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Old 11-09-2014, 02:37 PM   #1
Lauriesh
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Join Date: Oct 2005
Location: Lakeville, Minnesota
Posts: 199
Re: Serum HER-2 - Do You or Don't You?

I have had it run a few times over the last few years.
Mine jumped around from 7-11. I have been Ned for almost 4 years, so it is hard to say if it is accurate. I wish I would have asked to have it run when I was first diagnosed with liver mets to see if the number would have been out of the normal range.
I think it is only reccomended for use in stage 4, not in early stage.

Laurie
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diagnosed stage 2- 3/2005
4.5 cm & 2+ nodes , er/pr- & HER2+
4 AC
12 taxol/Herceptin
Year of Herceptin
liver mets- July-2010
7 taxotere/Herceptin
RFA- Feb.2011
NED
U of Wa vaccine trial-oct 2011-Feb 2012
Herceptin/tykerb
Ned - 2 1/2 years
Herceptin & perjeta
Ned 3 years
Herceptin- reducing treatments , due to s/e, to 5-6 a year
NED- 3 1/2 years
Ned - 4 years
2/15- stopped herceptin - on no treatment
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Old 11-10-2014, 03:45 PM   #2
StephN
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Join Date: Nov 2004
Location: Misty woods of WA State
Posts: 4,128
Re: Serum HER-2 - Do You or Don't You?

I was away from my computer or would have replied.

Laurie is correct. Her2 Elisa serum test has been for use in advanced stage monitoring. I have had this blood test as part of my monitoring toolbox for several years. I now have it run only 2 times per year, and my insurance still pays for it.

My numbers stay in the midrange and are steady. I have been off Herceptin now almost 6 years, which was never supposed to happen for someone in a stage IV remission. I only have a CT scan once a year and use the blood markers as a possible tipoff that something maybe activating during the rest of the year.
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"When I hear music, I fear no danger. I am invulnerable. I see no foe. I am related to the earliest times, and to the latest." H.D. Thoreau
Live in the moment.

MY STORY SO FAR ~~~~
Found suspicious lump 9/2000
Lumpectomy, then node dissection and port placement
Stage IIB, 8 pos nodes of 18, Grade 3, ER & PR -
Adriamycin 12 weekly, taxotere 4 rounds
36 rads - very little burning
3 mos after rads liver full of tumors, Stage IV Jan 2002, one spot on sternum
Weekly Taxol, Navelbine, Herceptin for 27 rounds to NED!
2003 & 2004 no active disease - 3 weekly Herceptin + Zometa
Jan 2005 two mets to brain - Gamma Knife on Jan 18
All clear until treated cerebellum spot showing activity on Jan 2006 brain MRI & brain PET
Brain surgery on Feb 9, 2006 - no cancer, 100% radiation necrosis - tumor was still dying
Continue as NED while on Herceptin & quarterly Zometa
Fall-2006 - off Zometa - watching one small brain spot (scar?)
2007 - spot/scar in brain stable - finished anticoagulation therapy for clot along my port-a-catheter - 3 angioplasties to unblock vena cava
2008 - Brain and body still NED! Port removed and scans in Dec.
Dec 2008 - stop Herceptin - Vaccine Trial at U of W begun in Oct. of 2011
STILL NED everywhere in Feb 2014 - on wing & prayer
7/14 - Started twice yearly Zometa for my bones
Jan. 2015 checkup still shows NED
2015 Neuropathy in feet - otherwise all OK - still NED.
Same news for 2016 and all of 2017.
Nov of 2017 - had small skin cancer removed from my face. Will have Zometa end of Jan. 2018.
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Old 11-12-2014, 04:31 AM   #3
MargaretAlice
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Join Date: Nov 2014
Posts: 10
Re: Serum HER-2 - Do You or Don't You?

Thanks for sharing. I am going to do a baseline. Good to know that it is utilized by some of you.
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Old 11-15-2014, 12:08 PM   #4
Kim in CA
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Join Date: Sep 2001
Location: California's Gold Country
Posts: 404
Re: Serum HER-2 - Do You or Don't You?

I am no longer receiving this test, but sure wish I was.

When I switched health plans, my new oncologist at Kaiser said they don't use the Her2 Serum test. We are monitoring my disease using only the CA15-3, which is currently running at the high end of normal, to just above normal.

When we were using both the Her2 Serum and the CA15-3, the Her2 Serum was the first marker to rise when I had my recurrence in 2012, during my Herceptin vacation.

My tumor markers have always been a reliable indicator for me, and since I try to avoid scans as much as possible, they are my only warning system. That along with just trying to stay in tune with my body as much as possible.

Kim
__________________
Diag. Feb 1997 4.5cm IDC <10%ER+, PR-. 5 out of 36 nodes +. Mastectomy followed by 3 rounds Adriamycin/Cytoxin.


5/1997 Hi Dose Chemo w/ Stem cell rescue. Spent 4 weeks in isolation ward. Then 6 weeks radiation.

9/2001 widespread mets to liver. 8 mos Taxotere/Herceptin brought me almost to NED. Stop Taxotere & add Femara .

11/2002 liver resection to remove spot that turned out to be necrosis. Officially NED!

7/2003 Tumor markers rising add Xeloda Disastrous reaction, 8 days hospital, but tumor markers came back to normal!

June -Dec 2004 UW Vaccine Trial.

7/2005 MRI single 11mm brain met
8/2005 Gamma Knife.

Brain MRI @3 months NED!

2006-2011 brain/body still NED

8/04/11 Taking Herceptin break, will monitor with tumor markers.

6/20/12 Tumor markers begin to rise. CA15-3 is 31.3 and Her2 Serum is at 17.1 Decide to repeat in one month.

7/23/12 CA15-3 now 49.3
Her2 Serum 26.8

8/6/12 Back on Herceptin
CA15-3 now 76
Her2 Serum now 49

11/7/12 Add weekly Taxotere for 4 cycles

2/2013 Stopped Taxotere added Perjeta. MRI shows approx. 50% reduction liver mets. CA15-3 still elevated @ 55. Will continue on just Herceptin & Perjeta.

November 2014 Continuing on Herceptin, Perjeta, and
Femara indefinitely. Guess I'm NED again, but watching those tumor markers carefully!

Dec. 2015 PET scan reveals mass in perirectal area of abdomen.biopsy confirms. Still Her2+, but no longer ER+. Bye bye Femara

Jan 2016 Begin Kadcyla

March 2016 PET scan shows tumor now barely visible, still NED everywhere else.
2016/2017 continue Kadcyla

November 2017 brain MRI reveals small focus of T2 hyperintensity with possible 4mm enhancing nodule. Short term follow up MRI suggested. Stay tuned...
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