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Hope,
My apologies for this late addition. I have managed to find one 2002 Japanese IN VIVO (i.e., in animals) study that found Xeloda "additive" (arguably "synergistic" based upon the study graph presented) to herceptin rather than "antagonistic."
Importantly, the Japanese study abstract specifically recognizes a "past study" (i.e., the Pegram study) that finds Xeloda "antagonistic" to Herceptin based upon IN VITRO testing. The study abstract notes the discrepancy between the "antagonistic" result in the test tube and the "additive" result in animals. No explanation is given for the difference. It shows that test tube results may change when a drug is introduced into a living organism. I must say, I could find very little on this issue and would still recommend that you discuss the issue with UCLA or UCSF.
I have also found one more active clinical study that combines taxotere, Herceptin and Xeloda. The study is being conducted at UCSF. I will provide a cross-link below this post with respect to the UCSF clinical study. The study summary lists a contact at UCSF. If necessary, you can contact that individual and discuss this issue.
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