Unusual, but not necessarily wrong
I have heard of anthracyclines being given after the herceptin + taxane combos in trials, with good results and minimal cardiotoxicity, although the trials I can think of were fairly small. The problem with putting adriamycin first is that herceptin can aggravate problems set in motion by adriamycin, so the idea is that if you start with the herceptin-based chemo, the there isn't any prior damage for the herceptin to worsen the situation and there wouldn't be a gap before the adriamycin. Are you getting a herceptin tail or none? I would imagine not.
If your oncologist is a breast cancer specialist and the type who really knows what is going on, it may be that he or she knows something that we don't know about some trial that is underway, although your treatment is rather unusual. The big trials using adriamycin all put it first, but, as I mentioned, this may have not been the best way of doing it in terms of heart problems.
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