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Old 04-07-2006, 04:51 PM   #1
eric
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Tykerb with Herceptin

In Sherry's post she mentioned that her onc is thinking of adding Tykerb to herceptin when able for added protection. I'm wondering if anyone elses doc would consider it. I know they'll be 2 schools of thought...one thinking added protection while the other saving it if and when needed.

Curious about everyone's thoughts.
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Old 04-07-2006, 07:56 PM   #2
Lolly
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Knowing my onc, he'll use it if/when needed; he's of the school of thought that less is more when dealing with metastatic disease.

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Old 04-08-2006, 05:36 AM   #3
Sheila
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Lolly
My Dr and your's seem to be on the same page....she is also a less is more and keep something for later.
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"Be kinder than necessary, for everyone you meet
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Sheila
Diagnosed at age 49.99999 2/21/2002 via Mammography (Calcifications)
Core Biopsy 2/22/02
L. Mastectomy 2/25/2002
Stage 1, 0.7cm IDC, Node Neg from 19 nodes Her2+++ ER PR Neg
6/2003 Reconstruction W/ Tissue Expander, Silicone Implant
9/2003 Stage IV with Mets to Supraclavicular nodes
9/2003 Began Herceptin every 3 weeks
3/2006 Xeloda 2500mg/Herceptin for recurrence to neck nodes
3/2007 Added back the Xeloda with Herceptin for continued mets to nodes
5/2007 Taken Off Xeloda, no longer working
6/14/07 Taxol/Herceptin/Avastin
3/26 - 5/28/08 Taxol Holiday Whopeeeeeeeee
5/29 2008 Back on Taxol w Herceptin q 2 weeks
4/2009 Progression on Taxol & Paralyzed L Vocal Cord from Nodes Pressing on Nerve
5/2009 Begin Rx with Navelbine/Herceptin
11/09 Progression on Navelbine
Fought for and started Tykerb/Herceptin...nodes are melting!!!!!
2/2010 Back to Avastin/Herceptin
5/2010 Switched to Metronomic Chemo with Herceptin...Cytoxan and Methotrexate
Pericardial Window Surgery to Drain Pericardial Effusion
7/2010 Back to walking a mile a day...YEAH!!!!
9/2010 Nodes are back with a vengence in neck
Qualified for TDM-1 EAP
10/6/10 Begin my miracle drug, TDM-1
Mixed response, shrinking internal nodes, progression skin mets after 3 treatments
12/6/10 Started Halaven (Eribulen) /Herceptin excellent results in 2 treatments
2/2011 I CELEBRATE my 9 YEAR MARK!!!!!!!!!!!!!
7/5/11 begin Gemzar /Herceptin for node progression
2/8/2012 Gemzar stopped, Continue Herceptin
2/20/2012 Begin Tomo Radiation to Neck Nodes
2/21/2012 I CELEBRATE 10 YEARS
5/12/2012 BeganTaxotere/ Herceptin is my next miracle for new node progression
6/28/12 Stopped Taxotere due to pregression, Started Perjeta/Herceptin
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Old 04-08-2006, 11:24 AM   #4
StephN
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Wink $Expensive$

My first thought runs to the astronomical cost of a combination of Tykerb and Herceptin for any length of time. The rate I have been going through my lifetime cap for my insurance, I have to think this way.

But, I would not hesitate to ask for it since I AM already a brain mets patient (even though NED now).

It was my first impression that they would exchange Herceptin for Tykerb if Herceptin failed the patient.

As this drug is just becoming available, it will be interesting to see how it works for various people in various situations. And I hope that there will be some posts here on this so we can all see how it is working.
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Old 04-08-2006, 11:56 AM   #5
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I believe that Tykerb would be allowed to administer somebody with MBC (metatastic breast cancer) whose Herceptin has INITIALLY failed her.
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Old 04-08-2006, 12:07 PM   #6
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Oh, Steph just beat me to it. Great minds think alike! :-)
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