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Re: Guinea Pig - Metformin Trial
Woot! Woot! Woot! I am officially in the study. I drove to Mount Holly this morning on an empty stomach to have a blood draw. They took enough for a transfusion (well, okay, maybe not, but there sure were a lot of vials). I then received my giant bottle of horse pills, and I immediately popped the first one. Probably not the smartest thing I could've done, but I had a smoothie down in the car, and I was drinking it within five minutes.
Since then, I've had the glassy-eyed headache (classic hypoglycemia symptom for me), mild feeling of threatened nausea (that feeling you get right before you actually start feeling nauseated), a wildly churning stomach after I ate lunch and belly bloat when I woke up from my nap. All that seems promising, except every single symptom can be as easily explained by fasting followed by the two cups of coffee I drank on the ride home. Time will tell, although it's pretty well established that as far as drugs go, I either have nearly no side effects at all or else I have a paradoxical drug reaction. No in-between for me.
It turns out that I was their first enrollee. They do have others in the pipeline, but they're eager to enroll more. If anyone is interested, I'll be happy to give you the name and phone number of the person to talk to (she's a gem) at the Virtua Fox Chase Cancer Program and answer questions about the procedure to get in.
@Rich, the pills are indeed 850 mg (of something), so after the first 28 days, the dose is a total of 1700 mg.
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2/6/09 Core needle biopsy: negative; Mammos through 2010: no change
3/30/11 Pea-sized lump in left breast at site of prior biopsy; mammo negative, sonogram not so much
4/14/11 Core needle biopsy: negative for cancer
5/18/11 Excisional biopsy 1.2 cm tumor, LVI, positive margin; ER+60%,PR+20%,HER2/CEP17 5
6/15/11 BMX: Left DCIS & LH; Right ADH; SNB: 2/3 nodes: 1.4 cm and 1 mm; ALND L1&2: 0/10; Stage IIa, Grade 3
7/14/11 CT/Bone scans NED; MUGA 66%
7/19/11 Biweekly dd AC w/Neulasta; done 8/30/11
9/13/11 Transfusion (Hemoglobin 8.6); MUGA 64%
9/20/11 Start Taxol + Herceptin; Taxol done 12/6/2011; continue Herceptin until 9/4/2012
12/27/11 Radiation - 6 weeks; 2/27/2012 - DONE! Yayyyy!
2/29/12 Start Tamoxifen 20 mg/day; continue until 2/28/17
5/16/12 Start five-years Metformin trial
6/19/12 MUGA 61%
8/21/12 Brain MRI NED (head still hurts, brain still fogged)
9/4/12 Herceptin done!
9/6/12 Port out!
7/11/13 Aricept 5mg for cognitive impairment; increased to 10mg as of 8/23/13; back to 5mg 12/2013
5/2014 Add Namenda 7mg
9/2014 Stop Aricept and Namenda; Neuropsychological evaluation
10/24/14 Start cognitive rehabilitation therapy
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Hybrid Mode
