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Re: way to make herceptin much more effective IDd
Great reply thank you Lani!
My tries so far - I've done everolimus with herceptin and vinorelbine - best response - 7 months of stability
Tykerb and Xeloda - best response in reduction of disease but not maintained - progression after 5months (skin mets disappeared though - lung mets grew back)
TDM1 - no response really apart from slowing of progression
Herceptin, pertuzamab and carboplatin - significant progression (may have occurred awaiting pertuzamab as it was held up in customs - possible I was stable for a couple of months) currently changed carboplatin for Abraxane - have seem a small decline in tumor markers after first cycle - first decline in 12 months - scans next week.
My problem is I'm in Australia with limited access now to trials
I have spoken to one onc about afatinib - which I think is worth a go given my success with tykerb. Using everolimus again is an option too.
I've asked my onc to look into HSP90 options too.
I have a p53 mutation in the cancer also and I know I also highly express her3 but not EFGR or pi3k. But then not each tumor is the same.
I will look at the articles and info you suggest but I fear I will not be able to access anything here in Australia.
Thanks for taking the time to respond.
__________________
Amanda xx
40 year old Mum to three gorgeous kids - son 5 and daughters 8 and 11
Wife to my wonderfully supportive husband of 17 years!
22 February 2011 - Diagnosed Early Breast Cancer IDBC Stage2b (ER/PR -ve, Her2+ve +++) - 38 years old
(L) skin sparing mastectomy with tissue expander, axilla clearance (2/14 affected) clear margins.
Fec*3, Taxotere and herceptin*2 - stopped due to secondary diagnosis
June 24 2011 Stage IV - Skin met, axilla node, multiple lung lesions
Bolero3 trial - Navelbine, Hereptin weekly, daily Everolimus/Placebo
February 2012 - July 2012 Tykerb and Xeloda - skin mets resolved, Lungs initially dramatically reduced but growing again
August 2012 (turn 40!) tykerb and herceptin (denied compassionate use of TDM1) while holidaying in Italy!
September 2012 - January 2013 TDM1 as part of the Th3resa trial - lymph nodes resolved, lungs slowly progressing.
January 2013 - herceptin, carboplatin and Perjeta (compassionate access)
April 2013 - Some progression in lungs and lymph nodes - Abraxane, Herceptin and Perjeta
July 2013 - mixed response - dramatic reduction of most lung disease, progression of smaller lung nodules and cervical and hilar nodes - ? Add avastin.
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