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Old 02-10-2009, 05:53 AM   #1
eric
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Join Date: Sep 2005
Posts: 589
Julie,

How long ago were you on it the first time? Studies have shown that you can go back to the well if it's been more than, I believe 2 years (might be 1 year...my memory stinks these days). Caryn went to NED on Gemzar/Herceptin and I'm planning on pushing for that when the time is right. I pray that this revisit brings back the magic for you. Please keep us informed.

Eric
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Old 02-10-2009, 06:59 AM   #2
julierene
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Join Date: Dec 2005
Location: Illinois
Posts: 327
First month scans on new treatment went well

For the first time in 4 months, the scans were finally better. The liver looked significantly better after only one month of this "old" treatment. The only thing they changed was they switched Taxol to Abraxane. There isn't too much difference in that, but it seems to be helping. The bone mets were stable, the liver looked better, and the CA 27/29 was a few points lower. It was only decreased from 132 to like 129... but I hope month 2 will be better. I was just surprised that the liver finally looked better. I had been off Herceptin for a while, so I wasn't willing to give up on it. I was more willing to think that the Navelbine wasn't working. I did feel like I had exhausted the efficacy of Tykerb - at least for a few years.

It was Dec 05 when I first did the Carboplatin/Herceptin/Taxol. It made everything disappear within 3 months. I don't know if that will happen this time, but I am sure hoping so! If not, we will be switching to Avastin + something. I have great hopes for Avastin. Anyway, it gets scary getting down to the point where the oncologist is telling you to look for trials and the drugs are limited.

Julie
__________________
Jan04: Bilateral Mastectomy at age 28
Initial DX: Left Breast: IDC 2cm, Grade 3, HER2+3, 0 Nodes +, ER/PR-. Right Breast: Extensive DCIS ER-/PR+; Stage 1-2a
Feb04-Apr04: 4 AC, dose dense
Aug 04: 4 Taxotere
Dec 05: Bone and Liver METS; Stage 4. Carboplatin/Taxol/Herceptin. DX with Li-Fraumeni Syndrome
Apr 06: NED, maintenance Herceptin
Apr 07: CA1503=14; masses in liver; Xeloda/Tykerb
Nov 07: NED, Tykerb maintenance
Sept 08: Liver mets again, on Tykerb/Xeloda again, CA=19 and 27
Nov 08: Progression, Tykerb/Gemzar, CA=25
Dec 08: Progression, Herceptin/Navelbine, CA=40, 57, and 130
Jan 09: Progression in bone, recession in liver, Herceptin/Carbo/Abraxane CA=135
June 09: CA27/29=24, chemo break
Sept 09: Progression, CA=24, waiting on clinical trial (4 weeks no treatment)
Nov 09: now have brain mets, trial "on hold", getting 14 WBR treatments starting 11/2/09
Dec 09: possible start on p53 trial
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