The researchers were comparing the cellular pathways of bc in humans, to those of the mouse models that are used to test human drugs. At page 21, they state:
"The MMTV-Neu strain, however, does not accurately recapitulate HER2-overexpressing cancers arising in women, since MMTV-Neu tumors do not show significant gene overlap with the HER2- positive subtype but are more similar to human ‘luminal’ tumors."
I don't know what the implications are for research on Her2+ bc treatments using MMTV-Neu bc strains in mice, but thought I would bring it up.
Hopeful
Hybrid Mode
