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Old 04-09-2015, 04:44 PM   #1
Dakini52
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Join Date: Jan 2010
Location: Edmonds, WA
Posts: 202
Re: Just Herceptin and Perjeta - side effects

Has anyone had an allergic reaction to Perjeta? One treatment and I am back to Herceptin only. Had some serious breathing issues and am now going in for a CT of my lungs and a Muga for the heart. My onc says no Perjeta until they figure out what's going on. Just thought I would ask if anyone else had issues with this new drug. Also was allergic to Tykerb but thankfully Herceptin alone has kept me NED for over 5 years now so fingers crossed that it keeps on working :-)
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Diagnosed June, 2006 HER2+++, ER- PR-, Grade 3, Stage IIB. Modified radical mastectomy, radiation, chemo, Herceptin, Tykerb 1 year. [*]In remission until 2/2010. Small tumor detected on chest wall during routine scan. 2/2010 surgery to remove tumor, started Herceptin/Tykerb, follow up radiation. [*]12/26/2010 - Off Tykerb due to allergic reaction[*]12/16/2014 - Have continued on Herception for almost 5 years now and remain NED. Discussion with onc re adding Perjeta to the Herceptin as another way of preventing recurrence. Still in discussion phase. 12/26/14 Onc applying for approval for Perjeta.
Perjeta approved and I received one infusion. It had an immediate impact to my lungs and I experienced difficulty breathing so.....I'm going to be sticking with just Herceptin. Still looking for a good vaccine program to enroll in.

Debbie K
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Old 04-13-2015, 06:29 PM   #2
laura4252
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Join Date: Jan 2011
Location: Colorado Springs, Colorado
Posts: 18
Re: Just Herceptin and Perjeta - side effects

My lungs have gotten a lot worse since I started Perjeta three months ago......my onco has not suggested Perjeta might be implicated......I wonder......Looking at trying Abraxane in two weeks......
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2005: DCIS Stage 0, Right breast, High grade, lumpectomy, radiation, no mastectomy 2009: Diagnosed Her2 new+++, Herceptin only (toxic reaction to Taxotere). Great response to Herceptin 2011 lung mets 2012 tried several targeted chemos- none worked
2013 TDM1- good job resolving some lung mets 2014 Took a treatment break, Oct. Allergic reaction to Doxil 2015 Herceptin & Perjeta
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