Re glty's link re melatonin
Again another potentially benificial agent that appears to act in the area of lipids and insulin.
RB
http://groups.google.co.uk/group/sci...99cb3673714b7c
ABSTRACT
Melatonin also reduces serum lipid levels in mammalian
species, and helps to prevent oxidative stress in diabetic subjects.
Long-term melatonin administration to diabetic rats reduced their
hyperlipidemia and hyperinsulinemia, and restored their altered ratios
of polyunsaturated fatty acid in serum and tissues. It was recently
reported that melatonin enhanced insulin-receptor kinase and IRS-1
phosphorylation, suggesting the potential existence of signaling
pathway cross-talk between melatonin and insulin. Because TNF-alpha has
been shown to impair insulin action by suppressing insulin
receptor-tyrosine kinase activity and its IRS-1 tyrosine
phosphorylation in peripheral tissues such as skeletal muscle cells, it
was speculated that melatonin might counteract TNF-alpha-associated
insulin resistance in type 2 diabetes. This review will focus on the
physiological and metabolic effects of melatonin and highlight its
potential use for the treatment of cholesterol/lipid and carbohydrate
disorders.