ilium. Possible Sacrum & liver? Now stage IV.
9-28-09 Loading dose of Herceptin & started Zometa
9-29-09 Power Port Placement
10-24-09 Mass 6.4 x 4.7 cm on Rt. femur head.
11-19-09 RT. Femur surgery - Rod placed
12-7-09 Navelbine added to Herceptin/Zometa.
3-23-10 Ten days of rads to RT femur. Completed.
4-05-10 Quit Navelbine--Herceptin/Zometa alone.
5-4-10 Appt. with Dr. Slamon to see what is next? Waiting on FISH results from femur biopsy.
Results to FISH was unsuccessful--this happens less then 2% of the time.
7-7-10 Recurrence to RT axilla again. Back to UCLA for options.
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Old 06-12-2007, 06:05 PM   #11
rinaina
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Saying prayers for you and hoping you have an easy time with the treatments. Best of luck with this new approach.
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Dx:3/06 had a lumpectomy April 19, 2006
Her2+ er/pr- Stage I Grade 3 tumor size 1.4 cm, node negative
AC 4 dense doses
34 radiation treatments including booster doses
receiving herceptin every 3 weeks since late August 2006 for 12 months
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Old 06-12-2007, 06:12 PM   #12
Mary Jo
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Hi Sheila,

Sending prayers that the Lord would protect your body from the nasty effects of chemo but He would allow the chemo to do it's job.

I'll keep you in my daily prayers Sheila.

Love & hugs,

Mary Jo
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Dx. 6/24/05 age 45 Right Breast IDC
ER/PR. Neg., - Her2+++
RB Mast. - 7/28/05 - 4 cm. tumor
Margins clear - 1 microscopic cell 1 sent. node
No Vasucular Invasion
4 DD A/C - 4 DD Taxol & Herceptin
1 full year of Herceptin received every 3 weeks
28 rads
prophylactic Mast. 3/2/06

17 Years NED

<>< Romans 8:28
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Old 06-12-2007, 06:43 PM   #13
Adriana Mangus
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Thumbs up Thinking of you

Dear Sheila: I have heard good things about Avastin in combination with Herceptin, guess if my current combo does not work that will be my next stop

I will be thinking of you this Thursday, hang in there sister, you can do it.

Sending you positive vibes and a BIG HUG.
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1994 - rt brst, .lump, underarm node dissection,chemo+rad 1.2 cms, Grade 3.
28 nodes neg
Er,Pr, Positive HER2 status unknown
2003- Recur to rt lung.July 16 ( B-Day!)
Her2+++ Er,Pr, Negative
2003 - Aug04--Navelbine + Herceptin
2004- 2007--
NED - Herceptin, only
2007 Feb-April Xeloda added to hereceptin
2007-May Back on Navelbine+Herceptin
2008-Feb-Mar 15 Ses Rad to Rt. Lung
2008- Oc 17 Add Tykerb to Herceptin
2009- June-- Discont Tykerb
2009 July 7--Current Taxol + Herceptin
2009 Dec--Discontinued treatment due to progression. Looking into cyberknife.
2010-Aug Accepted to TDM1, no SE, except liver count went up.
2010-2011 September got kicked out of the trial, due to a small spot found on lung.
2011- 2012 September thru early 2013 on Herceptin
2013- March Bone density shows small spot on 5th rib.
2013 - April 4th appt with onc. will post after discussing course of treatment.
2013-March-April Cyber knife to brain and radiation to rib. Chest --base line before chemo-CT-Scan stable for lung issue. CA2729 Normal.
2013 April Herceptin- TDMI
2013 Sept Herceptin + Perjeta . CA2729 within normal range. Brain and Pet scans October 31st. will post results.
2013 October Brain MRI- mixed response. Will see Onc/rad on Halloween.
2013 October/November Brain-MRI nothing new. Repeat MRI next year in May.

2013 December Continue Herceptin and Perjeta. Stable at the moment.
2014 February Brain MRI -clear!
2014 January Added Taxotere to Perjeta+Herceptin.
2014 March Stopped chemo-chest ct-scan next.

2014- March Scans shows tumor's larger, CA2729 higher. Discontinue Herceptin.
2014 April Perjeta+ Halaven
2014 April CA2729 went down 60 points after one cycle. Cough does not want to go away.
2014 June Continue on Perjeta + Halaven-- no more cough. Stable
2014 June Back on Herceptin + abraxane
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Old 06-12-2007, 06:56 PM   #14
Jen
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It's sad that the treatment you receive is dictated by what your insurance will allow rather than what the doctor thinks is best. We need serious healthcare reform in this country and we need it NOW.
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Old 06-12-2007, 07:14 PM   #15
tousled1
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Sheila,

Sorry that your insurance would not approve Abraxane. I'm hoping that the combo with Taxol will be the ticket. At least the insurance company didn't say you had to take Taxatore -- that's the worst! Good luck.
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Stage IIIC Diagnosed Oct 25, 2005 (age 58)
ER/PR-, HER2+++, grade 3, Ploidy/DNA index: Aneuploid/1.61, S-phase: 24.2%
Neoadjunct chemo: 4 A/C; 4 Taxatore
Bilateral mastectomy June 8, 2006
14 of 26 nodes positive
Herceptin June 22, 2006 - April 20, 2007
Radiation (X35) July 24-September 11, 2006
BRCA1/BRCA2 negative
Stage IV lung mets July 13, 2007 - TCH
Single brain met - August 6, 2007 -CyberKnife
Oct 2007 - clear brain MRI and lung mets shrinking.
March 2008 lung met progression, brain still clear - begin Tykerb/Xeloda/Ixempra
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Old 06-12-2007, 08:36 PM   #16
sassy
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Sheila,

Wishing you the best as you start this treatment.
________
GLASS WEED PIPE

Last edited by sassy; 08-22-2011 at 09:17 AM..
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Old 06-12-2007, 09:07 PM   #17
Lala
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Shelia

I remember hearing my oncologist telling me how the insurance company may not pay for my abraxane. His thoughts were we will deal with it after we start you on abraxane. I recall he was prepared to write the insurance company on my behalf to fight for the drug using the current data showing it was necessary. I ended up taking abraxane carboplatin herceptin. My insurance did cover it in the end.

I am sorry you did not get the abraxane as you wanted but the addition of avastin is a good thing. I used avastin and herceptin with no chemo for 6 months and it shrank a few tumors. The combination of avastin and chemo has been proven to do very well for many.

I wish you the best good luck to you.
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DX Fall05 Stage 4 er+ pr+ her2+ liver and bone mets
DX Fall06 Brain mets, Brain mets gone Spring 2007
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Old 06-13-2007, 06:31 AM   #18
RobinP
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I wish you all the blessings in the world with your new treatment. Keep your chin up...praying for you.
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2002- dx her2 positive DCIS/bc TX Mast, herceptin chemo
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Old 06-13-2007, 07:14 AM   #19
MJo
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I agree with LaLa. Avastin is a good drug. It's doing amazing things for two people in my support group - one with stage 4 bc and one with pancreatic cancer. THe guy with PC was in hospice six months ago and he just came back from a vacation in the blue ridge mountains. He's wondering whether to leave hospice now. Hospice sure has changed. It's no longer one way only. Some people go in and out of hospice now. Amazing.
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IDC, Stage I, Grade 2
Oncotype DX Score 32
Her2++ E+P+, Node Neg.
Lumpectomy 11/04/05 Clear Margins
3 Dose dense AC (Couldn't tolerate 4)
4 Dose dense Taxol & Herc. (Tolerated well)
36 weeks Herceptin (Could not complete one year due to decrease in MUGA score)
2 years of Arimidex, then three years of Femara
Finished Femara May 2011
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Old 06-13-2007, 09:04 AM   #20
Hopeful
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Sheila,

I urge you to file an appeal with your insurance company. The efficacy of Abraxane, aka nab-paclitaxel, is far superior to Taxol. Here is a link to an abstract of an article published a year ago on the matter: http://www.ingentaconnect.com/conten...00008/art00006.

Here is an excerpt from that abstract:

"nab-Paclitaxel utilises the natural properties of albumin to reversibly bind paclitaxel, transport it across the endothelial cell and concentrate it in areas of tumour. The proposed mechanism of drug delivery involves, in part, glycoprotein 60-mediated endothelial cell transcytosis of paclitaxel-bound albumin and accumulation in the area of tumour by albumin binding to SPARC (secreted protein, acidic and rich in cysteine). Clinical studies have shown that nab-paclitaxel is significantly more effective than paclitaxel formulated as Cremophor<SUP>®</SUP> EL (CrEL, Taxol<SUP>®</SUP>, CrEL-paclitaxel), with almost double the response rate, increased time to disease progression and increased survival in second-line patients. "


Here is a link to a download of Breast Cancer Update, vol. 2 2007, containing an interview with Frankie Ann Holmes, MD, Co-Director of Breast Oncology Research at Texas Oncology and US Oncology Breast Cancer Research in Houston, TX, discussing the use of Abraxane specifically at page 13: http://www.breastcancerupdate.com/bcu2007/2/default.asp

Wishing you all the best of luck with your treatment plan,

Hopeful
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