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There are no studies on small tumors in general but all the clinical trials used women who had tumors that were 1 cm or greater. Your wife's tumor is slightly larger than 1cm. She is also young and has a lot of life to live. Herceptin is an easy drug to take (the first 2-3 are tiring but it is a breeze drug) and because she is young (and presumably very healthy otherwise), the chances of having cardio problems is low. And if it occurs, they just stop the Herceptin as the problems are reversible.
I was 45 (47 now) and although my tumor was larger (1.9cm) I did not hesitate in order to see my daughters grow up and my potential grandchildren. The every 3 week dosing does not get in the way of lifestyle at all and it boosts the survival rate by 52% (and you can't beat that).
Kindest regards
Becky
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