Trying to deprive your breast cancer from estrogen may not be so easy after al

[KristinSchwick]

So glad that we have a reverse osmosis water purification system in our house to clean our water.

I wonder if they have tried to grow human cell lines in vitro by supplementing them with these estrogen derivatives. I also wonder if these or other hormones that we consume actually survive the digestion process intact and thereby enter our bloodstream. It seams unlikely to me that bovine estrogen would be both exempt from the toxic digestive enzymes AND significantly activate human estrogen receptors. Any thoughts?

[Jackie07]

[Some hope?]

J Hazard Mater. 2012 May 15. [Epub ahead of print]
De-conjugation behavior of conjugated estrogens in the raw sewage, activated sludge and river water.

Kumar V, Johnson AC, Nakada N, Yamashita N, Tanaka H.
Source

Research Center for Environmental Quality Management, Kyoto University, 1-2 Yumihama, Otsu, Shiga 520-0811, Japan.

Abstract

The fate and behavior of estrone-3-sulfate (E1-3S), estradiol-3-sulfate (E2-3S), estrone-3-glucuronide (E1-3G) and estradiol-3-glucuronide (E2-3G) were studied in raw sewage, activated sludge and river water using microcosms. The glucuronide conjugates had a half-life of 0.4h in raw sewage, yielding 40-60% of their free estrogens.

Field observations at three activated sludge processes suggested complete transformation of the glucuronide conjugates in the sewer. In river water glucuronide conjugates half-lives extended to over 2d yielding 60-100% of their free parent estrogens. Transformation of the sulfate conjugates in raw sewage and river water was slow with little formation of the parent estrogens. Sulfate conjugates could readily be detected in sewage influent in the field studies. In activated sludge the sulfate conjugates had half-lives of 0.2h with the transient formation of 10-55% of the free parent estrogens.

Field studies indicated transformation of sulfate conjugates across the sewage treatment, although a proportion escaped into the effluent. These results broadly support the view that glucuronide conjugates will be entirely transformed within the sewer largely to their parent estrogens.

The sulfate conjugates may persist in raw sewage and river water but are transformable in activated sludge and, in the case of E2-3S, reform a high proportion of the parent estrogen.
Copyright © 2012 Elsevier B.V. All rights reserved.