Dear Ladies,
Sorry for not replying sooner but I cleaned the cookies off my laptop and forgot that it also cancels the "new message" function from the list.
Cathy,
The DPD deficiency can kill you if you were to continue taking Xeloda. I'm surprised they gave it to you a second time. This enzime nuetralized 5FU (which xeloda turns into) therefore you were over-dosing on the 5FU. Here is an article:
www.pslgroup.com/dg/24cBca.htm
Patti,
The manufacturer's insert states that the doseage can be lowered first by 75% and again by 50% if required (due to dose limiting side effcts). This effacy of the drug due to the dose reduction is very well documented in numerous trials. It's just that the starting dose was set so high during the initial trials that dose reduction doesn't effect any of the treatment end points. Nose bleeds are also mentioned in the manufacturer's insert and taking coudamine or aspirine or any other blood thinners is contraindicated.
Have a great weekend,
Al
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