A bit of good news (for just this one patient)

[Nguyen]

Hoping that I'm not jinxing my wife for posting this. To be sure, I'll write this again, knock on wood, hoping that I'm not jinxing my wife for posting this. Anyway, her latest CT and CA27.29 results show lung nodules are stabilizing. I was worried sick since the previous two tumour markers were rising consecutively. Knock on wood again, this year will be her 10th years (7 with mets) with this disease.

Just for informational (if you happen to have similar treatment history and tumour profile) purpose, below is what I would have asked for one of the below treatment if the current one fails. We added Herceptin to Femara in the current treatment. Her heart's ejection fraction was 72% at the start, it's now at 62%, so we probably could continue with Herceptin for the rest of this year. Her estradiol is still measureable at 9 pg/ml while being treated with Femara, so if the current treatment fails, I would lean toward Fulvestrant then Fulvestrant and Femara.

Here's a short summary for the next possible treatment as "match-up" with her treatment history:

Endocrine:
- Fulvestrant
- Fulvestrant and AI. There're data indicating the combination work better than either alone.
- Exemestane and Celecoxib

Biologic:
- Herceptin and Avastin
- Herceptin and Tykerb

Endocrine and Biologic in combination:
- temsirolimus (or everolimus) with Femara
- Herceptin and Tykerb and AI (mcf7 xenographt model all tumours went away)
Chemotherapy: Hopefully we won't need this for quite a while.

Nguyen

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Linda's treatment history:

01/2005 - current: Herceptin and Femara
07/2004: It returned again via several small nodules in the lung
10/2002: NED (via CT and CA27.29)!
10/2001 - 01/2005: Femara, (Fosamax)
12/2000 - 10/2001: Herceptin and Navelbine
12/2000: lung metastatic was diagnosed (a few small nodules)
02/1998 - 12/2000: Daily Tamoxifen
05/1997 - 04/1998: Modified Radical Mastectomy, many many cycles of chemo regiments (CAF,Taxol, Carpoplatin, Thiotepa, Navelbine, Taxotere), including HDC, and radiation
05/1997: First diagnosed with BC stage 3A, ER+, PR+, HER2 +, poorly differetiated, nuclear grade 3.