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08-22-2009, 04:51 AM
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#1
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Senior Member
Join Date: Sep 2005
Location: MN
Posts: 731
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taxol & vision changes
Last fall/winter I was on taxol/avastin & having vision problems. Things seemed blurry and I couldn't see distance with or without glasses as well as I used to. I was also having lots of sinus and other colds/viruses that I thought might be causing this. I went to the eye dr. twice & both times had a slightly different prescription in left eye - mostly in the astigmatism ranges. I have had cataract surgery in both eyes & artificial lens from that so technically the vision shouldn't change. Anyway my infections cleared up and my vision improved. And I went from taxol / avastin to gemzar.
Now I'm back on taxol with carbo. Again I'm experiencing vision issues - same thing - can't see distance as sharply as before -- or even detail on the TV set 8-10 feet away. But sometimes it seems better than others. I don't have any sinus or virus issues going on.
Since the cataract surgery I've been able to not have to wear glasses - but do like them for driving especially at night. I need to get new glasses soon but I don't know what to do about the correction... my current glasses don't seem to help as much now as they did before I restarted the taxol. Do I get my eyes tested again now & go with what's current prescription now? If/when I get off taxol then take the chance that the new glasses won't help? As you know glasses aren't cheap!
How have others adapted to vision changes due to chemo?
__________________
Pam
6/01 IBC er+ her2+stage IIIb; mastecomy
7/01 AC, taxol; radiation
2/02 tamoxifen
9/02 stage IV bone mets femara
1/03 taxotere/herceptin/aredia
6/03 herceptin, aredia & faslodex
1/04 navelbine, herceptin, aredia
2/05 herceptin/aredia
7/05 xeloda/herceptin/aredia
3/07 xeloda/tykerb/aredia
5/08 taxol/avastin/aredia
2/09 gemzar/herceptin/zometa
7/09 Taxol/Carbo/Herceptin, zometa
10/09 navelbine/herceptin & zometa
2/10 herceptin & tykerb & zometa
4/10 add xeloda &aromasin
10/10 dx with dermatomyiositis triggered by cancer
11/10 restart herceptin, tykerb, zometa
12/10 surgery-place rod in R femur to stabilize bone
1/11 radiation to R femur - 20 tx
2/11 2nd surgery - rod in Left femur
2/11 tx eribulen -- suspended dx brain mets
3/11 brain mets wbr 20 tx
4/11 halaven; discontine 8/11 not working
8/11 radiation to left femur 20 tx'
8-9/11 rad to lower spine
9/11 abraxane/herceptin/zometa
9/12 xeloda/herceptin/zometa
12/12 ablation of liver
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08-22-2009, 06:48 AM
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#2
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Senior Member
Join Date: Feb 2009
Posts: 1,526
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Re: taxol & vision changes
Hi Pam
Since having taxotere my vision has definitely got much worse. It is now often blurry and things I could easily see before I started are now much harder. At first I thought it was due to watery eyes from the herceptin but now think its the taxotere. It is annoying as I just bought a new pair of reading glasses just before treatment and now they are no good
Ellie
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08-22-2009, 07:13 AM
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#3
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Senior Member
Join Date: Jan 2008
Location: Evergreen, Colorado
Posts: 454
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Re: taxol & vision changes
Pam,
I too was on taxotere and felt that my eye sight was getting worse. At the completion of 6 rounds of chemo I went and had my eyes checked and there didn't appear to be any measureable changes. Hmmmm...I would have SWORN there was.
It did not continue to get worse but I can't say that I feel like things improved either.
Very annoying.
__________________
2007
Oct - Diagnosed - Stage IV 5 c.m. IDC - Left Side er/pr- Her2+++ Node + 2/14 - Single Liver Met Double Mastectomy Nov - Begin T+H 2008
Feb-Complete 6 cycles- T&H- NED
March - Continue - Herceptin Only
April - Rads for 6 weeks
2009
Continue Herceptin - Continue NED
April - Recurrance- 3 cm. Liver Met
May - Cryosurgery
June - November - Abraxane + Herceptin
Aug - PET/CT - CTC = 0 Back to NED
2010
January - Continue NED
July - Recurrance - 3 cm Liver Met CTC=1
August - Cryosurgery #2
August - November Navelbine
November - Back to NED - End Navelbine
2011
Feb - Recur - 4 cm Liver Met - Same Left Lobe
March Surgery it is -Couldn't get a clean margin
July - Confirmed continued liver involvement
August - Begin Herceptin + Tykerb
October - Mixed results from H+T
Add Abraxane + H + T - Nov - April
2012
January PET Scan - It's working!!
April - Back to NED
July - Recurrance
August - Begin TDM-1 Trial (Taxol + TDM-1)
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08-22-2009, 12:45 PM
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#4
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Senior Member
Join Date: Dec 2008
Location: Southern Indiana
Posts: 455
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Re: taxol & vision changes
Lori, I can say almost the very same story. My eye checkup did not show measureful change... but I could have thought there was.
__________________
Alice
04/08 age 50 III IBC Her2+++ ER/PR-8cm 14/14 Double M, Body and Brain CT/PET clear, ? on spine,Muga 53
06/08, 4 A/C, Neulasta
08/08, Herceptin/tax 12 every week
10/08, CT/PET clear, ? on pelvis, hips, MUGA 43, started Enalaprial for heart, Herceptin every 3 weeks
11/08 33Rads; 12/08 MUGA 48
2/09 MRI spine and bone scan, old mets to spine, Chest x-ray, blood work, IV NED,regular CPAP use,Zometa x6, first -flue like symptoms 2 days;Herceptin x3; stage 2 lymphoedema..sleeve and glove
4/09 Brain MRI - CLEAR; MUGA 54
7/09 chest ultrasound,
10/09 PET, brain and spin MRI NED Herceptin only. MUGA 59!!!
1/11 Hip replacement 7/11 Hip 2 replacement
4/12 4 years!! Herceptin
6/12 start reconstruction finish in 12/12
2/14 Herception - 6 years!!!
1 Corinthians 10:13 "No temptation has seized you except what is common to man. And God is faithful; he will not let you be tempted beyond what you can bear. But when you are tempted, he will also provide a way out so that you
can stand up under it."
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08-22-2009, 03:39 PM
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#5
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Senior Member
Join Date: May 2006
Posts: 3,142
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Re: taxol & vision changes
Hi all,
Taxanes ( Taxotere, Taxol, Abraxane etc.) can cause vision problems like sensitivity to light, conjunctivitis, cornea damage, dryness, and loss of vision according to one of the oncology nurses who worked in my doc's office. I overheard her telling another patient to wear sunglasses and a hat outside to avoid those eye problems. I asked her about it after that. She told me the same information. I looked it up and found the same thing. The information should be listed in the possible side effect section on the websites for those medicines.
www.taxotere.com, www.taxol.com, www.abraxane.com
Otherwise you should be able to call the 1-800 number for the drug companies that make those drugs and talk to a pharmacist. Most drug companies that make cancer medicines have patient help lines where patients can talk to pharmacists and ask questions about side effects.
By the way, I saw a ENT doc recently to check my ears.
My ears are just fine. However, he said that platin types of chemo (carboplatin, cisplatin etc. )can cause hearing loss, so anyone taking those drugs should have a hearing test once in awhile. Good tip !!
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08-22-2009, 04:43 PM
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#6
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Senior Member
Join Date: Nov 2004
Location: Misty woods of WA State
Posts: 4,128
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Re: taxol & vision changes
Hi Pam -
The taxanes tended to bother my eyesight as well.
I made do with what I had and then got new ones a couple months after finishing the treatment.
Do you by chance have some older frames that could get new lenses - just to tide you over? My insurance pays for lenses once a year.
__________________
"When I hear music, I fear no danger. I am invulnerable. I see no foe. I am related to the earliest times, and to the latest." H.D. Thoreau
Live in the moment.
MY STORY SO FAR ~~~~
Found suspicious lump 9/2000
Lumpectomy, then node dissection and port placement
Stage IIB, 8 pos nodes of 18, Grade 3, ER & PR -
Adriamycin 12 weekly, taxotere 4 rounds
36 rads - very little burning
3 mos after rads liver full of tumors, Stage IV Jan 2002, one spot on sternum
Weekly Taxol, Navelbine, Herceptin for 27 rounds to NED!
2003 & 2004 no active disease - 3 weekly Herceptin + Zometa
Jan 2005 two mets to brain - Gamma Knife on Jan 18
All clear until treated cerebellum spot showing activity on Jan 2006 brain MRI & brain PET
Brain surgery on Feb 9, 2006 - no cancer, 100% radiation necrosis - tumor was still dying
Continue as NED while on Herceptin & quarterly Zometa
Fall-2006 - off Zometa - watching one small brain spot (scar?)
2007 - spot/scar in brain stable - finished anticoagulation therapy for clot along my port-a-catheter - 3 angioplasties to unblock vena cava
2008 - Brain and body still NED! Port removed and scans in Dec.
Dec 2008 - stop Herceptin - Vaccine Trial at U of W begun in Oct. of 2011
STILL NED everywhere in Feb 2014 - on wing & prayer
7/14 - Started twice yearly Zometa for my bones
Jan. 2015 checkup still shows NED
2015 Neuropathy in feet - otherwise all OK - still NED.
Same news for 2016 and all of 2017.
Nov of 2017 - had small skin cancer removed from my face. Will have Zometa end of Jan. 2018.
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08-23-2009, 10:27 AM
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#7
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Senior Member
Join Date: Feb 2009
Location: Canada
Posts: 128
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Re: taxol & vision changes
I just finished Taxol and have noticed a steady decline in my vision throughout chemo to the point I am not sure I want to drive and haven't been. Distance and close vision have been affected, eyes are often teary, itchy, and blurry. I can't even see faces across the room. I have found that it ALL affects my vision; all of the chemotherapy, Herceptin and have also noticed another decline in vision with the Zometa. I read about Zometa and conjunctivitis is a common side effect. I have decided to just feel my way around the house, tape broom handles to my arms to allow the book to be far enough away, gotten out the magnifying glass, and will just endure until I am far out of treatment before getting new glasses. Gosh, cancer treatment just keeps giving and giving, doesn't it.
__________________
12/17/08 biopsy after two 6 mos mammo recalls
12/30/08 diagnosed high grade IDC & DCIS ER/PR +, Her2 (+++) post menopausal/age 57
1/15/09 double mastectomy/skin sparing; no evidence of vascular/lymphatic invasion, 8neg/8 nodes (tumor 8.0mm)
2/16/09 given portacath/removed 4/30/10
2/18/09 "surprise" 2.0mm tumor/positive borders~completed 28 rads 10/09.
2/23/09 until 4/19/10~treatments every 3wks (4 Cytoxan + Adriamycin, 4 Taxol + Herceptin, 13 Herceptin alone)
8/09 osteoporosis diagnosis/Zometa 3 yrs of 1x/6 months
Chemo side effects; Deafness, kidney function loss
11/09 began Aromatase Inhibitor (Femara)/Feb2014, stopped Femara early/after 3 mos began Tamoxifen for 8 mos to complete 5 years
11/10 Reconstruction, directly to silicone implants
12/11 nipples by skin graft/Right breast size reduced
I have heard there are troubles of more than one kind
Some come from ahead and some come from behind.
But I've bought a big bat. I'm all ready you see.
Now my troubles are going to have trouble with me!
Dr. Seuss
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08-24-2009, 05:31 AM
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#8
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Senior Member
Join Date: Aug 2003
Location: Morris, IL
Posts: 3,507
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Re: taxol & vision changes
Pam
My vision worsened the 2 years on Taxol....kept getting stronger glasses, and also used Restasis regularly for the dry eyes....it could be the Taxol or it could be the steroids...both can play havoc on the eyes. Hope your eyes improve....you may need to see the eye Dr more often....I kept blaming it on age...I think it was the Taxol!!!!!
__________________
"Be kinder than necessary, for everyone you meet is fighting some kind of battle."
Hugs & Blessings
Sheila
Diagnosed at age 49.99999 2/21/2002 via Mammography (Calcifications)
Core Biopsy 2/22/02
L. Mastectomy 2/25/2002
Stage 1, 0.7cm IDC, Node Neg from 19 nodes Her2+++ ER PR Neg
6/2003 Reconstruction W/ Tissue Expander, Silicone Implant
9/2003 Stage IV with Mets to Supraclavicular nodes
9/2003 Began Herceptin every 3 weeks
3/2006 Xeloda 2500mg/Herceptin for recurrence to neck nodes
3/2007 Added back the Xeloda with Herceptin for continued mets to nodes
5/2007 Taken Off Xeloda, no longer working
6/14/07 Taxol/Herceptin/Avastin
3/26 - 5/28/08 Taxol Holiday Whopeeeeeeeee
5/29 2008 Back on Taxol w Herceptin q 2 weeks
4/2009 Progression on Taxol & Paralyzed L Vocal Cord from Nodes Pressing on Nerve
5/2009 Begin Rx with Navelbine/Herceptin
11/09 Progression on Navelbine
Fought for and started Tykerb/Herceptin...nodes are melting!!!!!
2/2010 Back to Avastin/Herceptin
5/2010 Switched to Metronomic Chemo with Herceptin...Cytoxan and Methotrexate
Pericardial Window Surgery to Drain Pericardial Effusion
7/2010 Back to walking a mile a day...YEAH!!!!
9/2010 Nodes are back with a vengence in neck
Qualified for TDM-1 EAP
10/6/10 Begin my miracle drug, TDM-1
Mixed response, shrinking internal nodes, progression skin mets after 3 treatments
12/6/10 Started Halaven (Eribulen) /Herceptin excellent results in 2 treatments
2/2011 I CELEBRATE my 9 YEAR MARK!!!!!!!!!!!!!
7/5/11 begin Gemzar /Herceptin for node progression
2/8/2012 Gemzar stopped, Continue Herceptin
2/20/2012 Begin Tomo Radiation to Neck Nodes
2/21/2012 I CELEBRATE 10 YEARS
5/12/2012 BeganTaxotere/ Herceptin is my next miracle for new node progression
6/28/12 Stopped Taxotere due to pregression, Started Perjeta/Herceptin
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08-24-2009, 07:06 AM
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#9
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Senior Member
Join Date: May 2006
Posts: 3,142
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Re: taxol & vision changes
I was just reading that Decadron (a steriod)which is given before many kinds of chemo including Taxotere and Taxol to prevent some of the more dangerous side effects can contribute to vision problems too. People taking these two drugs together may be getting a double dose of vision problems.
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09-02-2009, 09:36 AM
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#10
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Member
Join Date: Jul 2009
Location: Lewes DE
Posts: 19
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Re: taxol & vision changes
I've been on TCH until I got a really bad rash -- so bad my oncologist has changed my regimen to AC for two treatments followed by 2 of Taxol. I wrote about this in a separate thread on rashes.
When I got the rash after my second treatment, it felt as if it was affecting my eyes. Ever since (three weeks and a day), my vision seems blurry and my eyes feel dry or watery, etc.
I'm hoping it was the taxotere that I will not get anymore.
I am going to see my eye doctor tomorrow.
Sandy
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