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Old 04-16-2007, 07:20 PM   #1
ggweber_2000
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Join Date: Mar 2006
Posts: 8
Unhappy Heart problems with Taxotere?

I did not receive the Herceptin because of being on the control arm of a clinical study. I did receive Taxotere and had a really bad reaction to it. I started having shortness of breath with exertion starting about November 2006, different than my asthma. I transferred to MD Anderson in Houston TX from California because my husband and I travel fulltime in a RV and my insurance is out of TX. I didn't want to take a chance on losing it. My oncologist here sent me to an Internist that specializes in cancer patients and chemo drugs. He sent me for an echo stress test. The cardiologist came into the room and said we have a problem. Long story short. I have blockages in my right coronary artery and left circumflex. They said it could have been caused by the Taxotere. I feel so lucky to be here in TX. My internist and cardiologist both specialzes in cancer patients. All our kids and grandkids are back in WI. I couldn't transfer there because of insurance issues. I had my cancer treatments in CA becasue it was winter when I underwent therapy. WI is way to cold to live in a motorhome during the winter. I will have to have an angioplasty with possible stents. Depending on the results it could be bypass. Anyone else have problems with Taxotere? Thanks for listening to me vent.
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Diagnosed 10/2003 Found lump myself 1 week after having had a 6 month followup mammogram for biopsy on left breast. Nothing abnormal on mammo.
Grade III 2.2cm
Stage 2 Invasive ductal carcinoma Right breast
Grade III 2.2 cm
No lymph node involvement
ER+ PR-
HER2+++

Lumpectomy 11/03
Clinical study BCIRG006 Control Arm no Herceptin
A/C x4
Taxotere X4
Rads x36
Arimidex
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Old 04-16-2007, 11:48 PM   #2
Chelee
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Join Date: Feb 2006
Location: Southern, CA
Posts: 2,511
ggweber_2000, I am so sorry to hear about your heart problems. But thank goodness they found them before anymore damage was done. At least your in very safe hands at MD Anderson. As far as Taxotere...I was on that. I did "TCH"...six rounds. I had ECHO's every 3 months and knock on wood so far all is fine. I'm glad you have some of the best doctors. Hang in there and I will keep you in my prayers.

Chelee
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DX: 12-20-05 - Stage IIIA, Her2/Neu, 3+++,Er & Pr weakly positive, 5 of 16 pos nodes.
Rt. MRM on 1-3-06 -- No Rads due to compromised lungs.
Chemo started 2-7-06 -- TCH - - Finished 6-12-06
Finished yr of wkly herceptin 3-19-07
3-15-07 Lt side prophylactic simple mastectomy. -- Ooph 4-05-07
9-21-09 PET/CT "Recurrence" to Rt. axllia, Rt. femur, ilium. Possible Sacrum & liver? Now stage IV.
9-28-09 Loading dose of Herceptin & started Zometa
9-29-09 Power Port Placement
10-24-09 Mass 6.4 x 4.7 cm on Rt. femur head.
11-19-09 RT. Femur surgery - Rod placed
12-7-09 Navelbine added to Herceptin/Zometa.
3-23-10 Ten days of rads to RT femur. Completed.
4-05-10 Quit Navelbine--Herceptin/Zometa alone.
5-4-10 Appt. with Dr. Slamon to see what is next? Waiting on FISH results from femur biopsy.
Results to FISH was unsuccessful--this happens less then 2% of the time.
7-7-10 Recurrence to RT axilla again. Back to UCLA for options.
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Old 04-17-2007, 05:28 AM   #3
janet11
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Join Date: Aug 2006
Location: Rowlett, TX
Posts: 138
I also had 6 cycles of TCH with no problems. The MUGA scans every three months are for the Herceptin, not the Taxotere. I haven't heard of heart problems with Taxotere at all. Must be a pretty rare side effect. Good luck with treatment!
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Janet in Rowlett Texas

Dx July 2006 IDC 1.8cm, ER-/PR- HER2+ (FISH 7), KI67 High (60%) grade 3, TOPO II neg
Aug2006: lumpectomy, SNB (4 nodes neg), Stage 1
Jan 2007:
Finished 6 cycles of TCH (Taxotere, Carboplatin, Her ceptin). Then Herceptin every 3 weeks.
Feb 2007: Completed Radiation
May 2007: Stopped Herceptin due to low LVEF (49%)
July 2007: LVEF now 44% -- starting Coreg
May 2008: Heart NORMAL! Yippee.
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