Tamoxifen and Herceptin

Hi Al,
Thanks for the response. I've read that article before, and while it says that Her2 positive cancers are more resistant to hormonal therapy, Tamoxifen in particular, it actually recommends combining Herceptin with Tamoxifen or to an A.I. to restore sensitivity to the hormonal therapy. In other words, by adding Herceptin you take away the Her2 component of the cancer so it responds like a normal cancer to the hormonal therapy.

A.I.'s have proven to be more effective than Tamoxifen so you would assume that there would be even greater efficacy when combining an A.I. with Herceptin as opposed to Tamoxifen, but in the adjuvant setting you can't take Herceptin for years, at least at this point in time. So we're looking to safely squeeze as much "mileage" out of the Herceptin/Tamoxifen combination before switching to an A.I. where Herceptin will probably be out of the picture at that point.

So, I really haven't come across any hard data from the combination of either of the drugs with Herceptin just theory on why they believe the therapy would be effective. Al, I know you read a lot of articles on this and maybe you can point me to some that have some efficacy data or if anyone else that has come across some data it would be greatly appreciated.

Thanks again,

Scott