Lani, I need advice too!

[fullofbeans]

Ha sorry..hope I have not offended..

[Lani]

A case with complete resolution of multiple liver mets with the combination of capecitabine and herceptin :

Breast Cancer. 2007;14(3):297-301.
Complete remission of recurrent breast cancer with multiple liver metastases after oral capecitabine and injected trastuzumab.

Morohashi S, Odagiri H, Morohashi H, Kimura Y, Sasaki M.
Department of Surgery, Hirosaki University School of Medicine, Hirosaki, Japan. hm2002@cc.hirosaki-u.ac.jp
A 32-year-old woman underwent modified radical mastectomy for right breast cancer (invasive ductal carcinoma, f, INF beta, v0, ly1, pT2, pN1, M0, Stage II B ER (+/-), PR (-), Her2 (3+)) in June 2003, and received postoperative systemic adjunctive chemotherapy using epirubicin combined with cyclophosphamide, followed by paclitaxel. In August 2004, after a disease-free interval of 14 months, liver metastasis appeared, and therefore from September 2004, combination chemotherapy with oral capecitabine (2,400 mg/day) and injected trastuzumab (120 mg/week) was started. After 3 cycles, all the metastases responded and this marked response has been maintained for 16 months. This therapy is currently being continued (19 cycles), and no serious side effects have been encountered. Capesitabine and trastuzumab combination therapy is effective for recurrent breast cancer showing overexpression of HER2 and resistance to taxane, and can be considered as a first-line therapy for this purpose. It is anticipated that many cases treated with this regimen will be reported and discussed in the near future.
PMID: 17690508 [PubMed - indexed for MEDLINE]

[HavahJ]

No problem.

[HavahJ]

Hi Lani, I've just started the second chemo, only been on two weeks.navelbine/hercep/xeloda/tykerb. What do you think this swift rise in tumor marker means? I can't believe what really hasn't been above 100 in 20 years. I think I should just stay on the chemo. I just had aCT a couple of weeks ago and A PET not that long ago. What could such a high marker mean. The CA27, 29 has always been completely accurate for me. Thank you HavahJ@aol.com (Jan)

[Lani]

I am not an oncologist or oncologic nurse or any other professional with experience with chemo, have never had chemo myself and have no idea how quickly markers change

That sort of thing is rarely covered in articles...it seems to be part of the wealth of experience oncologists have from treating patients, which is why you should rely on them.

Have you found one you have faith in? Having faith in someone is not to say you should not to read the literature and not ask others on this board for input and then discuss items with him/her.

Others here can answer your specific questions better. I can just search the published literature.

Hopefully others with similar stories will chime in.

[Lani]

http://her2support.org/vbulletin/forumdisplay.php?f=29