Herceptin for HER2+++'s who have never had it

My question re. the Hecpetin trials is: for those who DID have a recurrance, how soon was it, and WHERE was the recurrance? As Herceptin doesn't cross the BBB, then I'd be concerned that a recurrance after Herceptin would be more likely to be in the brain, which has fewer treatment options then say bones, liver.

I haven't seen any details about the people in these trials who did recurr. Why not? I didn't have Herceptin back in 2002 with my initial treatment, but would maybe consider it now if there was strong favorable evidence, but it seems that it really has to be taken with taxol, and I hated Taxol! What to do, what to do??

Marianne