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the article
ABSTRACT: Dumbbell-like Au-Fe3O4 Nanoparticles for Target-Specific Platin Delivery
[Journal of the American Chemical Society; Subscribe]
Dumbbell-like Au-Fe3O4 nanoparticles (NPs) were made and coupled with Herceptin and a platin complex. The platin-Au-Fe3O4-Herceptin NPs act as a target-specific nanocarriers for delivery of platin into Her2-positive breast cancer cells (Sk-Br3) with strong therapeutic effects. The conjugate has a half-maximal inhibitory concentration (IC50) toward Sk-Br3 cells of 1.76 μg of Pt/mL, which is lower than that needed for cisplatin (3.5 μg/mL). The work demonstrates that the dumbbell-like Au-Fe3O4 NPs are promising nanocarriers for highly sensitive diagnostic and therapeutic applications.
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