Antiangiogenesis drugs

Sammy · 07-06-2006, 10:14 AM

I have read a lot about various drugs in this forum. How come nobody was given Advexin , which seems to be a good antiangiogenesis drug....? Or is it so that it doesn't work on Her2 tumors...?

StephN · 07-06-2006, 02:47 PM

You can do a search and will find it mostly used with lung and head & neck squamous cell cancers.

They have had success using Advexin with NEOadjuvent cases where they needed to shrink the initial tumor before surgery.
There is info with and without chemos.

AVASTIN is a drug that some women on this site have used. It is another drug that reduces tumors by starving them.

To me this is a good way to go in conjunction with chemos or Herceptin to make the treatment less hard on our bodies.

heblaj01 · 07-06-2006, 02:56 PM

Sammy,

I could not find any info indicating that Advexin is an antiangiogenesis drug.
It is described as made up of "Adenovirus encoding the tumor suppressor p53 gene".
It works by direct injection into tumours (so far tried in head & neck & lungs) to increase the level of normal p53 which cause apoptosis of cancer cells.
In theory it should nevertheless be working in many cancer types since defective p53 are involved in a lot of cancers in other body locations. But I don't know if it can be delivered systemically as opposed to direct injections.
Advexin while receiving fast track status in the US for head & neck is not yet approved as far as I know.

Concerning antiangiogenesis drugs, if one can be discovered that directly inhibits the formation of new blood vessels generated by either malignant cells in existing vessels or by growth factors coming from tumours, it would theorically work on almost all cancers in at least stopping progression of the disease,
But so far, the 2 approved antiangiogenesis drugs are working indirectly by inhibiting one or two of several known growth factors. So eventually other factors are likely to cause progression unless these drugs are combined with fast acting chemo or targetted
therapies such as Herceptin otr tykerb.

heblaj01 · 07-07-2006, 11:22 AM

Sammy,

If you are interested in the subject of antiangiogenesis drugs you may listen at a recent lecture by Dr J. Folkman (initiator of the field of research on antiangiogenesis) by going to this site:

http://www.her2support.org/vbulletin...ad.php?t=24475