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Old 01-06-2008, 08:38 AM   #1
CLTann
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Join Date: Oct 2005
Posts: 476
Denosumab, for bone loss prevention

In the recent San Antonio Conference, a very favorable report was presented for the AI associated bone density loss. Denosumab is a twice a year injection treatment. Do any of you know whether this is available or it is still under FDA review? I am taking Fosamax and having stomach pain side effects. What are the alternate treatments? The nose sprays are hormone based treatment and they may counter the purpose of AI.
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Ann

Stage 1 dx Sept 05
ER/PR positive HER2 +++ Grade 3
Invasive carcinoma 1 cm, no node involvement
Mastec Sept 05
Annual scans all negative, Oct 06
Postmenopause. Arimidex only since Sept 06, bone or muscle ache after 3 month
Off Arimidex, change to Femara 1/12-07, ache stopped
Sept 07 all tests negative, pass 2 year mark
Feb 08 continue doing well.
Sep 09 four year NED still on Femara.
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Old 01-06-2008, 05:39 PM   #2
sassy
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Location: Mountains of Virginia
Posts: 2,267
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Ann,

I did not tolerate Fosamax well either. My onc wanted to get me on Zometa as soon as possible. After a bone density test indicated opsteopnia, my insurance approved it. I think there were some presentations at ASCO on Zometa.
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Rhonda (Sassy)
dx age 45
DX 2/15/05 Stage IIb (at surgery)restaged IIIa
Left mast .9cm tumor 5 of 14 nodes
Triple Positive
4 DD A/C
12 Taxol/Herceptin
33Rads
Strange infect mast site one year aft surg, hosp 1 wk
Herceptin for total of 18 months
Lupron Monthly 4 yrs
Neurontin for aches, pains and hot flashes(It works!)
Ovaries removed 11/09 stop Lupron and Neurontin
Arimidex 6 yrs (tried Femara, no SE improvement)
Tried Exemestane-hips got so bad could hardly walk
Back to Arimidex for year seven
Zometa 2X Annual for 7years, Lasix
Stop Arimidex 5/13
Stop Zometa 7/13-Bi-lateral Stress Fractures in Femurs from Zometa
5/14 Start Tamoxifen
3/15 Stem cell transplant to stimulate femur bone growth/healing
5/15 Complete fracture of right femur/Titanium rods both femurs
9/16 Start Evista stopTamoxifen
3/17 Stop Evista--unwelcome side effects!
NED and no meds.......
14YEARS NED!
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Old 01-08-2008, 03:28 PM   #3
Petesmom
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Join Date: Sep 2005
Posts: 49
There is an unfavorable report about bisphosphonates on Medscape Today that I saw a few minutes ago. I cannot tolerate Fosamax either as it seems to potentiate the symptoms I was having in terms of aching joints and bone pain from Arimidex. Check it out.

Petesmom
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Petesmom

"Treat each day as a new life"

Diagnosis
1998 IDC, 8mm tumor; node neg Her2-; ER/PR + lumpectomy right breast; rads; Fareston for 5 yrs;
2005 recurrence right breast; DCIS with IDC 7mm (total involvement), Her2+++. ER/PR+; simple mast; prophylactic ooph; Arimidex only
NED
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