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One thing we do know is that HER2 and ER status is variable and may change as the disease progresses. This has major implications for HER2 (-) BC as many may have HER2++ as the disease changes and do not know it and may have benefit grom herceptin. ER+ resistance can be reversed with administration of a HER1 inhibitor such as iressa, lapatinib or tarceva.
Al
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Primary care-giver to and advocate for Linda, who passed away April 27, 2006.
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