cruciferous veges (broccoli,brussel sprouts) in maternal diet helps protect her

[Lani]

yet-to-be -born child against cancer according to the following:


1: Carcinogenesis. 2006 May 16; [Epub ahead of print] Links
Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by the polycyclic aromatic hydrocarbon, dibenzo[a,l]pyrene.

Yu Z,
Mahadevan B,
Lohr CV,
Fischer KA,
Louderback MA,
Krueger SK,
Pereira CB,
Albershardt DJ,
Baird WM,
Bailey GS,
Williams DE.
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR; The Linus Pauling Institute, Oregon State University, Corvallis, OR.
The fetus and neonate are sensitive targets for chemically induced carcinogenesis. Few studies have examined the risk/benefit of chemoprotective phytochemicals, given in the maternal diet, against transplacental carcinogenesis. In this study, B6129 SF1/J (AHR(b-1/d)) and 129Sv/ImJ (AHR(d/d)) mice were cross bred. The polycyclic aromatic hydrocarbon, dibenzo[a,l]pyrene (DBP), was administered to pregnant mice (15 mg/Kg, gavage) on gestation day 17 and 2000 ppm indole-3- carbinol (I3C), a chemoprotective phytochemical from cruciferous vegetables, was fed to half of the mice from gestation day 9 until weaning. Offspring born to dams fed I3C exhibited markedly fewer mortalities (p<0.0001). Maternal dietary exposure to I3C also significantly lowered lung tumor multiplicity (p = 0.035) in offspring surviving to 10 months of age. The I3C chemoprotection was independent of either maternal or fetal AHR genotype. The bioavailability of DBP to fetal target tissue was demonstrated by assessing DNA covalent adduction with a (33)P-post-labeling assay. The bioavailability of I3C was determined by dosing a subset of pregnant mice with [(14)C]-I3C. Addition of chemoprotective agents to the maternal diet during pregnancy and nursing may be an effective new approach in reducing the incidence of cancers in children and young adults.
PMID: 16704990 [PubMed - as supplied by publisher]

[R.B.]

I have seen trials on omega three six etc suggesting possible ability to mitigate future risk of cancer in offspring, by ensuring adequate supplies of omega three and long chain omega threes.

But as usual it is complicated as in certain rarer instances where the mother has an inbility to make any long chain fats omega six can be involved too.

It appears you are what your mother ingested and digested (IBS etc) too.

Interesting posts.

Thank you.

RB