This is technical and relates to pancreatic cancer and not BC (although it mentions it) and posted for specialists who keep an eye on this thread if any.
But the pathways under discussion are so basic there is undoubtedly some communality, as in the impact of COX blockers like aspirin in BC.
Linoleic acid is the plant based Omega 6.
A way of reducing Omega 6 COX and LOX activity is not to eat excess Omega 6 in the first place, and Omega 3 DHA has been shown to be a natural COX blocker.
The article gives an idea as to how widespread the effects of the products of Omega 6 are.
Lipoxygenase and cyclooxygenase metabolism: new insights in treatment and chemoprevention of pancreatic cancer
Xian-Zhong Ding,1 Rene Hennig,1 and Thomas E Adriancorresponding author1
1Department of Surgery and Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Tarry 4-711, Chicago, IL 60611, U.S.A
http://www.pubmedcentral.nih.gov/art...i?artid=149414
"
COX and LOX metabolism of linoleic and arachidonic acids leads to the formation of a variety of metabolically active products with different roles in carcinogenesis. Our understanding of these roles is steadily increasing. This new information is providing a theoretical basis for development of new cancer chemoprevention approaches targeted to COX and LOX activity."
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