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12-18-2006, 08:55 PM
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#1
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Senior Member
Join Date: Dec 2005
Posts: 274
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Was HER2+ always around
Hi all HER2 family,
I know this sounds silly, but does anyone know if HER2+ breast cancer was around years ago or if it has become some kind of mutated cancer. I have several (acquaintances) not fellow bc friends, who have been indicating to me that this is something new. If I am correct they did not start testing for this until about 10 years ago and that may answer my own question. I guess if they didn't test they wouldn't know but they are insisting this is something that has evolved into a new type of cancer. None of these people are trained in medicine or science and neither am I. Just wondering if anyone has any data on this. Any insight would be greatly appreciated.
Sincerely,
Liz J.
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12-18-2006, 11:08 PM
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#2
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Webmaster
Join Date: Feb 2005
Location: Home of the "Flying Tomato"
Carlsbad, CA
Posts: 2,036
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Liz,
The HER2/neu gene has always been around, but not discovered until the late 80's.
An excellent resource is "HER2 - The Making of Herceptin" by Robert Bezell. It is available on Amazon for less than $5.00.
Warmest Regards
Joe
__________________
A Proud webmaster to the internet's most informed, educated, COMPASSIONATE and caring group of breast cancer survivors.
Illegitimi non carborundum
My Album
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12-19-2006, 04:45 AM
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#3
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Senior Member
Join Date: Dec 2005
Posts: 274
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Thank you Joe
Thanks Joe,
I will check that book out. I knew I could count on you. I am sure this will put lots of things into perspective.
Sincerely,
Liz J.
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12-19-2006, 07:14 AM
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#4
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Senior Member
Join Date: Aug 2003
Location: Morris, IL
Posts: 3,507
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Liz
I do know that my Mom was diagnosed in the '80's and was not tested, but despite this and 13 positive nodes, she is a 20 year survivor only taking tamoxifen
__________________
"Be kinder than necessary, for everyone you meet is fighting some kind of battle."
Hugs & Blessings
Sheila
Diagnosed at age 49.99999 2/21/2002 via Mammography (Calcifications)
Core Biopsy 2/22/02
L. Mastectomy 2/25/2002
Stage 1, 0.7cm IDC, Node Neg from 19 nodes Her2+++ ER PR Neg
6/2003 Reconstruction W/ Tissue Expander, Silicone Implant
9/2003 Stage IV with Mets to Supraclavicular nodes
9/2003 Began Herceptin every 3 weeks
3/2006 Xeloda 2500mg/Herceptin for recurrence to neck nodes
3/2007 Added back the Xeloda with Herceptin for continued mets to nodes
5/2007 Taken Off Xeloda, no longer working
6/14/07 Taxol/Herceptin/Avastin
3/26 - 5/28/08 Taxol Holiday Whopeeeeeeeee
5/29 2008 Back on Taxol w Herceptin q 2 weeks
4/2009 Progression on Taxol & Paralyzed L Vocal Cord from Nodes Pressing on Nerve
5/2009 Begin Rx with Navelbine/Herceptin
11/09 Progression on Navelbine
Fought for and started Tykerb/Herceptin...nodes are melting!!!!!
2/2010 Back to Avastin/Herceptin
5/2010 Switched to Metronomic Chemo with Herceptin...Cytoxan and Methotrexate
Pericardial Window Surgery to Drain Pericardial Effusion
7/2010 Back to walking a mile a day...YEAH!!!!
9/2010 Nodes are back with a vengence in neck
Qualified for TDM-1 EAP
10/6/10 Begin my miracle drug, TDM-1
Mixed response, shrinking internal nodes, progression skin mets after 3 treatments
12/6/10 Started Halaven (Eribulen) /Herceptin excellent results in 2 treatments
2/2011 I CELEBRATE my 9 YEAR MARK!!!!!!!!!!!!!
7/5/11 begin Gemzar /Herceptin for node progression
2/8/2012 Gemzar stopped, Continue Herceptin
2/20/2012 Begin Tomo Radiation to Neck Nodes
2/21/2012 I CELEBRATE 10 YEARS
5/12/2012 BeganTaxotere/ Herceptin is my next miracle for new node progression
6/28/12 Stopped Taxotere due to pregression, Started Perjeta/Herceptin
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12-19-2006, 02:31 PM
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#5
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Senior Member
Join Date: Sep 2005
Location: Alaska
Posts: 2,018
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Her2, old or new....
Well, wouldn't there be some fairly ancient preserved tumors around from other tumor studies done a decade or more ago that could still be sampled for HER2?
A.A.
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