this article shows increased risk of second cancers particularly in areas which may be affected by standard radiation therapy ie, esophagus, nonHodgkin's lymphoma (perhaps due to radiation of the thymus gland) etc.
APBI radiates only the excision cavity rather than the whole breast and thus is associated with a lower dose to "innocent bystander" adjacent tissue
Full Paper
British Journal of Cancer advance online publication 3 October 2006; doi:10.1038/sj.bjc.6603404
www.bjcancer.com
Family history of breast cancer and young age at diagnosis of breast cancer increase risk of second primary malignancies in women: a population-based cohort study
M Prochazka1, P Hall1, F Granath2 and K Czene1
1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, SE-171 77 Stockholm, Sweden
2Department of Medicine at Karolinska University Hospital, Clinical Epidemiology Unit, SE-171 76 Stockholm, Sweden
Correspondence to: Dr M Prochazka, E-mail:
Michaela.Prochazka@ki.se
Received 10 July 2006; revised 23 August 2006; accepted 6 September 2006; published online 3 October 2006
Among 152 600 breast cancer patients diagnosed during 1958-2000, there was a 22% increased risk of developing a second primary non-breast malignancy (standardised incidence ratio (SIR)=1.22; 95% confidence interval (CI): 1.19-1.24). The highest risk was seen for connective tissue cancer (SIR=1.78; 95% CI: 1.49-2.10). Increased risks were noted among women diagnosed with breast cancer before age 50. Oesophagus cancer and non-Hodgkin's lymphoma showed six- and four-fold higher risks, respectively, in women with a family history of breast cancer compared to those without in the 10-year follow-up period.
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