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Hi all,
I realized there are about six different topics I wanted to post under and thought maybe I'd just start a new thread rather than do that.
There is so much information to digest from SABCS that I just wanted to offer what is probably an obvious hint. If you go to sabcs.org and register (no $ or anything, just have to give some info) you can then search their online database of all the abstracts that were just presented last week. The great thing, I find, is that you can search by keyword: for instance if you type in "her2" you get 78 hits, and find abstracts ranging from the most basic (way above my head) bench science to the most obvous all-you-folks-know-this-already confirmation of what's happening in practice.
If you type in "vaccine" you'll get a handful of hits...
If you are interested in attempts to target more than one pathway try typing in "trastuzumab" and "gefitinib" or "her1" and "her2" or something like that. There is info that the combo herceptin/iressa was a washout. But there is more hopeful stuff about other targeted therapies like pertuzumab and erlotinib. Also, look up lapatinib (572016) and you'll find a few things too...
For those of you interested in complementary and alternative approaches, there was even one promising abstract about IP6!
As some of you have noted there is no info yet on the adjuvant trials. But if you type in "neoadjuvant" you will find some stunning info, inlcuding one small trial where neoadjuvant chemo + herceptin resulted in something like a
75% complete response rate. Some folks think complete response rate in neoadjuvant trials corresponds with ultimate overall survivall, so this is really good news.
Don't know if all this muddies the waters more, but I've found it a helpful way to navigate through all the news...
Hope you all are well today. Yesterday marked Rachel's two year anniversary from time of her original diagnosis!
Best,
Jeff
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