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Old 08-07-2006, 07:24 PM   #1
Ceesun
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Navelbine And Xeloda W/ Herceptin

I AM STARTING IN A CLINICAL TRIAL WITH THESE 2 DRUGS ALONG WITH HERCEPTIN DUE TO A LUNG NODULE IN 2 WEEKS AFTER MY VACATION-MY ONCOLOGIST SAYS NOT TO CHANGE MY PLANS. hAS ANYONE HAD BOTH OF THese DRUGS ALONG WITH HERCPTIN? hAS ANYONE HAD LUNG METS THAT HAVE RESOLVED?? Ceesun
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Old 08-07-2006, 08:25 PM   #2
chrisy
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Ceesun,
I have not had this combination of drugs or lung mets. There are lots of women on this board who have had lung mets resolve completely. Read Christine's birthday message for starters! I'm sure you will get many responses from others who can give you their personal experiences.
Good luck on the new combo!
Chris
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June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial

5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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Old 08-07-2006, 08:42 PM   #3
al from Canada
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Ceeson,
This is a very active and I thought proven combination, and I'm surprised it is still in clinical trials. Navelbine has been used specifically for lung mets, as it was first used in lung cancer, and xeloda is a pro-drug to 5-FU which is a good all round chemo. Provided the dosage is right, it should be well tolerated and hopefully, this combination will resolve your mets. Both are highly synergistic with herceptin.
Good luck,
Al
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Old 08-07-2006, 09:23 PM   #4
Sherryg683
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I had two small lung mets, they were treated with Herceptin, Xeloda, and Taxotere. They were gone after 6 weeks of treatment, I stayed on treatment for 4 months and was NED in April. ...sherryg683
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Old 08-08-2006, 04:45 PM   #5
Ceesun
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thanks to those who have responded- I will let you know how it goes. Al, you sound a bit like my bro who is a chemist??!! And I say that respectfully. My condolences on your loss Ceesun aka Cathy
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