Resveratrol--interpret this article?

[donocco]

VDC

Ill mention Berberine. This has antidiabetic and and anticancer action. There is a phenomenon called epithelial-to mesenchymal transition that is important in metastasis. I believe this is a change in cell shape that causes cancer cells to be more motile and able to metastasize. Berberine seems to inhibit this.

Look up Cimetidine brand name Tagamet. It is now (for years) an over the counter histamine 2 blocker antacid. Tagamet intereferes with the production of
E-Selectin, a protein that forms on the endothelial cells that line the small blood vessels. This protein attaches to c protein found on many cancer cells called I believe Lewis Sialyl antigen. When the cancer cells hook onto the E Selectin in te small blood vessels it aids metastasis. Cimetidine is only effective against those cancers that produce the sialyl antigen but if the cancer is metastatic one it is a good guess they are doing this. Cimetidine is a drug of relatively low toxicity although it can act as an enzyme inhibitor increasing the serum levels of certain drugs.

The effect of Cimetidine has been dramatic. They did one study with colon cancer patients. This was done decades ago. One half the patients were given 800mg Cimetidine daily I think starting before surgery and continued for one year. They looked at 10 year survival. It was something like 85% for the colon cancer group getting the Cimetidine daily and 49% for those just on sugery plus oral f flurouracil. The cimetidine patients also got the daily 5-FU so the survival was unlikely to be due to the Cimetidine alone. Im sure you will find this info on google or pub-med. This was colon cancer so you cant say this applies to other cancers. But the E Selectinvs Siallyl antigen thing seems to be general and not cancer specific. See what you find

Paul

PS Other Histamine 2 antagonists such as Zantac (Ranitidine) and the others dont seem to have this anti E Selectin effect. Common sense would say they would. Pharmacology isnt common sense many times.

[VDC]

Ah yes, Berberine! I've been taking Berberine for about 3 months.

Actually I'm on a smorgasbord of things!
IP-6, inositol hexaphosphate
Indole-3-Carbinol
Trans Resveratrol
Quercetin
Evening Primrose oil
Co Q 10
Cranberry extract
Grape Seed Extract
Curcumin
Flaxseed Lignan
Vit D
Flaxseed oil
Aspirin
Rosemary
Green tea extract
Dietary ground flaxseed (and I HATE the stuff)
Cinnamon
Berberine
Spirulina
pecans
Melatonin
Aloe Vera
Niacin



Levothyroxin
Atorvastatin
Cyclobenzaprine
Estrogen/Progesterone (yeah, I know........)


I can't begin to tell you the number of hours I have spent reading articles on these supplements in the medical journals...... but I'm used to it, I've been researching HoFH for over sixteen years!

My operating thought is: 1. is there any scientific indication that it MIGHT be beneficial? 2. Is there any scientific indication it could be harmful? 3. Are there any harmful interactions with supplements or medications that I'm already taking.

I am willing to accept that I may be spending money on useless supplements, but as long as they are not harmful, I find it acceptable. I am also willing to accept that much is not known about many of these supplements which means some of them could indeed be harmful. Which is why I often ask for complete metabolic panels to be run....just to catch any harmful side effects. (so far there have been none)

I now have reason to believe that something in my list of supplements is deleterious to cancer. After all, in the last three months the extent of my disease has shrunk by 30% with no other treatment other than these supplements. I will probably never know which supplement, or combination of supplements is in play here.

I will be very curious to see what the next few months bring!