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Old 05-31-2006, 05:41 PM   #1
dlaxague
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Question New prognostic figures/adjuvant Herceptin?

Hi all,

I haven't been a member of this list although I do read it occasionally and have posted a few times in the past ('don't remember having to register to do that before).

I figure that if there is an answer to this question, someone here will have it:

Do we know which tumor has the better prognosis, if matched for all details except HER2neu status - the HER2+ one treated adjuvantly with Herceptin and appropriate chemo/hormonals, or the HER2- one treated with the same appropriate chemo/hormonals?

I know that we do not have enough evidence to say for sure. But there must be speculation?

TIA,
Debbie
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Old 05-31-2006, 07:09 PM   #2
Becky
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I believe that adjuvant Herceptin levels the playing field as far as disease free survival is concerned. There is not enough data yet to make a determination on overall survivability (since the Herceptin adjuvant trials began in 2000). Time will tell.


Kind regards

Becky
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Old 05-31-2006, 07:42 PM   #3
LovingDaughter
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I have read the same as Becky.
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Caregiver to mother, Diane
Diagnosed 3/2006 Stage IIB (T2, N2, M0), Her-2+++, Er/PR-, Grade 3
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Old 06-01-2006, 05:24 AM   #4
tousled1
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HER2 positive breast cancer is a more agressive cancer and has a higher rate of recurrence. With the herceptin recurrence rates have been lowered.
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Stage IIIC Diagnosed Oct 25, 2005 (age 58)
ER/PR-, HER2+++, grade 3, Ploidy/DNA index: Aneuploid/1.61, S-phase: 24.2%
Neoadjunct chemo: 4 A/C; 4 Taxatore
Bilateral mastectomy June 8, 2006
14 of 26 nodes positive
Herceptin June 22, 2006 - April 20, 2007
Radiation (X35) July 24-September 11, 2006
BRCA1/BRCA2 negative
Stage IV lung mets July 13, 2007 - TCH
Single brain met - August 6, 2007 -CyberKnife
Oct 2007 - clear brain MRI and lung mets shrinking.
March 2008 lung met progression, brain still clear - begin Tykerb/Xeloda/Ixempra
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