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View Poll Results: Accuracy of HER2 testing
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I was diagnosed before HER2 testing was commonly done/don't know if I was tested
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1 |
2.27% |
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I was originally tested with IHC and later retested with FISH or CISH at a major cancer center
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22 |
50.00% |
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I have been tested only with IHC, and the test was analyzed at a local cancer center
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4 |
9.09% |
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I have been tested only with IHC, and the test was analyzed at a major cancer center
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7 |
15.91% |
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I have only been tested with FISH or CISH
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10 |
22.73% |
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12-13-2006, 01:41 PM
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#1
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Senior Member
Join Date: Sep 2005
Location: Alaska
Posts: 2,018
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HER2 Testing Accuracy
See Articles Forum post on Accuracy of HER2 testing for reason for poll.
(I hope I get this right as I haven't used the poll option for quite a while...)
Thanks
AlaskaAngel
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12-13-2006, 07:14 PM
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#2
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Senior Member
Join Date: Sep 2005
Posts: 312
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I had both tests, but don't know who examined them. IHC+++. I do know that when a sample was sent to Sloan Kettering, they could not retest the FISH. Whoever did it first, found it postive. 7.6, I think.
__________________
Janet
Endometrial Cancer 2002
Mammogram 11/2004
Lumpectomy 12/2004
Stage 1, 9mm DCIS, grade 2, Her2+++, ER/PR negative
Refused A/C as recommened by two oncs.
35 treatments of radiation that ended March 4, 2005
Changed oncologists and began
Taxotere/Herceptin August 2005. Finished Herceptin July 2006
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12-14-2006, 05:38 AM
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#3
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Senior Member
Join Date: Sep 2005
Location: NYC
Posts: 250
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It makes me nervous when I see that some people were only tested using FISH. It is possible to be negative by FISH, but positve (3+) by IHC. The tests measure Her2 in two different ways. I was negative by FISH, but 3+ by IHC and I would have missed out on Herceptin if my Onc had only relied on FISH. (I had both tests and treatment at a major NYC cancer center).
Jen
__________________
dx 4/05 @ 34 y.o.
Stage IIIC, ER+ (90%)/PR+ (95%)/HER2+ (IHC 3+)
lumpectomy-- 2.5 cm 15+/37 nodes
(IVF in between surgery and chemo)
tx dd A/C, followed by dd Taxol & Herceptin
30 rads (or was it 35?)
Finished Herceptin on 7/24/06
Tamox
livingcured.blogspot.com
"Keep your face to the sunshine and you cannot see the shadow." -- Helen Keller
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12-14-2006, 07:33 AM
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#4
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Senior Member
Join Date: Sep 2005
Location: South Dakota.
Posts: 621
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My onc did IHC first: 2+
He then sent it for FISH testing: 8.6
I guess if IHC comes back as a 2, more testing is needed.
As of about a year ago, my onc felt that FISH was more reliable, and stressed the fact that testing needs to be done at a large lab where testing is frequently done.
__________________
Blessings and Peace,
Barbara
DX Oct 02 @ age 52 Stage 2B Grade 3 Mastectomy
"at least" 4.5 cm IDC 1+node ER+61% /PR-
Assiciated Intraductual component with Comedo Necrosis
Her2+ FISH8.6 IHC 2+
5 1/2 CEF Arimidex
Celebrex 400mg daily for 13 months
Prophylactic mastectomy
Estradiol #: 13
PTEN positive, "late" Herceptin (26 months after chemo)
Oct 05: Actonel for osteopenia from Arimidex.
May 08: Replaced Actonel with Zometa . Taking every 6
months.
Accepting the gift of life, I give thanks for it and live it in fullness.
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12-14-2006, 09:09 AM
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#5
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Senior Member
Join Date: Feb 2006
Location: Acworth, GA
Posts: 2,104
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Usually if you are tested by IHC and it is 2+ or more you are then tested via FISH method. For HER2 clinical trials I believe that you must test HER2+ by FISH method.
__________________
Kate
Stage IIIC Diagnosed Oct 25, 2005 (age 58)
ER/PR-, HER2+++, grade 3, Ploidy/DNA index: Aneuploid/1.61, S-phase: 24.2%
Neoadjunct chemo: 4 A/C; 4 Taxatore
Bilateral mastectomy June 8, 2006
14 of 26 nodes positive
Herceptin June 22, 2006 - April 20, 2007
Radiation (X35) July 24-September 11, 2006
BRCA1/BRCA2 negative
Stage IV lung mets July 13, 2007 - TCH
Single brain met - August 6, 2007 -CyberKnife
Oct 2007 - clear brain MRI and lung mets shrinking.
March 2008 lung met progression, brain still clear - begin Tykerb/Xeloda/Ixempra
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12-15-2006, 01:37 AM
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#6
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Senior Member
Join Date: Apr 2006
Posts: 148
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2+ / 3+
Here in the UK, they do the FISH test if you are in the IHC 2+ zone (as I was). If you are 3+, I don't think they do.
We seem to be a long way behind you. For example, I asked my onc about doing the Ki67 (proliferation test) and the Oncotype test. He said it was not protocol yet - lack of funds, if you ask me!
So I am relying on their current knowledge which is not to prescribe chemo or herceptin for node negative, vascular negative, hormone positive, small weakly positive HER2 tumours in post-menopausal women. I just hope they are right!
Mcgle
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12-17-2006, 06:07 PM
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#7
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Senior Member
Join Date: Sep 2005
Location: Alaska
Posts: 2,018
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insurance coverage for retesting
I thought I would tack this news article here, in case it is helpful to anyone who happens to have this coverage, or finds it meaningful:
<!-- / icon and title --><!-- message --> http://webcenters.netscape.compuser.../0907279601.htm
<!-- / message --> |
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