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Old 02-22-2008, 12:30 PM   #1
Lani
Senior Member
 
Join Date: Mar 2006
Posts: 4,778
for those who have gallstones, or are worried about them

I seem to remember that several members have had their gallbladders removed since being diagnosed with breast cancer.

This may seem very speculative, but I have previously posted on monoclonal antibodies being associated with low levels of magnesium

Here is a paper on how Magnesium may protect against gallstones

Perhaps they are all connected?

http://www.medscape.com/viewarticle/570527

to access medscape

please go to www.medscape.com and fill in the following

(I found it under the important links section of this website):

Username: Her2support
Password: Member
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Old 02-22-2008, 12:42 PM   #2
Lani
Senior Member
 
Join Date: Mar 2006
Posts: 4,778
pubmed check of monoclonal antibodies, hypomagnesemia

--it has been described for EGFR(her1) monoclonal antibodies mainly (cetuximab), but it is unclear whether tykerb which blocks her1 and her2
may have a similar effect , let alone herceptin




Disorders of renal magnesium handling explain renal magnesium transport.
J Nephrol. 2007 Sep-Oct;20(5):507-10. Review.
PMID: 17918133 [PubMed - indexed for MEDLINE]
3:
Related Articles, LinksJin JP, Chong SM, Hossain MM.

Related Articles, LinksGroenestege WM, Thébault S, van der Wijst J, van den Berg D, Janssen R, Tejpar S, van den Heuvel LP, van Cutsem E, Hoenderop JG, Knoers NV, Bindels RJ.

Impaired basolateral sorting of pro-EGF causes isolated recessive renal hypomagnesemia.
J Clin Invest. 2007 Aug;117(8):2260-7.
PMID: 17671655 [PubMed - indexed for MEDLINE]
5:
Related Articles, LinksMuallem S, Moe OW.

When EGF is offside, magnesium is wasted.
J Clin Invest. 2007 Aug;117(8):2086-9.
PMID: 17671646 [PubMed - indexed for MEDLINE]
6:
Related Articles, LinksTejpar S, Piessevaux H, Claes K, Piront P, Hoenderop JG, Verslype C, Van Cutsem E.

Magnesium wasting associated with epidermal-growth-factor receptor-targeting antibodies in colorectal cancer: a prospective study.
Lancet Oncol. 2007 May;8(5):387-94.
PMID: 17466895 [PubMed - indexed for MEDLINE]
7:
Related Articles, LinksFakih M.

Anti-EGFR monoclonal antibody-induced hypomagnesaemia.
Lancet Oncol. 2007 May;8(5):366-7. No abstract available.
PMID: 17466890 [PubMed - indexed for MEDLINE]
.



Related Articles, LinksPerrin C, Fabre C, Raoul JL, Boucher E.

Behavioral disorders secondary to profound hypomagnesemia in a patient given cetuximab for metastatic colorectal cancer hypomagnesemia due to cetuximab treatment.
Acta Oncol. 2006;45(8):1135-6. No abstract available.
PMID: 17118852 [PubMed - indexed for MEDLINE]
12:
Related Articles, LinksFakih MG, Wilding G, Lombardo J.

Cetuximab-induced hypomagnesemia in patients with colorectal cancer.
Clin Colorectal Cancer. 2006 Jul;6(2):152-6.
PMID: 16945172 [PubMed - indexed for MEDLINE]



15:
Related Articles, LinksAltundag K, Altundag O, Baptista MZ, Turen S, Atik MA.

Re: Cetuximab therapy and symptomatic hypomagnesemia.
J Natl Cancer Inst. 2005 Dec 7;97(23):1791-2. No abstract available.
PMID: 16333039 [PubMed - indexed for MEDLINE]
16:
Related Articles, LinksSilverstein DM, Aviles DH, LeBlanc PM, Jung FF, Vehaskari VM.


Related Articles, LinksSchrag D, Chung KY, Flombaum C, Saltz L.

Cetuximab therapy and symptomatic hypomagnesemia.
J Natl Cancer Inst. 2005 Aug 17;97(16):1221-4. Review.
PMID: 16106027 [PubMed - indexed for MEDLINE]
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