ER, PR status with HER2+

Would anyone have information or know where to find statistics concerning
the ER and PR status with HER2+++ cancers.

For example, I am ER+(70%), PR+(30) and HER2+++

Are most HER2+++

1) ER+ and PR+
2) ER+ and PR-
3) ER- and PR-
4) ER- and PR+(not sure if this is a category)

Wondering how each of these effects HER2+++ treatment and effectiveness of treatment.

This thought came to me after reading the article posted by dee concerning tamoxifen efficacy.

Sassy

I don't know where to find the stats, but we could all answer here.

I'm Her2+++

ER 91% PR 62%

Sue

I believe I read that about 50% of Her 2 +++ are also hormone positive.

I am Her2 +++ and ER 50% and PR 5%.

Best reagards,

Becky

I was trying to dig up the article you mentioned but couldn't find it. I'd be very interested in reading it as I've always wondered about tamoxifen and her2. I'm her2+ er+ pr+ but not sure how much er and pr.... where can I find the article?

You have asked a very good question. I often wondered about this also.

I am Her2, Er 10% and Pr 70%. I also am debating on the whole tamoxifen issue. Any info would be helpful.

Lori

I recall reading less than 10% of HER2 + or also ER+.
If I can find the article I'll send it.
Al

Lori,
Here is the info you are looking for.
http://annonc.oxfordjournals.org/cgi...ull/14/12/1697
Al

Linda,

The article I mentioned is under the submitted article forum of this site.


http://www.her2support.org/forums/in...howtopic=22169

Submitted by Dee.

Sassy

I am ER- PR- and Her2+++
Was told this is very aggressive cancer.
Stage 1, Grade 3 with negative sentinal nodes but bioposy path report showed "possible lymph invasion"

[Rozebud]

Yes (4) is a category. I'm in it.

Er-, Pr+ 23%. Would love to know if anyone has info on this type. Me, Nikki from UK and only 2 other people I know are this type - all of us her2+ as well. Only about 1% of cancers are ER-,PR+. Would love to know if it's better or worse than being ER+,PR- (know it's worse than if they're both +).

OK, you got me thinking about something else... what percentage numbers for ER and PR status are considered to be "low" positive??

I am ER+(95%), PR+(30%), Her2+++, stage II

On Arimidex for 2 1/2 years and recently started Herceptin. The research Al listed is one of the reasons I chose to be on Arimidex instead of Tamoxifen.

LindaBL

Rozebud, what I've seen about the minority who are ER-, PR+ is speculation that partly because that group is small, possibly it is due to errors in testing.

Most HER2 +++'s are ER-.

It sounds to me like when it comes to being both HER2+++ and ER+, the more PR+ the better.

AlaskaAngel

When I got a second opinion at Sloan Kettering, I was told I was lucky to also be ER/PR positive since I was Her 2 positive. Being hormone positive is always a good thing even if you are Her 2 (or anything else that is discovered).

So... since this subject came up and today is my Herceptin day, I asked my new (and highly intelligent onco) the question and he said it is always better to be hormone positive - especially now when one can take hormonals and herceptin together.

Best regards

Becky

I had a chance to ask my onc today--I didn't think I would see him. But he came by to tell me my blood tests indicate I will be and should remain post menopausal after chemo. If not, he would do something to make sure so that I could go on AI. He had been non commital until the test results came back.

This was my main reason for finding stats on hormone status. I posed the stats question to my onc and he said about 50% of her2+ are er+. In the general breast cancer population about two thirds are ER+. Being er+ is good in either case because of hormonal treatment and the percentage of positive is only a factor if it is very low perhaps, 10% or less.

As for pr status, he did not feel it carried much significance, the er status was most inportant. I did ask if er- pr+ was a category and he said it was. It was almost always found only in her2+++ cancers. He thought the pr+ was related to the her2 overexpression.

Sassy

Sassy,
what did your onc mean by percentage was only significant if your er is less than 10%?

He didn't say percentage was only significant if less than 10%. He was saying that any level positive was good--only questionable if very low 10% or less.

Sassy

I guess it depends on whether one is thinking in terms of ANY hormone-receptor positivity (ER/PR) or just ER or just PR....?

"In agreement with previous studies (32,33), we found an inverse
relationship between ER/PR expression and HER2 (Table IV).
ER/PR positive tumors tend to lack HER2 overexpression
and conversely, HER2 overexpressing tumors tend to be
ER/PR negative...."


http://147.52.72.117/IJO/2001/volume.../1155-1160.pdf


and in a study of 366 women, "ER-positive and HER2-negative tumors were found in 221 patients (60.4%), ER-negative and HER2-negative in 71 (19.4%), ER-negative and HER2-positive in 46 (12.6%), and ER-positive and HER2-positive in 28 (7.7%)".


http://meeting.jco.org/cgi/content/a...3/16_suppl/900


Out of the 366, 249 (68.1%) were positive for ER and 74 (20.2%) were positive for HER2.

60.4% ER+, HER2-
19.4% ER-, HER2-
12.6% ER-, HER2+
7.7% ER+, HER2+

One of my tumors was entirely ER/PR negative and a smaller one just next to it was ER 5% pos and PR neg. Both were HER2 +++

Anyone else have this? And yes, I had the tumors sent out for a 2nd opinion and results were the same as 1st time.

I'm on Tamoxifen for that 5%. It seems whether you are 5% pos or 95% positive you are "classified" as positive.

Keep in mind, our HER2 positive tumors react very well to chemo- so I am counting on that factor !!!

Maria

maria,
I had a tumor that is 5% er and pr-, her2+ and they are calling me estrogen negative. I was unaware that you could take tamoxifen for 5%.
Penny