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09-25-2010, 03:20 AM
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#1
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Senior Member
Join Date: Mar 2006
Posts: 1,843
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Beta Glucans yeast based may assist monoclonal antibody therapies
HI All
I was a at a conference on fats which included a lecture on Beta-Glucans, which was highly thought provoking.
I found this link that sets out the core what was said.
http://www.biosolutions.info/2010/02...tem-video.html
Abstract
"Beta-glucans seem to make the immune system work better without becoming overactive. In addition to enhancing the activity of the immune system, beta-glucans also reportedly lower elevated levels of LDL cholesterol, aid in wound healing, help prevent infections, and have potential as an adjuvant in the treatment of cancer."
Yeast apparently contains the most effective beta glucans for activating the innate immune system. Apparently those in mushrooms are much less effective, and the impression given was that those in some cereals again have limited effects.
It was suggested that natural yeasts are found on foods, but our treatment of vegetables with bleach may destroy them, and hence our greater need for beta glucans.
I am trying to find out if standard brewers yeast contains the relevant beta glucans. There are some supplements products with a range of prices.
I will try and find and post links to some of the trials cited in the lecture in the next few days, including one suggesting the beta glucans increased the effect of monoclonal treatments.
As always consult your medical advisor about supplementation.
Last edited by R.B.; 09-25-2010 at 10:51 AM..
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09-25-2010, 04:13 AM
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#2
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Senior Member
Join Date: Feb 2009
Posts: 1,526
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Re: Beta Glucans yeast based may assist monoclonal antibody therapies
Thanks RB
Becky posted some information a while ago about possible good effects of beta glucan and herceptin in that it activates the pten pathway.
Look forward to any further info as to best sources as this seems to be a problem.
Ellie
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09-27-2010, 03:56 PM
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#3
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Senior Member
Join Date: Mar 2006
Posts: 1,843
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Re: Beta Glucans yeast based may assist monoclonal antibody therapies
Hi unfortunately the lecture notes provided do not give the links to the slides that were shown on the use of glucans in liver cancer, which were remarkable.
I will try and find them through the net, and by making enquiries of the organisers.
In the mean while, this is an interesting general paper on beta-glucans, which available in full for free on the web (-:
b-Glucans in promoting health:
Prevention against mutation and cancer
http://www.alpron.co.jp/bglucansinpromotinghealth.pdf
"The polysaccharides b-glucans occur as a principal component of the cellular walls. Some microorganisms, such as yeast and
mushrooms, and also cereals such as oats and barley, are of economic interest because they contain large amounts of b-glucans.
These substances stimulate the immune system, modulating humoral and cellular immunity, and thereby have beneficial effect in
fighting infections (bacterial, viral, fungal and parasitic). b-Glucans also exhibit hypocholesterolemic and anticoagulant properties.
Recently, they have been demonstrated to be anti-cytotoxic, antimutagenic and anti-tumorogenic, making them promising
candidate as pharmacological promoters of health."
Last edited by R.B.; 09-28-2010 at 02:46 AM..
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09-27-2010, 06:22 PM
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#4
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Senior Member
Join Date: Jan 2008
Location: "Love never fails."
Posts: 5,808
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Re: Beta Glucans yeast based may assist monoclonal antibody therapies
Another research paper echos the same effect:
Clin Cancer Res. 2010 Sep 20. [Epub ahead of print]
Orally Administered Particular {beta}-Glucan Modulates Tumor-capturing Dendritic Cells and Improves Anti-tumor T Cell Responses in Cancer.
Li B, Cai Y, Qi C, Hansen R, Ding C, Mitchell T, Yan J.
Medicine, University of Louisville.
Abstract
PURPOSE: The beneficial properties of β-glucans have been recognized for centuries. Their proposed mechanisms of action in cancer therapy occur via stimulation of macrophages and priming of innate neutrophil complement receptor 3 (CR3) for eliciting CR3-dependent cellular cytotoxicity of iC3b-opsonized tumor cells. The current study is to investigate whether β-glucan therapy has any impact on anti-tumor adaptive T cell responses.
EXPERIMENTAL DESIGN: We first examined the trafficking of orally administered particulate yeast-derived β-glucan and its interaction with dendritic cells (DCs) that captured tumor materials. Antigen-specific T cells were adoptively transferred into recipient mice to determine whether oral β-glucan therapy induces augmented T cell responses. Lewis lung carcinoma and RAM-S lymphoma models were used to test oral β-glucan therapeutic effect. Further mechanistic studies including tumor-infiltrating T cells and cytokine profiles within the tumor milieu were determined.
RESULTS: Orally administered particulate β-glucan trafficked into spleen and lymph nodes and activated DCs that captured dying tumor cells in vivo, leading to the expansion and activation of antigen-specific CD4 and CD8 T cells. In addition, IFN-γ production of tumor-infiltrating T cells and CTL responses were significantly enhanced upon β-glucan treatment, which ultimately resulted in significantly reduced tumor burden. Moreover, β-glucan-treated tumors had significantly more DC infiltration with the activated phenotype and significant levels of Th1-biased cytokines within the tumor microenvironment.
CONCLUSIONS: These data highlight the ability of yeast-derived β-glucan to bridge innate and adaptive anti-tumor immunity and suggest that it can be used as an adjuvant for tumor immunotherapy.
__________________
Jackie07
http://www.kevinmd.com/blog/2011/06/doctors-letter-patient-newly-diagnosed-cancer.html
http://www.asco.org/ASCOv2/MultiMedi...=114&trackID=2
NICU 4.4 LB
Erythema Nodosum 85
Life-long Central Neurocytoma 4x5x6.5 cm 23 hrs 62090 semi-coma 10 d PT OT ST 30 d
3 Infertility tmts 99 > 3 u. fibroids > Pills
CN 3 GKRS 52301
IDC 1.2 cm Her2 +++ ER 5% R. Lmptmy SLNB+1 71703 6 FEC 33 R Tamoxifen
Recc IIB 2.5 cm Bi-L Mast 61407 2/9 nds PET
6 TCH Cellulitis - Lymphedema - compression sleeve & glove
H w x 4 MUGA 51 D, J 49 M
Diastasis recti
Tamoxifen B. scan
Irrtbl bowel 1'09
Colonoscopy 313
BRCA1 V1247I
hptc hemangioma
Vertigo
GI - > yogurt
hysterectomy/oophorectomy 011410
Exemestane 25 mg tab 102912 ~ 101016 stopped due to r. hip/l.thigh pain after long walk
DEXA 1/13
1-2016 lesions in liver largest 9mm & 1.3 cm onco. says not cancer.
3-11 Appendectomy - visually O.K., a lot of puss. Final path result - not cancer.
Start Vitamin D3 and Calcium supplement (600mg x2)
10-10 Stopped Exemestane due to r. hip/l.thigh pain OKed by Onco 11-08-2016
7-23-2018 9 mm groundglass nodule within the right lower lobe with indolent behavior. Due to possible adenocarcinoma, Recommend annual surveilence.
7-10-2019 CT to check lung nodule.
1-10-2020 8mm stable nodule on R Lung, two 6mm new ones on L Lung, a possible lymph node involvement in inter fissule.
"I WANT TO BE AN OUTRAGEOUS OLD WOMAN WHO NEVER GETS CALLED AN OLD LADY. I WANT TO GET SHARP EDGED & EARTH COLORED, TILL I FADE AWAY FROM PURE JOY." Irene from Tampa
Advocacy is a passion .. not a pastime - Joe
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09-27-2010, 06:22 PM
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#5
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Senior Member
Join Date: May 2008
Location: Hershey, PA. Live The Sweet Life!
Posts: 2,005
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Re: Beta Glucans yeast based may assist monoclonal antibody therapies
Yea! More for the arsenal! thanks R.B. I will be watching for the updates.
__________________
Smile On!
Laurel
Dx'd w/multifocal DCIS/IDS 3/08
7mm invasive component
Partial mast. 5/08
Stage 1b, ER 80%, PR 90%, HER-2 6.9 on FISH
0/5 nodes
4 AC, 4 TH finished 9/08
Herceptin every 3 weeks. Finished 7/09
Tamoxifen 10/08. Switched to Femara 8/09
Bilat SPM w/reconstruction 10/08
Clinical Trial w/Clondronate 12/08
Stopped Clondronate--too hard on my gizzard!
Switched back to Tamoxifen due to tendon pain from Femara
15 Years NED
I think I just might hang around awhile....
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09-27-2010, 11:31 PM
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#6
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Senior Member
Join Date: Jan 2008
Location: "Love never fails."
Posts: 5,808
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Re: Beta Glucans yeast based may assist monoclonal antibody therapies
A statement in the Weblink cited by R.B. proves the [Shiitake] 'mushroom' power discussed previously by Elaine and others:
Beta-glucans, like lentinan (derived from the Shiitake mushroom) and Polysaccharide-K, have been used as an immunoadjuvant therapy for cancer since 1980, primarily in Japan. There is a large collection of research which demonstrates beta-glucans have anti-tumor and anti-cancer activity.
__________________
Jackie07
http://www.kevinmd.com/blog/2011/06/doctors-letter-patient-newly-diagnosed-cancer.html
http://www.asco.org/ASCOv2/MultiMedi...=114&trackID=2
NICU 4.4 LB
Erythema Nodosum 85
Life-long Central Neurocytoma 4x5x6.5 cm 23 hrs 62090 semi-coma 10 d PT OT ST 30 d
3 Infertility tmts 99 > 3 u. fibroids > Pills
CN 3 GKRS 52301
IDC 1.2 cm Her2 +++ ER 5% R. Lmptmy SLNB+1 71703 6 FEC 33 R Tamoxifen
Recc IIB 2.5 cm Bi-L Mast 61407 2/9 nds PET
6 TCH Cellulitis - Lymphedema - compression sleeve & glove
H w x 4 MUGA 51 D, J 49 M
Diastasis recti
Tamoxifen B. scan
Irrtbl bowel 1'09
Colonoscopy 313
BRCA1 V1247I
hptc hemangioma
Vertigo
GI - > yogurt
hysterectomy/oophorectomy 011410
Exemestane 25 mg tab 102912 ~ 101016 stopped due to r. hip/l.thigh pain after long walk
DEXA 1/13
1-2016 lesions in liver largest 9mm & 1.3 cm onco. says not cancer.
3-11 Appendectomy - visually O.K., a lot of puss. Final path result - not cancer.
Start Vitamin D3 and Calcium supplement (600mg x2)
10-10 Stopped Exemestane due to r. hip/l.thigh pain OKed by Onco 11-08-2016
7-23-2018 9 mm groundglass nodule within the right lower lobe with indolent behavior. Due to possible adenocarcinoma, Recommend annual surveilence.
7-10-2019 CT to check lung nodule.
1-10-2020 8mm stable nodule on R Lung, two 6mm new ones on L Lung, a possible lymph node involvement in inter fissule.
"I WANT TO BE AN OUTRAGEOUS OLD WOMAN WHO NEVER GETS CALLED AN OLD LADY. I WANT TO GET SHARP EDGED & EARTH COLORED, TILL I FADE AWAY FROM PURE JOY." Irene from Tampa
Advocacy is a passion .. not a pastime - Joe
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09-28-2010, 09:56 AM
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#7
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Senior Member
Join Date: May 2006
Posts: 3,142
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Re: Beta Glucans yeast based may assist monoclonal antibody therapies
I have been eating foods with beta-glucans everyday ever since my diagnosis almost 12 years ago. I think it is helping.
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