Why Capecitabine and Exemestane?

[donocco]

Exemestane (Aromasin) while being an Aromatase inhibitor like Arimidex has a steroid chemical structure like Estrogen. The other 2 dont and this may explain the different mechanism of action that Beckhy mentioned.

Cant say much about the Xeloda yet. This may help a bit. Xeloda is an oral prodrug of the usually IV given 5 flourouracil. Possibly the fact that it can be given orally is a factor. As far as insurance is concerned, price may be a factor. If this realy concerns you Nguyen Ill try to research it. Im busier retired now than I was working. Really in to increasing my astrology knowledge (plus learning something about all the new drugs) but if this really bothering you Ill see what I can find.


Paul

[donocco]

Nguyen

I called Novartis the makers of Affinitor. The reason they used Exemestane when the drug was first approved was that the clinical trials with Affinitor was
done on patients who were on Arimidex or Letrozole and progressed. This was
I believe was Bolero-2.

Now there is a Bolero-4 trial which did combine affinitor with Letrozole instead of Aromasin. The clinical oncologist at Novartis is going to e mail me it. From what he told me on the phone about the efficacy it may not be important which AI you use. He is going to E mail me both the Aromasin and Letrozole (with Affinitor) trials so I can visually compare the results. Ill let you know what I find.

Paul