synergism of herceptin+pertuzumab and their effect on bc stem cells IDd

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It was only approved as a first line of treatment, and many of us needing it have had many lines of treatment. Basically, the FDA is only approving drugs under the narrow parameters of the trial, and the trials are presented to get fastest approval, not for all patients in need. In this case, it was assumed that the combo would be most effective in a first line, and therefore the rest of us have been excluded.